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公开(公告)号：US11560804B2
公开(公告)日：2023-01-24
申请号：US17832568
申请日：2022-06-03
发明人： Yuriy Melnik , Sukti Chatterjee , Kaushal Gangakhedkar , Jonathan Frankel , Lance A. Scudder , Pravin K. Narwankar , David Alexander Britz , Thomas Knisley , Mark Saly , David Thompson
IPC分类号： F01D5/28 , C23C16/455 , C23C16/34 , C23C16/40 , C23C16/30 , C23C16/56 , F01D9/02 , F01D25/12 , F01D25/28 , F23R3/28 , C07F11/00 , F01D25/14
摘要： Methods for forming protective coatings on aerospace components are provided. In one or more embodiments, the method includes exposing an aerospace component to a first precursor and a first reactant to form a first deposited layer on a surface of the aerospace component by a first deposition process (e.g., CVD or ALD), and exposing the aerospace component to a second precursor and a second reactant to form a second deposited layer on the first deposited layer by a second deposition process. The first deposited layer and the second deposited layer have different compositions from each other. The method also includes repeating the first deposition process and the second deposition process to form a nanolaminate film stack having from 2 pairs to about 1,000 pairs of the first deposited layer and the second deposited layer consecutively deposited on each other.
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公开(公告)号：US20220205091A1
公开(公告)日：2022-06-30
申请号：US17697845
申请日：2022-03-17
IPC分类号： C23C16/44 , C23C16/455 , B01J19/00 , B01J19/18 , B01F27/051 , B01F27/70 , B01F27/07 , B01F27/112 , B01F27/072
摘要： A method of coating particles includes dispensing particles into a vacuum chamber to form a particle bed in at least a lower portion of the chamber that forms a half-cylinder, evacuating the chamber through a vacuum port in an upper portion of the chamber, rotating a paddle assembly such that a plurality of paddles orbit a drive shaft to stir the particles in the particle bed, injecting a reactant or precursor gas through a plurality of channels into the lower portion of the chamber as the paddle assembly rotates to coat the particles, and injecting the reactant or precursor gas or a purge gas through the plurality of channels at a sufficiently high velocity such that the reactant or precursor a purge gas de-agglomerates particles in the particle bed.
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公开(公告)号：US20220186372A1
公开(公告)日：2022-06-16
申请号：US17590614
申请日：2022-02-01
IPC分类号： C23C16/455 , A61K9/16 , C23C16/44
摘要： A reactor for coating particles includes a vacuum chamber configured to hold particles to be coated, a vacuum port to exhaust gas from the vacuum chamber via the outlet of the vacuum chamber, a chemical delivery system configured to flow a process gas into the particles via a gas inlet on the vacuum chamber, one or more vibrational actuators located on a first mounting surface of the vacuum chamber, and a controller configured to cause the one or more vibrational actuators to generate a vibrational motion in the vacuum chamber sufficient to induce a vibrational motion in the particles held within the vacuum chamber.
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公开(公告)号：US20220105048A1
公开(公告)日：2022-04-07
申请号：US17492363
申请日：2021-10-01
IPC分类号： A61K9/50
摘要： A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more silicon oxide materials is provided. The method entails alternating exposing the particles to gaseous or vaporous SiCl4 and gaseous or vaporous H2O at a reduced temperature and in the absence of a catalyst.
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公开(公告)号：US20220064794A1
公开(公告)日：2022-03-03
申请号：US17522869
申请日：2021-11-09
发明人： Colin C. Neikirk , Pravin K. Narwankar , Kaushal Gangakhedkar , Visweswaren Sivaramakrishnan , Jonathan Frankel , David Masayuki Ishikawa , Quoc Truong , Joseph Yudovsky
IPC分类号： C23C16/455 , C23C16/44 , C23C16/442
摘要： A reactor for coating particles includes one or more motors, a rotary vacuum chamber configured to hold particles to be coated, wherein the rotary vacuum chamber is coupled to the motors, a controller configured to cause the motors to rotate the rotary vacuum chamber about an axial axis of the rotary vacuum chamber such that the particles undergo tumbling agitation, a vacuum port to exhaust gas from the rotary vacuum chamber, a paddle assembly including a rotatable drive shaft extending through the rotary vacuum chamber and coupled to the motors and at least one paddle extending radially from the drive shaft, such that rotation of the drive shaft by the motors orbits the paddle about the drive shaft in a second direction, and a chemical delivery system including a gas outlet on the paddle configured inject process gas into the particles.
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公开(公告)号：US20230128094A1
公开(公告)日：2023-04-27
申请号：US17971511
申请日：2022-10-21
发明人： Brian Hayes Burrows , Sekar Krishnasamy , Ayyanagouda Raravi , Monika Mudalkar , Govindraj Desai , Hemantha Kumar Raju , Basavaraj Pattanshetty , David Masayuki Ishikawa , Visweswaren Sivaramakrishnan , Shrikant Swaminathan , Mario Cambron , Robert Navasca , Miaojun Wang , Jonathan Frankel
摘要： A reactor for coating particles includes a rotatable reactor assembly includes a reactor drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube. The drum includes a cylindrical tube, and an inlet-side endplate secured to cover an inlet-side opening of the cylindrical tube and/or an outlet-side endplate secured to cover an outlet-side opening of the cylindrical tube. A stationary gas inlet line is coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line is coupled to the outlet tube by a rotary outlet seal, and a motor rotates the rotatable reactor assembly. The inlet tube is releasably mechanically secured to the inlet-side endplate and the outlet tube is releasably mechanically secured to the outlet-side endplate.
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公开(公告)号：US20230127489A1
公开(公告)日：2023-04-27
申请号：US17971504
申请日：2022-10-21
发明人： Brian Hayes Burrows , Sekar Krishnasamy , Ayyanagouda Raravi , Monika Mudalkar , Govindraj Desai , Hemantha Kumar Raju , Basavaraj Pattanshetty , David Masayuki Ishikawa , Visweswaren Sivaramakrishnan , Shrikant Swaminathan , Mario Cambron , Robert Navasca , Miaojun Wang , Jonathan Frankel
摘要： A reactor for coating particles includes a rotatable reactor assembly including a drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube, a stationary gas inlet line coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line coupled to the outlet tube by a rotary outlet seal, and a motor to rotate the rotatable reactor assembly.
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公开(公告)号：US20210378971A1
公开(公告)日：2021-12-09
申请号：US17341213
申请日：2021-06-07
发明人： Fei Wang , Miaojun Wang , Balaji Ganapathy , Jonathan Frankel , Shivkumar Chiruvolu , Pravin K. Narwankar
IPC分类号： A61K9/50 , A61K31/397 , A61K31/517 , A61K31/4422
摘要： A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.
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公开(公告)号：US20200340108A1
公开(公告)日：2020-10-29
申请号：US16855887
申请日：2020-04-22
IPC分类号： C23C16/44 , C23C16/455
摘要： A method of coating particles includes dispensing particles into a vacuum chamber to form a particle bed in at least a lower portion of the chamber that forms a half-cylinder, evacuating the chamber through a vacuum port in an upper portion of the chamber, rotating a paddle assembly such that a plurality of paddles orbit a drive shaft to stir the particles in the particle bed, injecting a reactant or precursor gas through a plurality of channels into the lower portion of the chamber as the paddle assembly rotates to coat the particles, and injecting the reactant or precursor gas or a purge gas through the plurality of channels at a sufficiently high velocity such that the reactant or precursor a purge gas de-agglomerates particles in the particle bed.
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10.发明申请公开(公告)号：US20200338521A1
公开(公告)日：2020-10-29
申请号：US16855871
申请日：2020-04-22
发明人： Jonathan Frankel , Colin C. Neikirk , Pravin K. Narwankar , Quoc Truong , Govindraj Desai , Sekar Krishnasamy
摘要： A reactor for coating particles includes a stationary vacuum chamber having a lower portion that forms a half-cylinder and an upper portion to hold a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, a motor to rotate a drive shaft of the paddle assembly, a chemical delivery system to deliver a first fluid, and a first gas injection assembly to receive the first fluid from the chemical delivery system and having apertures configured to inject a first reactant or precursor gas into the lower portion of the chamber and such that the first reactant or precursor gas flows substantially tangent to a curved inner surface of the half-cylinder.
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