专利检索 ap:("Antonin de Fougerolles" OR "Andrew Sprague" OR "Jens Harborth" OR "Maria Gabriela Belvisi" OR "Mark Andrew Birrell" OR "Elizabeth Ouise Hardaker" OR "Matthew Copeland Catley") AND inv:"Antonin de Fougerolles" 第 1 页

1.

发明申请
Compositions And Methods For Inhibiting Expression Of IKK-B Gene 有权
标题翻译：抑制IKK-B基因表达的组成和方法

公开(公告)号：US20110112178A1

公开(公告)日：2011-05-12

申请号：US12982261

申请日：2010-12-30

申请人： Antonin de Fougerolles , Andrew Sprague , Jens Harborth , Maria Gabriela Belvisi , Mark Andrew Birrell , Elizabeth Ouise Hardaker , Matthew Copeland Catley

发明人： Antonin de Fougerolles , Andrew Sprague , Jens Harborth , Maria Gabriela Belvisi , Mark Andrew Birrell , Elizabeth Ouise Hardaker , Matthew Copeland Catley

IPC分类号： A61K31/713 , C07H21/02 , C12N15/63 , C12N5/00 , A61P29/00

CPC分类号： C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12Y207/1101 , C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.

摘要翻译： 本发明涉及用于抑制IKK-B基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸，长度通常为19-25个核苷酸的核苷酸序列的反义链，以及其基本上与IKK-B基因的至少一部分互补。本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由IKK-B基因的表达或活化引起的疾病的方法; 以及抑制细胞中IKK-B基因表达的方法。

2.

发明授权
Compositions and methods for inhibiting expression of IKK-B gene 有权
标题翻译：抑制IKK-B基因表达的组合物和方法

公开(公告)号：US09000143B2

公开(公告)日：2015-04-07

申请号：US12982261

申请日：2010-12-30

申请人： Antonin de Fougerolles , Andrew Sprague , Jens Harborth , Maria Gabriela Belvisi , Mark Andrew Birrell , Elizabeth Louise Hardaker , Matthew Copeland Catley

发明人： Antonin de Fougerolles , Andrew Sprague , Jens Harborth , Maria Gabriela Belvisi , Mark Andrew Birrell , Elizabeth Louise Hardaker , Matthew Copeland Catley

IPC分类号： C07H21/04 , C12N15/113

CPC分类号： C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12Y207/1101 , C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.

摘要翻译： 本发明涉及用于抑制IKK-B基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸，长度通常为19-25个核苷酸的核苷酸序列的反义链，以及其基本上与IKK-B基因的至少一部分互补。本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由IKK-B基因的表达或活化引起的疾病的方法; 以及抑制细胞中IKK-B基因表达的方法。

3.

发明申请
SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES 审中-公开
标题翻译：信号传感器多核苷酸修饰细胞基因

公开(公告)号：US20140200261A1

公开(公告)日：2014-07-17

申请号：US14041011

申请日：2013-09-30

申请人： Stephen G. Hoge , Tirtha Chakraborty , Joshua P. Frederick , Matthias John , Antonin de Fougerolles

发明人： Stephen G. Hoge , Tirtha Chakraborty , Joshua P. Frederick , Matthias John , Antonin de Fougerolles

IPC分类号： A61K48/00 , C12N15/85

CPC分类号： C07K14/47 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K48/0058 , C12N15/113 , C12N15/85 , C12N2310/141

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

摘要翻译： 本发明涉及用于制备，制造和治疗性使用信号传感器多核苷酸，初级转录物和mmRNA分子的组合物和方法。

4.

发明申请
MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 有权
标题翻译：修饰的多核苷酸编码SEPTIN-4

公开(公告)号：US20140141067A1

公开(公告)日：2014-05-22

申请号：US14107079

申请日：2013-12-16

申请人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss

发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss

IPC分类号： C07K14/47

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.

摘要翻译： 本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。

5.

发明申请
MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 有权
标题翻译：修饰的多核苷酸编码病毒诱导因子1

公开(公告)号：US20140107189A1

公开(公告)日：2014-04-17

申请号：US14106988

申请日：2013-12-16

申请人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss

发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss

IPC分类号： C07K14/535 , C07K14/505

CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.

摘要翻译： 本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。

6.

发明申请
Lipid Formulated Compositions and Methods for Inhibiting Expression of Serum Amyloid A Gene 有权
标题翻译：脂质制剂组合物和抑制血清淀粉样蛋白A基因表达的方法

公开(公告)号：US20110263684A1

公开(公告)日：2011-10-27

申请号：US13120601

申请日：2009-09-25

申请人： Antonin de Fougerolles , Tatiana Novobrantseva , Gregory Hinkle

发明人： Antonin de Fougerolles , Tatiana Novobrantseva , Gregory Hinkle

IPC分类号： A61K31/713 , C12N5/071 , C12N15/63 , A61P29/00 , A61P1/00 , A61P11/00 , A61P35/00 , A61P35/02 , A61P19/02 , A61P31/08 , A61P43/00 , A61P17/10 , A61P1/16 , A61P31/00 , A61P13/12 , C07H21/02

CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3515

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.

摘要翻译： 本发明涉及靶向血清淀粉样蛋白A（SAA）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制SAA表达的方法。

7.

发明申请
PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS 审中-公开
标题翻译：磷酸二酯和非核苷酸磷酸酯作为iRNA代理的递送剂

公开(公告)号：US20110218334A1

公开(公告)日：2011-09-08

申请号：US13003355

申请日：2009-07-10

申请人： Martin Maier , Muthiah Manoharan , Kallanthottathil G. Rajeev , Kevin Fitzgerald , Antonin de Fougerolles , Tatiane Novobrantseva , Anna Borodovsky , Maria Frank-Kamenetsky

发明人： Martin Maier , Muthiah Manoharan , Kallanthottathil G. Rajeev , Kevin Fitzgerald , Antonin de Fougerolles , Tatiane Novobrantseva , Anna Borodovsky , Maria Frank-Kamenetsky

IPC分类号： C07H21/02

CPC分类号： C12N15/1137 , C12N15/111 , C12N2310/14 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/3341 , C12N2310/3513 , C12N2310/3515 , C12N2310/3519 , C12N2320/32

摘要： The invention relates to use of single-stranded phosphorothioate oligonucleotides or non-nucleosidic phosphrothiaote as vehicles or carriers to modulate the biodistribution of iRNA agents.

摘要翻译： 本发明涉及单链硫代磷酸酯寡核苷酸或非核苷酸磷酸硫磷酸酯作为载体或载体来调节iRNA试剂的生物分布的用途。

8.

发明授权
Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same 失效
标题翻译：编码人B淋巴细胞活化抗原B7家族成员的核酸及其使用方法

公开(公告)号：US06429303B1

公开(公告)日：2002-08-06

申请号：US09651200

申请日：2000-08-30

申请人： Cynthia Green , Victor Kotelianski , Antonin de Fougerolles , John Carulli , Catherine Hession

发明人： Cynthia Green , Victor Kotelianski , Antonin de Fougerolles , John Carulli , Catherine Hession

IPC分类号： C07H2104

CPC分类号： C07K14/70532 , A61K38/00 , Y10S435/81

摘要： An isolated BLAA polynucleotide and the membrane-associated or secreted polypeptide encoded by the BLAA polynucleotide are disclosed. Also disclosed are the antibodies that immunospecifically bind to a BLAA polypeptide or any derivative, variant, mutant or fragment of the BLAA polypeptide, polynucleotide or antibody. Also disclosed are nucleic acid vectors and host cells containing the nucleic acid sequence of the invention.

摘要翻译： 公开了分离的BLAA多核苷酸和由BLAA多核苷酸编码的膜相关或分泌的多肽。还公开了免疫特异性结合BLAA多肽或BLAA多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。还公开了含有本发明的核酸序列的核酸载体和宿主细胞。