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公开(公告)号：US11219683B2
公开(公告)日：2022-01-11
申请号：US16946390
申请日：2020-06-19
申请人： INSERM (Institut National de la Santé et de la Recherche Mêdicale) , Baylor Research Institute , Universite Paris Est Creteil Val De Marne , Assistance Publique Hopitaux de Paris
发明人： Yves Levy , Gerard Zurawski , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61P31/18 , C07K14/005 , C12N7/00 , C07K16/28 , C07K16/10
摘要： Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).
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公开(公告)号：US20190184008A1
公开(公告)日：2019-06-20
申请号：US16141157
申请日：2018-09-25
申请人： INSERM (Institut National de la Santé et de la Recherche Mêdicale , Baylor Research Institute , Universite Paris Est Creteil Val De Marne , Assistance Publique Hopitaux de Paris
发明人： Yves Levy , Gerard Zurawski , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/21 , C07K16/28 , A61P31/18 , C07K14/005 , C12N7/00
CPC分类号： A61K39/21 , A61K2039/505 , A61K2039/572 , A61K2039/575 , A61K2039/6056 , A61K2039/627 , A61P31/18 , C07K14/005 , C07K16/2878 , C07K2317/24 , C07K2317/732 , C07K2319/02 , C07K2319/40 , C12N7/00 , C12N2740/16134 , C12N2740/16171
摘要： Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).
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公开(公告)号：US10722572B2
公开(公告)日：2020-07-28
申请号：US16708787
申请日：2019-12-10
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Baylor Research Institute , Universite Paris Est Creteil Val De Marne , Assistance Publique Hopitaux de Paris
发明人： Yves Levy , Gerard Zurawski , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61K39/12 , A61K39/21 , C07K14/005 , C12N7/00 , C07K16/10 , A61P31/18
摘要： Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).
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4.发明申请MULTIVARIABLE ANTIGENS COMPLEXED WITH TARGETING HUMANIZED MONOCLONAL ANTIBODY 审中-公开与靶向人类单克隆抗体复合的多重抗体公开(公告)号：US20160031988A1
公开(公告)日：2016-02-04
申请号：US14887151
申请日：2015-10-19
CPC分类号： C07K16/28 , A61K39/44 , C07K14/33 , C07K16/00 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C07K2319/33
摘要： The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.
摘要翻译： 本发明包括用于设计，制造和使用模块化重组抗体或其片段的组合物和方法，所述重组抗体或其片段具有允许多变抗原缀合物的快速装配的粘稠素 - 停泊聚糖对的一半。
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公开(公告)号：US20150299329A1
公开(公告)日：2015-10-22
申请号：US14610456
申请日：2015-01-30
IPC分类号： C07K16/28 , C07K16/00 , C07K14/005
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/385 , A61K2039/6056 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K16/00 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/77 , C07K2317/80 , C07K2319/00 , C07K2319/30 , C07K2319/40 , C07K2319/91 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222 , C12N2770/24234 , G01N33/6863 , Y02A50/39 , Y02A50/464 , Y02A50/466
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
摘要翻译： 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。
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公开(公告)号：US10988544B2
公开(公告)日：2021-04-27
申请号：US15787425
申请日：2017-10-18
IPC分类号： C07K16/28 , C07K14/005 , A61K39/385 , G01N33/68 , C07K16/00 , A61K39/00
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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公开(公告)号：US11806390B2
公开(公告)日：2023-11-07
申请号：US17301704
申请日：2021-04-12
发明人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Peter Klucar , Keiko Akagawa , Sandra Zurawski , SangKon Oh
IPC分类号： A61K39/00 , A61K39/385 , C07K14/005 , C07K16/00 , G01N33/68 , C07K16/28 , C07K14/435
CPC分类号： A61K39/001129 , A61K39/385 , C07K14/005 , C07K14/435 , C07K16/00 , C07K16/2878 , G01N33/6863 , A61K39/00 , A61K2039/6056 , A61K2039/627 , A61K2039/64 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/77 , C07K2317/80 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/40 , C07K2319/91 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222 , C12N2770/24234 , Y02A50/30
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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公开(公告)号：US09234040B2
公开(公告)日：2016-01-12
申请号：US14045454
申请日：2013-10-03
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/21 , A61K39/145 , A61K39/04 , A61K39/39 , A61K39/395 , C07K16/28 , A61K39/02 , A61K39/12 , A61K47/48 , B82Y5/00 , C12N5/0784 , A61K39/00
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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9.发明授权Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells 有权基于在抗原呈递细胞上表达的针对DCIR的靶向抗原的疫苗公开(公告)号：US09102730B2
公开(公告)日：2015-08-11
申请号：US13872793
申请日：2013-04-29
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/12 , A61K39/145 , A61K39/21 , A61K39/395 , C07K16/46 , C07K16/28 , B82Y5/00 , A61K47/48 , C12N5/0784 , A61K39/02 , A61K39/00
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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10.发明申请VACCINES BASED ON TARGETING ANTIGEN TO DCIR EXPRESSED ON ANTIGEN-PRESENTING CELLS 有权基于抗原向抗原呈递细胞表达的DCIR的抗生素疫苗公开(公告)号：US20130295120A1
公开(公告)日：2013-11-07
申请号：US13872793
申请日：2013-04-29
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： C07K16/28 , C12N5/0784
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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