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公开(公告)号:US11304798B2
公开(公告)日:2022-04-19
申请号:US16413104
申请日:2019-05-15
Applicant: Boston Scientific Scimed, Inc.
Inventor: David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, Jr. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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公开(公告)号:US20160296323A1
公开(公告)日:2016-10-13
申请号:US15082382
申请日:2016-03-28
Applicant: Boston Scientific SciMed, Inc.
Inventor: David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, JR. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
CPC classification number: A61F2/2412 , A61F2/2415 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/52 , A61L2400/12 , A61L2420/02 , A61L2420/08 , A61L2430/20 , C08L71/02
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
Abstract translation: 假体心脏瓣膜小叶包括至少部分地嵌入聚合物基质中的多个电纺纤维。 多根纤维包括具有第一预定重量百分比的硬链段部分的第一聚异丁烯氨基甲酸酯共聚物,聚合物基质包括具有第二预定重量百分比的硬链段部分的第二聚异丁烯聚氨酯共聚物,其中第一预定重量平均值 硬段部分的百分比大于硬段部分的第二预定重量平均百分比。
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公开(公告)号:US09901384B2
公开(公告)日:2018-02-27
申请号:US15083720
申请日:2016-03-29
Applicant: Boston Scientific Scimed, Inc.
Inventor: Bryan Allen Clark , Aiden Flanagan , Michael Eppihimer , William Conrad Stoffregen , Juan Gabriel Hincapie Ordonez
CPC classification number: A61B18/00 , A61B5/08 , A61B5/4836 , A61B5/4848 , A61B5/4884 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B18/1492 , A61B2018/00434 , A61B2018/00541 , A61B2018/00642 , A61N1/0519 , A61N1/3601 , A61N1/36053 , A61N1/3611
Abstract: A medical device may include a stimulation member configured to apply a stimulus to a nerve that is configured to control a contraction of an airway distal to the nerve, and a measurement member configured to measure an effect of the stimulus on the airway. The medical device also may include an energy delivery element configured to deliver energy to tissue defining the airway to reduce an effect of the stimulus on the airway. The energy delivery element may be disposed at or distally of the stimulation member.
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公开(公告)号:US11172921B2
公开(公告)日:2021-11-16
申请号:US16313441
申请日:2016-12-16
Inventor: James P. Rohl , Mary M. Byron , David R. Wulfman , James K. Cawthra, Jr. , Devon N. Arnholt , Michael Eppihimer , David J. Lehse , Katherine Lorraine Baldwin , Joseph A. Dearani , Peter M. Pollak
IPC: A61B17/04 , A61F2/24 , A61B17/122 , A61B17/00 , A61B17/128
Abstract: A heart valve anchor has a body that includes a distal portion, a distal end, a proximal portion, and a proximal end. The distal end and the proximal end define a longitudinal axis. The body has an expandable portion that includes a first radially expandable portion at the distal portion of the body, a second radially expandable portion at the proximal portion of the body, and a root portion disposed between the first and second radially expandable portions. The body has a first configuration adapted to be housed at least partially within a tissue penetrating device, and a second configuration in which the first and second radially expandable portions are partially or fully expanded such that the anchor engages tissue in a region between the first and second radially expandable portions.
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公开(公告)号:US10716671B2
公开(公告)日:2020-07-21
申请号:US15193794
申请日:2016-06-27
Applicant: Boston Scientific SciMed, Inc.
Inventor: Michael Eppihimer , Peter G. Edelman
IPC: A61F2/24
Abstract: A prosthetic heart leaflet includes a fiber-reinforced structure including a plurality of composite fibers. Each composite fiber includes a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape.
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公开(公告)号:US10136936B2
公开(公告)日:2018-11-27
申请号:US15868176
申请日:2018-01-11
Applicant: Boston Scientific Scimed, Inc.
Inventor: Bryan Allen Clark , Aiden Flanagan , Michael Eppihimer , William Conrad Stoffregen , Juan Gabriel Hincapie Ordonez
Abstract: A medical device may include a stimulation member configured to apply a stimulus to a nerve that is configured to control a contraction of an airway distal to the nerve, and a measurement member configured to measure an effect of the stimulus on the airway. The medical device also may include an energy delivery element configured to deliver energy to tissue defining the airway to reduce an effect of the stimulus on the airway. The energy delivery element may be disposed at or distally of the stimulation member.
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公开(公告)号:US20170112477A1
公开(公告)日:2017-04-27
申请号:US15297622
申请日:2016-10-19
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor: Christopher A. Benning , Andrew T. Brown , John B. Golden , Michael Eppihimer , Paul Smith , Gerald Fredrickson
CPC classification number: A61B10/02 , A61B10/04 , A61B2010/0216 , G01N1/30 , G01N2001/305
Abstract: Medical devices and methods are disclosed in the present application. In one illustrative example a cell sample collection device may comprise an elongated shaft extending from a proximal end to a distal end and a tissue collection feature extending distal of the distal end of the elongated shaft. In at least some additional embodiments, at least a portion of the tissue collection feature may dissolve when placed in a fixation medium.
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公开(公告)号:US10405975B2
公开(公告)日:2019-09-10
申请号:US15272747
申请日:2016-09-22
Applicant: Boston Scientific SciMed, Inc.
Inventor: Crystal Marie Anderson-Cunanan , Katherine Cora Fazackerley , Michael Eppihimer , Shannon Smith Kenwood , Natalia P. Sushkova , Karen Suzanne Lavery
Abstract: A prosthetic heart valve provided herein can include a cultured cell tissue leaflet. In some cases, a prosthetic heart valve can include a plurality of leaflets secured together and retained within the expandable tubular member. The cultured cell tissue can be obtained by culturing fibroblast cells, smooth muscle cells, or a combination thereof to form a sheet of cultured cells and chemically cross-linking the fibroblast cells while under tension. In some cases, the cultured cell tissue can be radially tensioned. In some cases, the cultured cell tissue can be bi-axially tensioned.
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公开(公告)号:US20190262131A1
公开(公告)日:2019-08-29
申请号:US16413104
申请日:2019-05-15
Applicant: Boston Scientific Scimed, Inc.
Inventor: David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, JR. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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公开(公告)号:US10314696B2
公开(公告)日:2019-06-11
申请号:US15082382
申请日:2016-03-28
Applicant: Boston Scientific SciMed, Inc.
Inventor: David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, Jr. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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