摘要:
Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要:
The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.
摘要:
Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要:
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要:
The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.
摘要:
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要:
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要:
A beveled-end steel railroad. The use of small-acute-angle oblique-gap connection design and vertical gap reservation design can solve both the problem of impact between wheels and rails and the problem of thermal stress between steel rails. The design containing both beveled ends and flat ends that are complementary to each other can further greatly reduce railroad construction and reformation costs. The beveled-end steel railroad has a simple structure, is secure, reliable, and durable, can provide a fast, stable, and non-noisy driving effect, can implement highly-efficient and energy-saving operation, is easy to construct and reform, can be easily repaired and maintained, has a significant advantage in costs, and can implement both good performance and good profitability.
摘要:
An interface display method and system for a home gateway applicable to various display types are described. The interface display method for a home gateway applicable to various display types includes receiving a page request sent from a Hypertext Transport Protocol (HTTP) browser and extracting display type information and an original page according to the page request, and forming a page adaptive to the current display type according to the original page and the display type information. By determining the display type information corresponding to an output screen according to a page request sent by an HTTP browser and converting the original page into a standard active script page adaptive to the current display type according to the display type information, the method and system provided herein guarantee the uniformity of interfaces and can convert interface display more conveniently and rapidly.
摘要:
The present invention discloses a method, device and system for configuring codebooks. The method comprises a transmitting end selecting a code word restricted sub-set and informing a receiving end of the code word restricted sub-set, the code word restricted sub-set containing part or all of code words in a first codebook and/or a second codebook; and the receiving end selecting an optimal pre-coded code word from the code word restricted sub-set and informing the transmitting end of an index of the optimal pre-coded code word. By the present invention, code word restriction is implemented in the case of dual codebooks in the LTE-A system such that the calculation complexity is reduced when the receiving end selects the code word, occurrences of the case where the receiving end selects the code word wrongly are decreased, and the signaling structure in the LTE system can be inherited very well.