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    Optical sensors with reflective materials
    2.
    发明授权
    Optical sensors with reflective materials 失效
    带反光材料的光学传感器

    公开(公告)号：US06254831B1

    公开(公告)日：2001-07-03

    申请号：US09009917

    申请日：1998-01-21

    申请人： Steven M. Barnard ,  Thomas C. Collins ,  Susan L. Cudmore ,  Richard W. Mason ,  Christiane Munkholm ,  Rudolf E. Slovacek ,  Kevin J. Sullivan

    发明人： Steven M. Barnard ,  Thomas C. Collins ,  Susan L. Cudmore ,  Richard W. Mason ,  Christiane Munkholm ,  Rudolf E. Slovacek ,  Kevin J. Sullivan

    IPC分类号： G01N2164

    CPC分类号： G01N21/6428 ,  G01N2021/6432

    摘要： Provided is an optical sensor including a support and a detection layer, wherein the detection layer includes: (a) a luminescent material wherein the luminescence intensity of the luminescent material varies as the amount of an analyte varies; (b) a reflective material having a highly efficient reflectance of the wavelengths of excitation and of emission of the luminescent material; and (c) a polymeric binder to support and hold together the luminescent material and the reflective material. Such an optical sensor can be advantageously used in the detection of gaseous, ionic, and nonionic analytes in highly scattering samples. Also provided are methods for the manufacture of such optical sensors.

    摘要翻译： 提供了一种包括支撑体和检测层的光学传感器，其中检测层包括：（a）发光材料，其中发光材料的发光强度随着分析物的量的变化而变化;（b）反射材料，其具有 发光材料的激发波长和发射波长的高效反射率; 和（c）聚合物粘合剂，用于支撑和保持发光材料和反射材料。 这种光学传感器可以有利地用于高分散样品中气态，离子和非离子分析物的检测。 还提供了用于制造这种光学传感器的方法。

    COMPOSITIONS AND METHODS FOR REPRESENTATIONAL SELECTION OF NUCLEIC ACIDS FROM COMPLEX MIXTURES USING HYBRIDIZATION
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR REPRESENTATIONAL SELECTION OF NUCLEIC ACIDS FROM COMPLEX MIXTURES USING HYBRIDIZATION 有权
    使用混合从复合混合物中代表性选择核酸的组合物和方法

    公开(公告)号：US20100093550A1

    公开(公告)日：2010-04-15

    申请号：US12445069

    申请日：2007-08-24

    申请人： John R. Stuelpnagel ,  David L. Barker ,  Jorge Velarde, JR. ,  Steven M. Barnard ,  Michael Graige

    发明人： John R. Stuelpnagel ,  David L. Barker ,  Jorge Velarde, JR. ,  Steven M. Barnard ,  Michael Graige

    IPC分类号： C40B20/02

    CPC分类号： C12N15/1072 ,  C12Q1/6837 ,  C12Q2565/515

    摘要： The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.001% of the complex mixture, wherein the representational sample comprises a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of the sequences in the predetermined portion of one or more nucleic acids within the complex mixture. A method of selecting a representational sample of genomic sequences from a complete genome also is provided. The invention further provides a nucleic acid population that includes a representational sample having a complexity of less than 10% but more than 0.001% of a complex mixture, the representational sample comprising a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of sequences in a predetermined portion of a sequence collectively present in one or more nucleic acids within the complex mixture.

    摘要翻译： 本发明提供了从复杂混合物中选择核酸序列的表示样品的方法。 该方法包括：（a）在足以与包含与复合物混合物中共同存在的序列的预定部分的一个或多个核酸互补的捕获探针的杂交群的条件下使核酸的复杂混合物接触，以形成杂合复合物 具有探针群的一个或多个核酸，捕获探针的群体连接到固体支持物上，和（b）除去未杂交的核酸以选择复杂度小于10％但更多的核酸的代表性样品 超过0.001％的复合混合物，其中代表性样品包含核酸拷贝，其拷贝中的每个序列的比例相对于拷贝中的所有其它序列基本上与在一个或更多个预定部分中的序列的比例相同 复杂混合物中更多的核酸。 还提供了从完整基因组中选择基因组序列的表示样品的方法。 本发明还提供了一种核酸群体，其包括具有小于复合物混合物的10％但大于0.001％的复杂性的代表性样品，所述代表性样品包含核酸拷贝，所述核酸拷贝具有拷贝中每个序列的比例相对于 拷贝中的所有其它序列基本上与复合物混合物中一个或多个核酸中共存的序列的预定部分中的序列比例相同。

    Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
    9.
    发明授权
    Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample 失效
    使成像光纤传感器同时检测流体样品中感兴趣的多个分析物的方法

    公开(公告)号：US5250264A

    公开(公告)日：1993-10-05

    申请号：US994552

    申请日：1992-12-21

    申请人： David R. Walt ,  Steven M. Barnard

    发明人： David R. Walt ,  Steven M. Barnard

    IPC分类号： G01N21/77 ,  G02B6/06 ,  G01N21/00 ,  A61B5/00 ,  G02B6/24

    CPC分类号： G02B6/06 ,  G01N21/7703 ,  G01N2021/6434 ,  G01N2021/773 ,  G01N2021/7793

    摘要： The present invention provides a unique fiber optic sensor which is able to conduct multiple assays and analyses concurrently using a plurality of different dyes immobilized at individual spatial positions on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

    摘要翻译： 本发明提供了一种独特的光纤传感器，其能够使用固定在传感器表面上的各个空间位置的多种不同染料同时进行多个测定和分析。 本发明还提供用于同时进行多个感兴趣分析物的精确光学测定和测量的装置，并且提供可以针对特定应用和目的与特定参数或其它配体相关联的多个感兴趣分析物的检测方法。