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公开(公告)号：US20230128094A1
公开(公告)日：2023-04-27
申请号：US17971511
申请日：2022-10-21
发明人： Brian Hayes Burrows , Sekar Krishnasamy , Ayyanagouda Raravi , Monika Mudalkar , Govindraj Desai , Hemantha Kumar Raju , Basavaraj Pattanshetty , David Masayuki Ishikawa , Visweswaren Sivaramakrishnan , Shrikant Swaminathan , Mario Cambron , Robert Navasca , Miaojun Wang , Jonathan Frankel
摘要： A reactor for coating particles includes a rotatable reactor assembly includes a reactor drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube. The drum includes a cylindrical tube, and an inlet-side endplate secured to cover an inlet-side opening of the cylindrical tube and/or an outlet-side endplate secured to cover an outlet-side opening of the cylindrical tube. A stationary gas inlet line is coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line is coupled to the outlet tube by a rotary outlet seal, and a motor rotates the rotatable reactor assembly. The inlet tube is releasably mechanically secured to the inlet-side endplate and the outlet tube is releasably mechanically secured to the outlet-side endplate.
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公开(公告)号：US20230127489A1
公开(公告)日：2023-04-27
申请号：US17971504
申请日：2022-10-21
发明人： Brian Hayes Burrows , Sekar Krishnasamy , Ayyanagouda Raravi , Monika Mudalkar , Govindraj Desai , Hemantha Kumar Raju , Basavaraj Pattanshetty , David Masayuki Ishikawa , Visweswaren Sivaramakrishnan , Shrikant Swaminathan , Mario Cambron , Robert Navasca , Miaojun Wang , Jonathan Frankel
摘要： A reactor for coating particles includes a rotatable reactor assembly including a drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube, a stationary gas inlet line coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line coupled to the outlet tube by a rotary outlet seal, and a motor to rotate the rotatable reactor assembly.
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公开(公告)号：US20230364023A1
公开(公告)日：2023-11-16
申请号：US18199614
申请日：2023-05-19
发明人： Miaojun Wang , Jonathan Frankel , Pravin K. Narwankar , Suneel Kumar Rastogi , Shivkumar Chiruvolu , Fei Wang , Balaji Ganapathy , Shrikant Swaminathan
IPC分类号： A61K9/50
CPC分类号： A61K9/501 , A61K9/5089
摘要： Methods for providing an inorganic oxide coating to high aspect ratio particles containing an active pharmaceutical ingredient are described as are compositions containing such coated particles.
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公开(公告)号：US20230132290A1
公开(公告)日：2023-04-27
申请号：US17971516
申请日：2022-10-21
发明人： Brian Hayes Burrows , Sekar Krishnasamy , Ayyanagouda Raravi , Monika Mudalkar , Govindraj Desai , Hemantha Kumar Raju , Basavaraj Pattanshetty , David Masayuki Ishikawa , Visweswaren Sivaramakrishnan , Shrikant Swaminathan , Mario Cambron , Robert Navasca , Miaojun Wang , Jonathan Frankel
IPC分类号： C23C16/458 , C23C16/44 , C23C16/455
摘要： A deposition system includes an isolator or fume hood and a reactor for coating particles, the reactor including a rotatable reactor assembly positioned within the isolator or fume hood and including a reactor drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube. The reactor drum is configured to be detached from the inlet tube and the outlet tube by an operator while the reactor drum remains within the isolator or fume hood.
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5.发明授权公开(公告)号：US12077856B2
公开(公告)日：2024-09-03
申请号：US18314707
申请日：2023-05-09
发明人： Jonathan Frankel , Colin C. Neikirk , Pravin K. Narwankar , Quoc Truong , Govindraj Desai , Sekar Krishnasamy , Shrikant Swaminathan
IPC分类号： C23C16/44 , B01F27/051 , B01F27/07 , B01F27/072 , B01F27/112 , B01F27/70 , B01J19/00 , B01J19/18 , C23C16/455
CPC分类号： C23C16/4417 , B01F27/051 , B01F27/0726 , B01F27/074 , B01F27/112 , B01F27/70 , B01J19/0066 , B01J19/18 , C23C16/45555
摘要： A reactor for coating particles includes a stationary vacuum chamber that has a lower portion that forms a half-cylinder and an upper portion and that holds a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, and a gas injection assembly that includes a vaporizer to convert a first liquid to a first reactant or precursor gas, a manifold to receive the first reactant or precursor gas from the vaporizer, and a plurality of channels leading from the manifold to a plurality of apertures located in the lower portion of the chamber.
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6.发明公开公开(公告)号：US20230279543A1
公开(公告)日：2023-09-07
申请号：US18314707
申请日：2023-05-09
发明人： Jonathan Frankel , Colin C. Neikirk , Pravin K. Narwankar , Quoc Truong , Govindraj Desai , Sekar Krishnasamy , Shrikant Swaminathan
IPC分类号： C23C16/44 , C23C16/455 , B01J19/00 , B01J19/18 , B01F27/051 , B01F27/70 , B01F27/07 , B01F27/112 , B01F27/072
CPC分类号： C23C16/4417 , B01F27/051 , B01F27/0726 , B01F27/074 , B01F27/112 , B01F27/70 , B01J19/0066 , B01J19/18 , C23C16/45555
摘要： A reactor for coating particles includes a stationary vacuum chamber that has a lower portion that forms a half-cylinder and an upper portion and that holds a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, and a gas injection assembly that includes a vaporizer to convert a first liquid to a first reactant or precursor gas, a manifold to receive the first reactant or precursor gas from the vaporizer, and a plurality of channels leading from the manifold to a plurality of apertures located in the lower portion of the chamber.
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7.发明授权公开(公告)号：US11674223B2
公开(公告)日：2023-06-13
申请号：US16855871
申请日：2020-04-22
发明人： Jonathan Frankel , Colin C. Neikirk , Pravin K. Narwankar , Quoc Truong , Govindraj Desai , Sekar Krishnasamy , Shrikant Swaminathan
IPC分类号： C23C16/44 , C23C16/455 , B01J19/00 , B01J19/18 , B01F27/051 , B01F27/70 , B01F27/07 , B01F27/112 , B01F27/072
CPC分类号： C23C16/4417 , B01F27/051 , B01F27/074 , B01F27/0726 , B01F27/112 , B01F27/70 , B01J19/0066 , B01J19/18 , C23C16/45555
摘要： A reactor for coating particles includes a stationary vacuum chamber having a lower portion that forms a half-cylinder and an upper portion to hold a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, a motor to rotate a drive shaft of the paddle assembly, a chemical delivery system to deliver a first fluid, and a first gas injection assembly to receive the first fluid from the chemical delivery system and having apertures configured to inject a first reactant or precursor gas into the lower portion of the chamber and such that the first reactant or precursor gas flows substantially tangent to a curved inner surface of the half-cylinder.
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