公开(公告)号：US09885017B2

公开(公告)日：2018-02-06

申请号：US14152448

申请日：2014-01-10

Applicant: Baylor Research Institute ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

Inventor： Helene Dutartre ,  Yves Levy ,  Jacques Banchereau ,  Gerard Zurawski

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/28 ,  A61P37/04 ,  C12N5/0784 ,  A61K39/29 ,  A61K39/12 ,  C07K14/005

CPC classification number: C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

公开(公告)号：US12016915B2

公开(公告)日：2024-06-25

申请号：US17454108

申请日：2021-11-09

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： SangKon Oh ,  Dapeng Li ,  Jacques Banchereau ,  Gerard Zurawski ,  Sandra Zurawski

IPC: A61K39/145 ,  A61K39/00 ,  A61K47/68 ,  A61K51/10 ,  C07K14/005 ,  C07K14/195 ,  C07K14/37 ,  C07K14/405 ,  C07K14/435 ,  C07K16/28 ,  C12N5/0784 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K47/6849 ,  A61K51/1027 ,  C07K14/005 ,  C07K14/195 ,  C07K14/37 ,  C07K14/405 ,  C07K14/435 ,  C07K16/28 ,  C12N5/0639 ,  C12N7/00 ,  A61K2039/5154 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/92 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.

公开(公告)号：US20250018025A1

公开(公告)日：2025-01-16

申请号：US18670211

申请日：2024-05-21

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： SangKon OH ,  Dapeng LI ,  Jacques Banchereau ,  Gerard Zurawski ,  Sandra Zurawski

IPC: A61K39/145 ,  A61K39/00 ,  A61K47/68 ,  A61K51/10 ,  C07K14/005 ,  C07K14/195 ,  C07K14/37 ,  C07K14/405 ,  C07K14/435 ,  C07K16/28 ,  C12N5/0784 ,  C12N7/00

Abstract: The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.

公开(公告)号：US20140199763A1

公开(公告)日：2014-07-17

申请号：US14152448

申请日：2014-01-10

Applicant: Institut National de la Sante et de la Recherche Medicale ( INSERM) ,  Baylor Research Institute

Inventor： Helene Dutartre ,  Yves Levy ,  Jacques Banchereau ,  Gerard Zurawski

IPC: C12N5/0784

CPC classification number: C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

Abstract translation: 本文描述了包含与针对树突状细胞（DC）特异性的抗体的重链和/或轻链或其片段融合的丙型肝炎病毒（HCV）蛋白或其片段的病毒抗原和抗原肽的组合物。 本文包括免疫刺激组合物（HCV疫苗，呈递树突细胞的HCV抗原等）以及用于增加抗原呈递细胞的HCV抗原呈递的有效性的方法，用于治疗，预防或其组合以抗人类受试者中的丙型肝炎 ，以及通过激活一种或多种树突状细胞提供免疫刺激的方法，治疗或预防丙型肝炎的方法。