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公开(公告)号：US20110034542A1
公开(公告)日：2011-02-10
申请号：US12742045
申请日：2008-11-09
申请人： Arie Dagan , Shimon Slavin , Shimon Gatt , Jeremy Zahavi
发明人： Arie Dagan , Shimon Slavin , Shimon Gatt , Jeremy Zahavi
IPC分类号： A61K31/7088 , C07C215/10 , A61K31/133 , A61K31/513 , A61K31/337 , A61K31/4375 , A61P35/00 , A61P37/02 , A61P25/28 , A61P3/00
CPC分类号： C07C215/12 , A61K31/133 , A61K31/4745 , A61K31/513 , C07C215/10 , Y02A50/409 , Y02A50/411
摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
摘要翻译： 本发明提供了新的表示为式（II）化合物的神经酰胺类似物。 这些新型类似物表现出显着的抗癌作用，因此作为治疗细胞增殖性疾病，神经变性疾病，代谢相关病症，感染性疾病和免疫相关疾病的药物组合物提供。 本发明还提供组合的组合物和试剂盒，其将式（II）的新型神经酰胺类似物与另外的治疗剂组合。
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公开(公告)号：US08962891B2
公开(公告)日：2015-02-24
申请号：US12742045
申请日：2008-11-09
申请人： Arie Dagan , Shimon Slavin , Shimon Gatt , Jeremy Zahavi
发明人： Arie Dagan , Shimon Slavin , Shimon Gatt , Jeremy Zahavi
IPC分类号： C07C215/10 , A61K31/13
CPC分类号： C07C215/12 , A61K31/133 , A61K31/4745 , A61K31/513 , C07C215/10 , Y02A50/409 , Y02A50/411
摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
摘要翻译： 本发明提供了新的表示为式（II）化合物的神经酰胺类似物。 这些新型类似物表现出显着的抗癌作用，因此作为治疗细胞增殖性疾病，神经变性疾病，代谢相关病症，感染性疾病和免疫相关疾病的药物组合物提供。 本发明还提供组合的组合物和试剂盒，其将式（II）的新型神经酰胺类似物与另外的治疗剂组合。
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公开(公告)号：US20100311841A1
公开(公告)日：2010-12-09
申请号：US12742036
申请日：2008-11-06
申请人： Arie Dagan , Shimon Gatt , Shimon Slavin
发明人： Arie Dagan , Shimon Gatt , Shimon Slavin
IPC分类号： A61K31/135 , C07C213/00
CPC分类号： C07C323/32 , C07C381/12
摘要： Therapeutic compounds based on synthetic sphingolipid analogs are provided, particularly alkylthiophenyl substituted ceramide analogs, suitable for treating degenerative, infectious, and other diseases.
摘要翻译： 提供了基于合成鞘脂类似物的治疗化合物，特别是烷基硫代苯基取代的神经酰胺类似物，其适于治疗退行性，感染性和其它疾病。
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4.发明授权Detection of binding of charged species using PH- or potential-sensitive probes 失效使用PH或潜敏感探针检测带电物种的结合公开(公告)号：US07056653B2
公开(公告)日：2006-06-06
申请号：US09780757
申请日：2001-02-08
CPC分类号： G01N33/92 , C12Q1/6804 , G01N33/5432 , G01N33/582 , G01N2405/04 , C12Q2563/179 , C12Q2527/119
摘要： The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
摘要翻译： 通过在表面上稳定地并入表面，确定表面上的局部环境具有在部分结合时被改变的pH或表面电位的表面上的部分（例如生物分子）与表面结合的程度， 含有pH或潜在敏感的荧光团。
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5.发明授权
公开(公告)号：US5492924A
公开(公告)日：1996-02-20
申请号：US126361
申请日：1993-09-24
申请人： Shimon Gatt , Arie Dagan , Rene Santus , Jean-Claude Maziere , J. Donald Chapman , Edward L. Engelhardt
发明人： Shimon Gatt , Arie Dagan , Rene Santus , Jean-Claude Maziere , J. Donald Chapman , Edward L. Engelhardt
IPC分类号： A61K31/40 , A61K41/00 , A61K49/00 , A61K51/04 , C07D487/22
CPC分类号： A61K51/0485 , A61K31/40 , A61K41/0071 , A61K49/0036 , C07D487/22 , A61K2123/00
摘要： Phorbine derivatives having high potency and light absorptivity in the 650 to 780 nanometer range are useful in cancer diagnosis and therapy, especially photodynamic therapy.
摘要翻译： 在650至780纳米范围内具有高效能和光吸收性的菲啡宾衍生物可用于癌症诊断和治疗，特别是光动力疗法。
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6.发明授权
公开(公告)号：US5401413A
公开(公告)日：1995-03-28
申请号：US653319
申请日：1991-02-11
CPC分类号： A62D3/02 , B09C1/10 , A62D2101/20 , A62D2101/22 , F02B2075/027 , H05K3/26 , Y10S210/922 , Y10S210/925
摘要： The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.
摘要翻译： 本发明提供了一种用于增强可生物降解的有机废物的生物降解的组合物，其包括有机废物消费微生物和脂质体的组合，其中所述脂质体为细菌生长提供必需营养物，同时增加废物的极性和润湿性，从而增加其可用性以增强 细菌相互作用及其使用方法。
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7.发明授权Method for cleaning industrial and domestic articles and surfaces contaminated with organic or lipophilic wastes 失效清洁受有机或亲脂性废物污染的工业和家庭用品和表面的方法
公开(公告)号：US5376183A
公开(公告)日：1994-12-27
申请号：US13846
申请日：1993-02-05
CPC分类号： A62D3/02 , B09C1/10 , A62D2101/20 , A62D2101/22 , F02B2075/027 , H05K3/26 , Y10S210/922 , Y10S210/925
摘要： The present invention provides a method for cleaning industrial and domestic surfaces and articles, as herein defined, which are contaminated with organic or lipophilic wastes, comprising applying liposomes thereto, which liposomes modify the physical properties of said wastes to increase the polarity and wettability thereof.
摘要翻译： 本发明提供了一种用于清洁工业和家庭表面和如本文所定义的物品的方法，其被有机或亲脂性废物污染，包括向其中施加脂质体，该脂质体改变所述废物的物理性质以增加其极性和润湿性。
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公开(公告)号：US5593508A
公开(公告)日：1997-01-14
申请号：US364587
申请日：1994-12-27
申请人： Shimon Gatt , Yechezkel Barenholz , Herve Bercovier , Zvi Eldar
发明人： Shimon Gatt , Yechezkel Barenholz , Herve Bercovier , Zvi Eldar
CPC分类号： B09C1/10 , F02B2075/027 , H05K3/26 , Y10T442/2279 , Y10T442/2484 , Y10T442/2525
摘要： The invention provides a moist, absorbent material for cleaning articles and surfaces, wherein the material is moistened with an aqueous solution containing liposomes having vesicles of a diameter of up to about 100 nm.
摘要翻译： 本发明提供了一种用于清洁制品和表面的潮湿吸收材料，其中用含有直径大约100nm的囊泡的脂质体的水溶液润湿材料。
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9.发明授权Composition for enhancing the biodegradation of biodegradable organic wastes 失效用于增强可生物降解的有机废物的生物降解的组合物
公开(公告)号：US5510112A
公开(公告)日：1996-04-23
申请号：US310522
申请日：1994-09-22
IPC分类号： A62D3/00 , A62D3/02 , B09C1/10 , F02B75/02 , H05K3/26 , A61K9/127 , A61K9/133 , C02F1/40 , C02F3/00
CPC分类号： A62D3/02 , B09C1/10 , A62D2101/20 , A62D2101/22 , F02B2075/027 , H05K3/26 , Y10S210/922 , Y10S210/925
摘要： The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.
摘要翻译： 本发明提供了一种用于增强可生物降解的有机废物的生物降解的组合物，其包括有机废物消费微生物和脂质体的组合，其中所述脂质体为细菌生长提供必需营养物，同时增加废物的极性和润湿性，从而增加其可用性以增强 细菌相互作用及其使用方法。
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公开(公告)号：US5244574A
公开(公告)日：1993-09-14
申请号：US943147
申请日：1992-09-10
申请人： Shimon Gatt , Yechezkel Barenholz
发明人： Shimon Gatt , Yechezkel Barenholz
CPC分类号： C02F3/344 , C02F1/681 , Y10S210/922 , Y10S210/925
摘要： The invention provides a method for treating oil spills on water comprising applying liposomes to a body of water to form a monomolecular layer of phospholipid molecules on the water surface which phosopholipid molecules break up a continuous layer of oil into oil droplets each of which is surrounded by a monomolecular layer of phospholipids.
摘要翻译： 本发明提供了一种处理水上溢油的方法，包括将脂质体施加到水体上，以在水面上形成磷脂分子的单分子层，磷脂分子将连续的油层分解成油滴，每个油滴被 磷脂的单分子层。
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