公开(公告)号：US20080267570A1

公开(公告)日：2008-10-30

申请号：US12169602

申请日：2008-07-08

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： G02B6/06

CPC分类号： G02B6/241 ,  A61N5/0603 ,  A61N5/062 ,  G02B6/262

摘要： A light diffusing tip is provided The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

摘要翻译： 提供光扩散尖端。光扩散尖端包括壳体和设置在壳体内的单片光散射介质。 单片光散射介质包括在第一位置处的第一散射区域，具有第一散射特性的散射区域和第二位置处的第二散射区域，第二散射区域具有不同于第一散射特性的第二散射特性，其中 第一散射区域和第二散射区域沿着壳体A的长度的大部分共同延伸。还提供了光漫射施加器。 所述光漫射施加器包括至少一个光波导，耦合到所述至少一个光波导的第一端的第一终端，耦合到光源的第一终端和耦合到所述至少一个光波导的第二端的光漫射末端 一个光波导。

公开(公告)号：US20060104593A1

公开(公告)日：2006-05-18

申请号：US10989894

申请日：2004-11-16

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： G02B6/00

CPC分类号： G02B6/241 ,  A61N5/0603 ,  A61N5/062 ,  G02B6/262

摘要： A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

公开(公告)号：US06459917B1

公开(公告)日：2002-10-01

申请号：US09575591

申请日：2000-05-22

申请人： Ashok Gowda ,  Roger McNichols

发明人： Ashok Gowda ,  Roger McNichols

IPC分类号： A61B800

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150351 ,  A61B5/150839 ,  A61B5/15142 ,  A61B5/6848 ,  A61B5/686 ,  A61B5/6865 ,  A61M39/0247 ,  A61M2039/0258 ,  A61M2039/0261 ,  A61M2039/0276

摘要： A transcutaneous implant having a stable biological seal at the skin interface, obviating the need for puncturing the skin to obtain fluid samples is described. The implant includes an advanced filtration membrane to promote neovascularization which eliminates mass transfer problems by promoting the development of capillary networks with transcapillary mass transfer rates high enough to insure rapid exchange of analyte between blood and the device. Additionally the membrane provides a bioprotective layer which prevents transport of proteins and cellular components into the device.

公开(公告)号：US09237931B2

公开(公告)日：2016-01-19

申请号：US13592280

申请日：2012-08-22

申请人： Ashok Gowda ,  Roger McNichols ,  Charles Houssiere

发明人： Ashok Gowda ,  Roger McNichols ,  Charles Houssiere

IPC分类号： A61B19/00

CPC分类号： A61B90/11 ,  A61B17/00234 ,  A61B90/14 ,  A61B2090/103 ,  A61B2090/3983

摘要： This invention is directed to devices and methods for stereotactic access, and particularly to a frameless stereotactic access device for accessing a body cavity and methods therefor. In general, a stereotactic device may include portions or features for fixing the device to a portion of a patient's body, such as, for example, a skull, such that the device may be generally spatially fixed in relation to the patient's body or part thereof. The stereotactic device may also generally include portions or features for guiding a medical device or other device at a particular trajectory in relation to the patient's body or part thereof.

摘要翻译： 本发明涉及用于立体定向存取的装置和方法，特别涉及用于进入体腔的无框立体定向存取装置及其方法。 通常，立体定向装置可以包括用于将装置固定到患者身体的一部分（例如颅骨）的部分或特征，使得该装置可以相对于患者的身体或其一部分通常在空间上固定 。 立体定向装置还可以通常包括用于在相对于患者身体或其一部分的特定轨迹处引导医疗装置或其它装置的部分或特征。

公开(公告)号：US20080114340A1

公开(公告)日：2008-05-15

申请号：US11555562

申请日：2006-11-01

申请人： Matthew Fox ,  Ashok Gowda ,  Roger McNichols

发明人： Matthew Fox ,  Ashok Gowda ,  Roger McNichols

IPC分类号： A61B18/18

CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61F13/023

摘要： A device includes an outer layer formed of a fluid impermeable polymer film. The outer layer forms an outer major surface of the device. The device also includes a reinforcement layer underlying the outer layer and an adhesive underlying the outer layer. The adhesive forms an annular adhesive surface wherein the device is configured to form a cavity between an inner surface of the device and a dermal surface when the annular adhesive surface is attached to the dermal surface. The device further includes a fluid conduit operable to provide fluid access to the cavity through the outer layer and the reinforcement layer.

摘要翻译： 一种装置包括由流体不可渗透的聚合物膜形成的外层。 外层形成该装置的外主表面。 该装置还包括位于外层下方的加强层和位于外层下方的粘合剂。 所述粘合剂形成环形粘合剂表面，其中所述装置构造成当所述环形粘合剂表面附着到真皮表面时在所述装置的内表面和真皮表面之间形成空腔。 该装置还包括可操作以通过外层和加强层提供流体进入空腔的流体导管。

公开(公告)号：US20080015560A1

公开(公告)日：2008-01-17

申请号：US11777856

申请日：2007-07-13

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： A61B18/18 ,  G02B6/26

CPC分类号： G02B6/241 ,  A61N5/0603 ,  A61N5/062 ,  G02B6/262

摘要： A light diffusing tip is provided The light diff-using tip comprises a housing and a monolithic light scattering medium disposed within the housing The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing A light diff-using applicator also is provided The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diff-using tip coupled to a second end of the at least one optical waveguide.

摘要翻译： 提供光扩散尖端光扩散尖端包括壳体和设置在壳体内的单片光散射介质。单片光散射介质包括在第一位置处的第一散射区域，散射区域具有第一散射特性和 所述第二散射区域具有与所述第一散射特性不同的第二散射特性，其中所述第一散射区域和所述第二散射区域沿着所述壳体A的长度的大部分共同延伸， 还提供了使用施加器。光漫射施加器包括至少一个光波导，耦合到所述至少一个光波导的第一端的第一终端，耦合到光源的第一终端和耦合到光源的光差分使用尖端 所述至少一个光波导的第二端。

公开(公告)号：US20070249917A1

公开(公告)日：2007-10-25

申请号：US11811083

申请日：2007-06-08

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： A61B5/00

CPC分类号： A61B5/0066 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/4795 ,  G01N21/6428 ,  G01N2021/1787 ,  G01N2201/06193 ,  Y10S436/805 ,  Y10T436/144444

摘要： There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and/or, in particular, the substance within the layer(s), may be measured, evaluated and/or analyzed.

公开(公告)号：US07274847B2

公开(公告)日：2007-09-25

申请号：US10989894

申请日：2004-11-16

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： G02B6/06 ,  A61B18/18

CPC分类号： G02B6/241 ,  A61N5/0603 ,  A61N5/062 ,  G02B6/262

摘要： A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

摘要翻译： 提供光扩散尖端。 光扩散尖端包括壳体和布置在壳体内的单片光散射介质。 单片光散射介质包括在第一位置处的第一散射区域，具有第一散射特性的散射区域和第二位置处的第二散射区域，第二散射区域具有不同于第一散射特性的第二散射特性，其中 第一散射区域和第二散射区域沿着壳体的长度的大部分共同延伸。 还提供了光漫射施加器。 光扩散施加器包括至少一个光波导，耦合到所述至少一个光波导的第一端的第一终端，耦合到光源的第一终端和耦合到所述至少一个光波导的第二端的光漫射末端 一个光波导。

公开(公告)号：US07270656B2

公开(公告)日：2007-09-18

申请号：US10703304

申请日：2003-11-07

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： A61B18/18

CPC分类号： A61B18/22 ,  A61B18/20 ,  A61B90/39 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00065 ,  A61B2018/0013 ,  A61B2018/00577 ,  A61B2018/2261 ,  A61B2018/2272 ,  A61N5/0601

摘要： In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

摘要翻译： 在一个实施例中，本发明涉及用于将能量传递给组织的集成装置。 集成设备包括具有远端的壳体和位于壳体内的管状结构，形成管状结构和壳体之间的第一环形空间。 管状结构被配置为接受能量输送部件并被构造成在管状结构和能量输送部件之间形成第二环形部分。 第一环和第二环被配置为相对于壳体的远端彼此连通。

公开(公告)号：US06438397B1

公开(公告)日：2002-08-20

申请号：US09429191

申请日：1999-10-28

申请人： Gerald G. Bosquet ,  Gerald L. Cote ,  Ashok Gowda ,  Roger McNichols ,  Sohi Rastegar

发明人： Gerald G. Bosquet ,  Gerald L. Cote ,  Ashok Gowda ,  Roger McNichols ,  Sohi Rastegar

IPC分类号： A61B500

CPC分类号： A61B5/6865 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459

摘要： A transcutaneous, implantable skin port sensor includes an access component and a sensor component, both of which can be made from inexpensive biocompatible materials. The access component provides a biological seal that forms around the skin port sensor. The sensor component facilitates non-invasive optically based measurement of analytes by providing a window to the body which avoids changes in the optical signal due to variations in skin optics, optical pathlength, ambient temperature and probe pressure. Tissue ingrowth or interstitial fluid in a through portion downstream of the optical window serves as the sample for the non-invasive, optically based measurement.

摘要翻译： 经皮的植入式皮肤端口传感器包括通路部件和传感器部件，两者均可由廉价的生物相容性材料制成。 进入部件提供围绕皮肤端口传感器形成的生物密封。 传感器组件通过向身体提供窗口来促进分析物的非侵入性光学测量，从而避免由于皮肤光学，光程长度，环境温度和探针压力的变化而导致的光信号变化。 在光学窗口下游的通过部分中的组织向内生长或间质液体用作非侵入式光学测量的样品。