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公开(公告)号：US4420689A
公开(公告)日：1983-12-13
申请号：US333629
申请日：1981-12-22
CPC分类号： H01J47/065
摘要： An inner and outer cylindrical cathode are concentrically positioned about a vertical center axis. Vertical anode electrodes extend parallel to the center axis and are symmetrically arranged around the inter-cylinder space between the cathodes. The ends of the anode wires are supported by a pair of insulator rings mounted near the top and bottom of the cathode cylinders. A collection voltage applied to each anode wire for establishing an inward radial E field to the inner cathode cylinder and an outward radial E field to the outer cathode cylinder. The anode-cathode assembly is mounted within a housing containing a conversion gas. A radioactive sample is inserted into the inner cathode which functions as a tubular, deep well radiation window between the sample environment and the conversion gas environment. A portion of the gamma radiations passing through the inter-cylinder region interact with the conversion gas to produce free electrons which are accelerated by the E fields and collected on the anode wires. The extremely small diameter of the anode wires intensifies the electric fields proximate each wire causing avalanche multiplication of the free electrons resulting in a detectable charge pulse.
摘要翻译： 内圆柱形阴极和外圆柱形阴极围绕垂直中心轴线同心定位。 垂直阳极电极平行于中心轴线延伸，并且围绕阴极之间的气缸间间隔对称地布置。 阳极线的端部由安装在阴极筒的顶部和底部附近的一对绝缘体环支撑。 施加到每个阳极线的收集电压，以建立到内阴极筒的向内径向E场和向外部阴极筒的向外径向E场。 阳极 - 阴极组件安装在包含转化气体的壳体内。 将放射性样品插入内阴极，其作用在样品环境和转化气体环境之间的管状深井辐射窗口。 通过气缸间区域的伽马辐射的一部分与转化气体相互作用以产生由E场加速并收集在阳极线上的自由电子。 阳极线的非常小的直径增强了每个线附近的电场，导致自由电子的雪崩倍增，产生可检测的充电脉冲。
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2.发明授权Method of operating an optical sensor adapted for selective analyte-sensing contact with a plurality of samples 有权操作适于与多个样品进行选择性分析物感测接触的光学传感器的方法公开(公告)号：US06387709B1
公开(公告)日：2002-05-14
申请号：US09941807
申请日：2001-08-29
IPC分类号： G01N2101
CPC分类号： G01N21/8483 , Y10T436/10
摘要： A multiple single use optical sensor includes a series of continuous sensor stripes deposited on a substrate web. At least one sample chamber is adapted to extend transversely across a discrete portion of the series of sensor stripes to facilitate analysis of a sample disposed therein. The sample chamber may be moved, or additional sample chambers provided to enable subsequent measurements of additional samples at unused discrete portions of the sensor stripes. The continuous nature of the sensor stripes provides consistency along the lengths thereof to enable calibration data obtained from one discrete portion of the sensor stripes to be utilized for testing an unknown sample an other discrete portion of the sensor stripes. This advantageously eliminates the need for any particular discrete portion of the sensor stripes to be contacted by more than one sample, for improved sensor performance.
摘要翻译： 多用途光学传感器包括沉积在基片网上的一系列连续传感器条纹。 至少一个样品室适于横向延伸穿过该系列传感器条的离散部分，以便于分析其中设置的样品。 可以移动样品室，或者提供附加的样品室，以便能够在传感器条纹的未使用的分立部分的后续测量附加样品。 传感器条带的连续性质提供沿其长度的一致性，使得从传感器条的一个离散部分获得的校准数据可用于测试未知样品传感器条纹的其他离散部分。 这有利地消除了对传感器条的任何特定离散部分与多于一个样品的接触的需要，以提高传感器性能。
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3.发明授权Apparatus for and method of assuring the quality of the results obtained from a blood gas analyzer 失效用于确保从血气分析仪获得的结果的质量的装置和方法
公开(公告)号：US4375743A
公开(公告)日：1983-03-08
申请号：US184760
申请日：1980-09-08
申请人： Kevin J. Sullivan
发明人： Kevin J. Sullivan
CPC分类号： B65D83/62 , B01L3/50 , Y02W30/807
摘要： Disclosed is an apparatus for a method for assuring the quality of the results obtained from a blood gas analyzer. The apparatus comprises a device for storing blood gas quality control reagent comprising a first variable volume, gas impermeable container for receiving the reagent. The reagent is stored exclusively in the liquid phase therein. A valved exit passageway emanates from the container which container is situated in a second container surrounding the first, a space being present therebetween and a compressed gas situated in the space. Upon opening the valve, the compressed gas decreases the volume of the first container and reagent is expelled through the exit passageway. The present device is uneffected by changes in ambient temperature since the reagent is stored exclusively in the liquid phase. The device is reusable since a portion of the reagent may be expelled without contamination of the remaining contents. Further, a method is disclosed for storing blood gas quality control reagent such that it is stored exclusively in a liquid phase.
摘要翻译： 公开了一种用于确保从血气分析仪获得的结果的质量的方法的装置。 该装置包括用于存储血气质量控制试剂的装置，其包括用于接收试剂的第一可变体积的不透气容器。 试剂专门储存在液相中。 一个带阀的出口通道从容器中排出，该容器位于围绕第一容器的第二容器中，存在于其间的空间和位于该空间中的压缩气体。 在打开阀时，压缩气体减小第一容器的体积，试剂通过出口通道排出。 本装置不受环境温度变化的影响，因为试剂仅储存在液相中。 该装置是可重复使用的，因为一部分试剂可被排出而不污染剩余的内容物。 此外，公开了一种用于存储血液气体质量控制试剂的方法，使其仅以液相存储。
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公开(公告)号：US4013038A
公开(公告)日：1977-03-22
申请号：US597323
申请日：1975-07-21
摘要： Apparatus for controlling the temperature of an open liquid body when actual measurement of that temperature is not possible. A thermal analog of the liquid body, which is exposed to the same heating or cooling source as the liquid body, is incorporated into a sensor which provides controlling feedback to the heating or cooling source. The sensor, which is disposed in the atmosphere which surrounds or flows by the liquid body, includes a dry element and a wet wick, body of which are in thermal contact with a temperature sensing element. The dry element senses the temperature of the atmosphere and the wet wick has a cooling effect on the sensing element that is related to the rate of evaporation of liquid from the body. This sensor is advantageously employed in a system for regulating the temperature of a reagent film on a microscope slide.
摘要翻译： 用于在不能实际测量该温度时控制开放液体的温度的装置。 暴露于与液体相同的加热或冷却源的液体的热模拟物被并入到向加热或冷却源提供控制反馈的传感器中。 设置在由液体包围或流动的气氛中的传感器包括干燥元件和湿芯，其与热敏元件热接触。 干燥元件感测大气的温度，湿芯对感测元件具有与来自身体的液体的蒸发速率相关的冷却效果。 该传感器有利地用于用于调节显微镜载片上的试剂膜的温度的系统。
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5.发明授权Multi-analyte reference solutions with stable pO2 in zero headspace containers 有权在零顶空容器中具有稳定pO2的多分析物参考溶液公开(公告)号：US06632675B1
公开(公告)日：2003-10-14
申请号：US09641033
申请日：2000-08-16
IPC分类号： G01N3100
CPC分类号： B65D75/5877 , B01L3/505 , B01L2200/025 , B01L2200/026 , B01L2300/10 , B32B15/08 , B65D75/58 , B65D75/5861 , G01N27/4163 , G01N33/0006 , G01N33/4925 , G01N33/96 , G01N2001/2893 , G01N2496/70 , G01N2496/80 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/104998 , Y10T436/105831 , Y10T436/106664 , Y10T436/25
摘要： Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature and are packaged in laminated foil containers having low or no oxygen reactivity. Access devices are also disclosed.
摘要翻译： 公开了在零顶空包装中具有稳定的氧分压（pO
2 ）的多分析物参比溶液及其制备方法。 当在室温下储存时，溶液具有长的搁置和使用寿命，并且被包装在具有低或不具有氧反应性的层压箔容器中。 还公开了接入设备。 -
公开(公告)号：US06488891B2
公开(公告)日：2002-12-03
申请号：US09941499
申请日：2001-08-29
IPC分类号： G01N2101
CPC分类号： G01N21/8483 , Y10T436/10
摘要： A multiple single use optical sensor includes a series of continuous sensor stripes deposited on a substrate web. At least one sample chamber is adapted to extend transversely across a discrete portion of the series of sensor stripes to facilitate analysis of a sample disposed therein. The sample chamber may be moved, or additional sample chambers provided to enable subsequent measurements of additional samples at unused discrete portions of the sensor stripes. The continuous nature of the sensor stripes provides consistency along the lengths thereof to enable calibration data obtained from one discrete portion of the sensor stripes to be utilized for testing an unknown sample an other discrete portion of the sensor stripes. This advantageously eliminates the need for any particular discrete portion of the sensor stripes to be contacted by more than one sample, for improved sensor performance.
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公开(公告)号：US06254831B1
公开(公告)日：2001-07-03
申请号：US09009917
申请日：1998-01-21
申请人： Steven M. Barnard , Thomas C. Collins , Susan L. Cudmore , Richard W. Mason , Christiane Munkholm , Rudolf E. Slovacek , Kevin J. Sullivan
发明人： Steven M. Barnard , Thomas C. Collins , Susan L. Cudmore , Richard W. Mason , Christiane Munkholm , Rudolf E. Slovacek , Kevin J. Sullivan
IPC分类号： G01N2164
CPC分类号： G01N21/6428 , G01N2021/6432
摘要： Provided is an optical sensor including a support and a detection layer, wherein the detection layer includes: (a) a luminescent material wherein the luminescence intensity of the luminescent material varies as the amount of an analyte varies; (b) a reflective material having a highly efficient reflectance of the wavelengths of excitation and of emission of the luminescent material; and (c) a polymeric binder to support and hold together the luminescent material and the reflective material. Such an optical sensor can be advantageously used in the detection of gaseous, ionic, and nonionic analytes in highly scattering samples. Also provided are methods for the manufacture of such optical sensors.
摘要翻译： 提供了一种包括支撑体和检测层的光学传感器，其中检测层包括：（a）发光材料，其中发光材料的发光强度随着分析物的量的变化而变化;（b）反射材料，其具有 发光材料的激发波长和发射波长的高效反射率; 和（c）聚合物粘合剂，用于支撑和保持发光材料和反射材料。 这种光学传感器可以有利地用于高分散样品中气态，离子和非离子分析物的检测。 还提供了用于制造这种光学传感器的方法。
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公开(公告)号：US4043292A
公开(公告)日：1977-08-23
申请号：US597442
申请日：1975-07-21
CPC分类号： G01N1/312
摘要： Method and apparatus for staining biological specimens by forming a film of staining reagents on the surface of the specimen containing slide. Heating means raises the temperature of the staining reagents on the slide. The temperature of the reagent film is determined, and a feedback signal to the heating means accurately maintains the temperature of the film within a predetermined range.
摘要翻译： 通过在含有载玻片的样品的表面上形成染色剂的膜来染色生物标本的方法和装置。 加热装置提高了载玻片上染色试剂的温度。 确定试剂膜的温度，并且向加热装置的反馈信号将膜的温度精确地维持在预定范围内。
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公开(公告)号：US07157056B2
公开(公告)日：2007-01-02
申请号：US10238946
申请日：2002-09-10
申请人： Kevin J. Sullivan
发明人： Kevin J. Sullivan
IPC分类号： B01L3/02
CPC分类号： B01L3/502715 , B01L3/5025 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2300/087 , B01L2400/0487 , G01N21/11 , G01N2035/00148 , Y10T436/2575
摘要： A sample introduction device is provided that is particularly useful in the critical care environment for the anaerobic withdrawal of small volumes of arterial blood from a sample collection syringe and introduction thereof into a sample chamber of a sensor for analysis. The sample introduction device includes a Luer fitting adapted to mate an outlet of the container in a concentric orientation with an input aperture of the sample chamber. A tubular probe is adapted for concentric placement with both the outlet and inlet aperture, with a first end thereof extending into the syringe and a second end adapted for attachment to an air supply. The probe has a predetermined diameter sufficient to provide an annular clearance between the probe and each of the outlet and inlet aperture. A predetermined volume of air is injected through the probe into the container to displace a predetermined volume of sample therefrom, through the annular clearance into the sample chamber. Injecting air into the syringe through the probe to displace the sample therefrom, rather than drawing the sample into the probe, advantageously reduces or eliminates the need for washing the interior of the probe to relatively reduce the use of wash reagents.
摘要翻译： 提供了一种样品引入装置，其特别可用于从样本采集注射器中将小体积动脉血的厌氧取出并将其引入用于分析的传感器的样品室中的关键护理环境中。 样品引入装置包括适于将容器的出口以同心取向与样品室的输入孔配合的鲁尔接头。 管状探头适于与出口孔和入口孔同心放置，其第一端延伸到注射器中，第二端适于附接到空气源。 探针具有足以在探针与每个出口孔和入口孔之间提供环形间隙的预定直径。 通过探针将预定体积的空气注入容器中，以通过进入样品室的环形间隙将预定体积的样品从其移出。 通过探针将空气注入注射器中以从其中移除样品，而不是将样品拉入探针中，有利地减少或消除了对探针内部进行洗涤以相对减少洗涤试剂的使用的需要。
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10.发明授权公开(公告)号：US06368869B2
公开(公告)日：2002-04-09
申请号：US09775332
申请日：2001-01-31
IPC分类号： G01N2164
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： A liquid permeable metallic coating is utilized in conjunction with a fluorescence based optical sensor. The metallic coating is deposited directly on, and is in physical contact with, the sensing membrane. The metallic coating does not require an intervening substrate layer or other components. When light from a light source is shone through the substantially light transmissive substrate onto the sensing membrane, the metallic overcoating reflects back the excitation light as well as the fluorescence light generated by the sensor such that substantially no light reaches the sample where the light may be scattered and/or absorbed by the sample. Accordingly, the accuracy and repeatability of the sensor is improved while the cost and production times associated with manufacturing the sensor are minimized.
摘要翻译： 液体可渗透的金属涂层与荧光基光学传感器结合使用。 金属涂层直接沉积在感测膜上并与传感膜物理接触。 金属涂层不需要中间衬底层或其它部件。 当来自光源的光通过基本上透光的基底照射到感测膜上时，金属外涂层反射激发光以及由传感器产生的荧光，使得基本上没有光到达光可以是样品 被样品分散和/或吸收。 因此，传感器的精度和重复性得到改善，同时与生产传感器相关的成本和生产时间最小化。
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