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    Catheter with multiple ultrasound radiating members
    3.
    发明授权
    Catheter with multiple ultrasound radiating members 有权
    导管与多个超声波辐射构件

    公开(公告)号：US08192363B2

    公开(公告)日：2012-06-05

    申请号：US11924482

    申请日：2007-10-25

    申请人： Azita Soltani ,  Robert L. Wilcox

    发明人： Azita Soltani ,  Robert L. Wilcox

    IPC分类号： A61B8/00

    CPC分类号： A61N7/022 ,  A61B17/2202 ,  A61N2007/0078

    摘要： A catheter system for delivering ultrasonic energy to a treatment site includes a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end. An ultrasonic assembly is positioned within the treatment zone and provides providing an average longitudinal power density between about 0.2 and about 1.0 W/cm within the treatment zone.

    摘要翻译： 用于将超声能量输送到治疗部位的导管系统包括具有近端，远端和位于远端和近端之间的治疗区的管状体。 超声波组件位于处理区内并且在处理区域内提供约0.2至约1.0W / cm的平均纵向功率密度。

    Catheter with multiple ultrasound radiating members
    6.
    发明授权
    Catheter with multiple ultrasound radiating members 有权
    导管与多个超声波辐射构件

    公开(公告)号：US07828762B2

    公开(公告)日：2010-11-09

    申请号：US11643417

    申请日：2006-12-21

    申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

    发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

    IPC分类号： A61B17/20

    CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

    摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

    摘要翻译： 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体，每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。

    Apparatus for providing coronary retroperfusion and methods of use
    7.
    发明授权
    Apparatus for providing coronary retroperfusion and methods of use 有权
    用于提供冠状动脉灌注灌注和使用方法的装置

    公开(公告)号：US07083588B1

    公开(公告)日：2006-08-01

    申请号：US09320172

    申请日：1999-05-26

    申请人： Ascher Shmulewitz ,  John Burton ,  Robert S. Bley ,  Roy Singfatt Chin ,  Ronald C. Brown ,  Robert L. Wilcox

    发明人： Ascher Shmulewitz ,  John Burton ,  Robert S. Bley ,  Roy Singfatt Chin ,  Ronald C. Brown ,  Robert L. Wilcox

    IPC分类号： A61M5/00

    CPC分类号： A61M1/3621 ,  A61B17/0057 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1037 ,  A61M1/1081 ,  A61M1/1087 ,  A61M1/1096 ,  A61M1/12 ,  A61M1/3613 ,  A61M25/04 ,  A61M2205/32 ,  A61M2210/125

    摘要： Apparatus and methods for perfusing ischemic myocardium, and optionally, for reducing the load on a patient's left ventricle, are provided using a inlet conduit having an inlet end configured for insertion into an oxygenated blood source, including without limitation, the left atrium, left ventricle, aorta, pulmonary vein, subclavian artery, brachiocephalic artery, radial artery or femoral artery, coupled to an outlet conduit having an outlet end configured for insertion into the coronary venous vasculature via the coronary ostium. The inlet conduit may include a stylet or elastomeric sleeve that facilitates placement, while the outlet conduit may include a valve for limiting a peak pressure attained in the coronary venous system. A motor-driven or hydraulically-actuated pump optionally may be coupled in the flow path, and control circuitry provided to control the pump with a user selected duty cycle.

    摘要翻译： 用于灌注缺血心肌的装置和方法以及任选的用于减轻患者左心室负荷的装置和方法使用入口导管提供，所述入口导管具有被配置用于插入氧合血液源的入口端，包括但不限于左心房，左心室 主动脉，肺静脉，锁骨下动脉，头臂动脉，桡动脉或股动脉，联接到具有经由冠状口插入冠状静脉血管的出口端的出口导管。 入口导管可以包括便于放置的探针或弹性体套筒，而出口导管可以包括用于限制在冠状静脉系统中获得的峰值压力的阀。 可选地，电动驱动或液压致动的泵耦合在流动路径中，以及控制电路，其被提供以用用户选择的占空比来控制泵。

    Blood flow reestablishment determination
    8.
    发明授权
    Blood flow reestablishment determination 有权
    血流重建确定

    公开(公告)号：US06979293B2

    公开(公告)日：2005-12-27

    申请号：US10320847

    申请日：2002-12-16

    申请人： Douglas R. Hansmann ,  Robert L. Wilcox ,  Floyd Karp ,  Natalya Peskin ,  Kim R. Volz

    发明人： Douglas R. Hansmann ,  Robert L. Wilcox ,  Floyd Karp ,  Natalya Peskin ,  Kim R. Volz

    IPC分类号： A61B5/028 ,  A61B8/12 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B8/00

    CPC分类号： A61B17/22012 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2017/22021 ,  A61B2017/22082 ,  A61B2017/22084

    摘要： A method for monitoring a clot dissolution treatment in a patient's vasculature comprises positioning a catheter at a treatment site in the patient's vasculature. The method further comprises performing a clot dissolution treatment at the treatment site. The clot dissolution treatment comprises delivering ultrasonic energy and a therapeutic compound from the catheter to the treatment site such that a clot located at the treatment site at least partially dissolves. The method further comprises delivering a thermal measurement signal from a first portion of the catheter to the treatment site during the clot dissolution treatment. The method further comprises receiving the thermal measurement signal at a second portion of the catheter. The method further comprises comparing the delivered thermal measurement signal with the received thermal measurement signal to evaluate a blood flow rate at the treatment site.

    摘要翻译： 用于监测患者脉管系统中的凝块溶解治疗的方法包括将导管定位在患者脉管系统的治疗部位。 该方法还包括在治疗部位进行凝块溶解处理。 凝块溶解处理包括将超声能量和治疗化合物从导管输送到治疗部位，使得位于治疗部位的血块至少部分溶解。 该方法还包括在凝块溶解治疗期间将热测量信号从导管的第一部分输送到治疗部位。 该方法还包括在导管的第二部分处接收热测量信号。 该方法还包括比较传送的热测量信号与接收的热测量信号，以评估处理部位的血液流速。

    Catheter movement control device and method
    9.
    发明授权
    Catheter movement control device and method 失效

    公开(公告)号：US06638269B2

    公开(公告)日：2003-10-28

    申请号：US10131874

    申请日：2002-04-25

    申请人： Robert L. Wilcox

    发明人： Robert L. Wilcox

    IPC分类号： A61M500

    CPC分类号： A61M25/0111 ,  A61M25/002 ,  A61M2210/1089

    摘要： A catheter movement control device is provided which allows forward, extending movement of the catheter tube contained within a flexible package to the exterior thereof as required during insertion. The method of use includes moving the catheter tube through the control device to exit the catheter package where it is inserted into the urethra. If resistance is encountered during insertion a stop member firmly engages the catheter tube to prevent rearward movement of the catheter tube under normal urging.