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公开(公告)号：US20240043643A1
公开(公告)日：2024-02-08
申请号：US18221595
申请日：2023-07-13
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney , Paul Vincent Grosso , Patrick Willoughby
CPC classification number: C08J7/12 , A61L31/10 , C08J2375/14
Abstract: A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.
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公开(公告)号：US20180303972A1
公开(公告)日：2018-10-25
申请号：US15959894
申请日：2018-04-23
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
CPC classification number: A61L27/16 , A61L27/48 , A61L2430/20 , C08J3/246 , C08J2323/22 , C08J2337/00 , C08J2479/02 , C08L53/00 , C08L2203/02 , C08L23/22
Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US20160296323A1
公开(公告)日：2016-10-13
申请号：US15082382
申请日：2016-03-28
Applicant: Boston Scientific SciMed, Inc.
Inventor： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, JR. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
CPC classification number: A61F2/2412 , A61F2/2415 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/52 , A61L2400/12 , A61L2420/02 , A61L2420/08 , A61L2430/20 , C08L71/02
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
Abstract translation: 假体心脏瓣膜小叶包括至少部分地嵌入聚合物基质中的多个电纺纤维。 多根纤维包括具有第一预定重量百分比的硬链段部分的第一聚异丁烯氨基甲酸酯共聚物，聚合物基质包括具有第二预定重量百分比的硬链段部分的第二聚异丁烯聚氨酯共聚物，其中第一预定重量平均值 硬段部分的百分比大于硬段部分的第二预定重量平均百分比。
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公开(公告)号：US20250025180A1
公开(公告)日：2025-01-23
申请号：US18776952
申请日：2024-07-18
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Patrick Willoughby
Abstract: A left atrial appendage closure device adapted for occluding the left atrial appendage includes a cone-shaped insert formed of an expandable foam and adapted for trans-septal delivery to the LAA. A polymeric covering is disposed over the cone-shaped insert, the polymeric covering adapted to protect the cone-shaped insert during trans-septal delivery to the LAA, the polymeric covering adapted for removal after trans-septal delivery to the LAA. An insert lumen extends through the cone-shaped insert prior to expansion of the cone-shaped insert. A tubular support rod extends through the insert lumen, the tubular support rod operably coupled with at least a portion of the polymeric covering, the tubular support rod itself defining a tubular support rod lumen adapted to accommodate a guidewire over which the insert may be advanced into the LAA and/or a radio frequency (RF) energy wire adapted for making a trans-septal puncture.
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公开(公告)号：US11304798B2
公开(公告)日：2022-04-19
申请号：US16413104
申请日：2019-05-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, Jr. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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Patent Agency Ranking
公开(公告)号：US20250072960A1
公开(公告)日：2025-03-06
申请号：US18816787
申请日：2024-08-27
Applicant: Boston Scientific Scimed, Inc.
Inventor： Patrick Willoughby , Emily Vance , Trey Henry Achterhoff , Thomas Grant , Scott Andrew McCullough
Abstract: A medical device includes an elongate hollow shaft having a shaft proximal end, a shaft distal end, and a lumen extending along the elongate hollow shaft. A handle is disposed at the shaft proximal end. A connector assembly having a connector assembly proximal end and a connector assembly distal end, the connector assembly proximal and distal ends being opposite ends of the connector assembly. An expandable frame is detachably disposed at the connector assembly distal end, the expandable frame including a plurality of interconnected members formed of an electrically conductive material, wherein the interconnected members in a first portion of the expandable frame are coated with a dielectric layer, and wherein the interconnected members in a second portion of the expandable frame are uncoated and configured as an electrode region of the expandable frame.
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公开(公告)号：US20210170069A1
公开(公告)日：2021-06-10
申请号：US17179971
申请日：2021-02-19
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US10925998B2
公开(公告)日：2021-02-23
申请号：US15959894
申请日：2018-04-23
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, Jr. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
IPC: C08J3/24 , C08J7/04 , C08J7/056 , C08L23/18 , C08L23/22 , D01D5/08 , D01D5/18 , D02G3/36 , A61L27/16 , C08L53/00 , A61L27/48 , D01D5/00 , D01D5/098
Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US20190262131A1
公开(公告)日：2019-08-29
申请号：US16413104
申请日：2019-05-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, JR. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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公开(公告)号：US10314696B2
公开(公告)日：2019-06-11
申请号：US15082382
申请日：2016-03-28
Applicant: Boston Scientific SciMed, Inc.
Inventor： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, Jr. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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