公开(公告)号：US06533380B1

公开(公告)日：2003-03-18

申请号：US09954308

申请日：2001-09-12

申请人： Babur B. Hadimioglu ,  Richard N. Ellson

发明人： Babur B. Hadimioglu ,  Richard N. Ellson

IPC分类号： B41J2145

CPC分类号： B41J2/2139 ,  B41J2/0451 ,  B41J2/04525 ,  B41J2/04575 ,  B41J2/04595

摘要： An at least two-pass acoustic printing system uses an acoustic printhead having an array of ejectors arranged in rows and columns. Operation of each ejector is individually controllable. To minimize cross-talk errors a first selected ejector in a selected row is identified as an odd ejector of the selected row. Thereafter a first firing sequence of the first selected ejector is generated based on the first selected ejector being identified as odd. Then a second ejector, immediately adjacent the first ejector, is selected and is identified as an even ejector. Thereafter a second firing sequence is generated for the second selected ejector based on the selector being identified as even. The first and second firing sequences result in the first ejector and the second ejector being active during non-concurrent time periods. When a defective ejector of the array is detected, an operable ejector firing to the same substrate area is determined. A firing sequence from or associated with the defective ejector is transferred to be used by the operable ejector wherein the operable ejector fires both its own firing sequence and the firing sequence of the defective ejector.

摘要翻译： 至少两声道声音打印系统使用具有排列成行和列的排列阵列的声学打印头。 每个喷射器的操作是可以单独控制的。 为了最小化串扰错误，所选行中的第一选择的喷射器被识别为所选行的奇数喷射器。 此后，基于第一选择的喷射器被识别为奇数来生成第一选择的喷射器的第一喷射序列。 然后选择紧邻第一喷射器的第二喷射器，并被识别为均匀喷射器。 此后，基于选择器被识别为偶数，为第二选择的喷射器生成第二点火序列。 第一和第二发射序列导致第一喷射器和第二喷射器在非并发时间段期间是活动的。 当检测到阵列的有缺陷的喷射器时，确定对相同基板区域的可操作的喷射器发射。 来自或与有缺陷的喷射器相关联的发射序列被转移以由可操作的喷射器使用，其中可操作的喷射器触发其自身的击发序列和有缺陷的喷射器的击发序列。

公开(公告)号：US20110277425A1

公开(公告)日：2011-11-17

申请号：US13105790

申请日：2011-05-11

申请人： Richard N. Ellson

发明人： Richard N. Ellson

IPC分类号： B65B7/28

CPC分类号： C12M23/34 ,  B01L3/508 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/0809 ,  B01L2300/0829 ,  C12M23/10 ,  C12M23/12 ,  C12M23/26 ,  C12M23/38

摘要： In a preferred embodiment of the invention, a closure for a container comprises at least two closure members. The relative position of the closure members with respect to each other is altered upon mating of the closure and container. The alteration of the relative position of the closure members may result in one or more of the members approaching the container more closely. The alteration may result in one or more of the members pressing against the container. The pressing may take place in such a way that exit paths for vapor from fluid in the container would require passage through the pressed surfaces.

摘要翻译： 在本发明的优选实施例中，用于容器的封闭件包括至少两个闭合构件。 封闭件相对于彼此的相对位置在封盖和容器配合时被改变。 关闭构件的相对位置的改变可能导致一个或多个构件更接近容器。 改变可能导致一个或多个构件压靠容器。 按压可以以这样一种方式进行：用于来自容器中的流体的蒸气的出口路径将需要通过压制表面。

公开(公告)号：US07901039B2

公开(公告)日：2011-03-08

申请号：US11487062

申请日：2006-07-13

申请人： Mitchell W. Mutz ,  Richard N. Ellson

发明人： Mitchell W. Mutz ,  Richard N. Ellson

IPC分类号： B41J2/135 ,  C07K2/00

CPC分类号： B41J2/14008 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B05B17/0615 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

摘要： The present invention relates to arrays of peptidic molecules and the preparation of peptide arrays using focused acoustic energy. The arrays are prepared by acoustically ejecting peptide-containing fluid droplets from individual reservoirs towards designated sites on a substrate for attachment thereto.

摘要翻译： 本发明涉及肽分子的阵列和使用聚焦声能的肽阵列的制备。 阵列通过将含有肽的流体液滴从各个储存器喷射到衬底上用于附着于其上的指定位点来制备。

公开(公告)号：US07900505B2

公开(公告)日：2011-03-08

申请号：US11329817

申请日：2006-01-10

申请人： Mitchell W. Mutz ,  Richard N. Ellson ,  James K. Foote

发明人： Mitchell W. Mutz ,  Richard N. Ellson ,  James K. Foote

IPC分类号： G01N29/00

CPC分类号： G01N29/028 ,  G01N11/10 ,  G01N29/032 ,  G01N29/222 ,  G01N2291/02416 ,  G01N2291/048 ,  G01N2291/102

摘要： The invention provides devices and methods for acoustically assessing the contents in a plurality of reservoirs. Each reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. The invention is particularly suited for assessing the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.

摘要翻译： 本发明提供用于声学评估多个储存器中的内容物的装置和方法。 每个储存器具有适于容纳流体的部分，并且声辐射发生器被定位成与每个储存器的声耦合关系。 由声辐射发生器产生的声辐射通过至少每个储存器的部分传输到分析器。 分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。 本发明特别适用于评估多个储存器的内容物，以便准确地控制流体的分配。

公开(公告)号：US06869551B2

公开(公告)日：2005-03-22

申请号：US10244128

申请日：2002-09-13

申请人： David Soong-Hua Lee ,  Richard N. Ellson ,  Theodore J. Williams

发明人： David Soong-Hua Lee ,  Richard N. Ellson ,  Theodore J. Williams

IPC分类号： A61J3/06 ,  A61K9/12 ,  A61K9/16 ,  A61K9/72 ,  B01J2/00 ,  B01J2/02 ,  B01J2/04 ,  B01J2/06 ,  B01J19/10 ,  B05B17/04 ,  B29B9/00

CPC分类号： A61K9/1688 ,  A61K9/122 ,  B01J2/02 ,  B01J2/04

摘要： Methods and devices are disclosed that use focused acoustic energy to generate solid particles containing at least one compound of interest. Focused acoustic radiation serves to eject droplets containing a compound of interest dissolved in a solvent. The droplets are subjected to a condition that allows for the compound of interest to precipitate out of solution, thereby generating solid particles. The particles are typically of controlled size, composition, and/or structure. Often, particles of substantially identical size are generated.

摘要翻译： 公开了使用聚焦声能产生含有至少一种目的化合物的固体颗粒的方法和装置。 聚焦的声辐射用于喷射含有溶解在溶剂中的目的化合物的液滴。 使液滴经受允许感兴趣的化合物沉淀出溶液的条件，从而产生固体颗粒。 颗粒通常具有受控的尺寸，组成和/或结构。 通常，产生基本相同尺寸的颗粒。

公开(公告)号：US06806051B2

公开(公告)日：2004-10-19

申请号：US09962731

申请日：2001-09-24

申请人： Richard N. Ellson

发明人： Richard N. Ellson

IPC分类号： C12Q168

CPC分类号： C07H21/00 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/0036 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  C07B2200/11 ,  C40B40/06 ,  C40B60/14

摘要： Partially nonhybridizing oligonucleotides are provided that contain two or more hybridizing segments, with any two hybridizing segments separated by a nonhybridizing spacer segment, i.e., a nucleotidic or nonnucleotidic segment that has little or no likelihood of binding to an oligonucleotide sequence found in nature. Oligonucleotide arrays are also provided in which at least one of the oligonucleotides of the array is a partially nonhybridizing oligonucleotide. The partially nonhybridizing oligonucleotides serve as multifunctional probes wherein each hybridizing segment of a single partially nonhybridizing oligonucleotide serves as an individual probe. Also provided are methods for preparing and using the partially nonhybridizing oligonucleotides and arrays formed therewith. A particularly preferred method of array fabrication involves the use of focused acoustic energy.

摘要翻译： 提供了部分非杂交寡核苷酸，其含有两个或更多个杂交片段，任意两个杂交片段由非杂交间隔区段分离，即与天然存在的寡核苷酸序列结合很少或不可能结合的核苷酸或非核苷酸片段。 还提供寡核苷酸阵列，其中阵列的至少一个寡核苷酸是部分非杂交寡核苷酸。 部分非杂交寡核苷酸用作多功能探针，其中单个部分非杂交寡核苷酸的每个杂交片段用作单个探针。 还提供了制备和使用部分非杂交寡核苷酸和由其形成的阵列的方法。 阵列制造的特别优选的方法包括使用聚焦的声能。

公开(公告)号：US06707038B2

公开(公告)日：2004-03-16

申请号：US10157755

申请日：2002-05-28

申请人： Richard N. Ellson ,  Mitchell W. Mutz ,  Richard Michael Caprioli

发明人： Richard N. Ellson ,  Mitchell W. Mutz ,  Richard Michael Caprioli

IPC分类号： H01J4904

CPC分类号： H01J49/0454 ,  G01N33/54393 ,  G01N35/1011 ,  H01J49/0004 ,  Y10T436/2575

摘要： A method for selectively depositing analysis-enhancing fluid on a sample surface is disclosed. The method involves providing a sample having a surface that exhibits variations in a surface characteristic that corresponds to desirability for receiving an analysis-enhancing fluid. Once a site on the sample surface is selected according to the surface characteristic at the site, focused radiation, typically acoustic radiation, is applied in a manner effective to eject a droplet of the analysis-enhancing fluid from a reservoir. As a result, the droplet is deposited on the sample surface at the selected site. Optionally, the sample at the selected site is analyzed. Systems for selectively depositing analysis-enhancing fluids are also disclosed.

摘要翻译： 公开了一种用于在样品表面上选择性地沉积分析增强流体的方法。 该方法包括提供具有表现出表现出与分析增强流体接受的期望性相对应的表面特性变化的样品的样品。 一旦根据现场的表面特征选择样品表面上的部位，则以有效地从储存器喷射分析增强流体液滴的方式施加聚焦辐射（通常是声辐射）。 结果，液滴在所选择的位置沉积在样品表面上。 任选地，分析所选位点处的样品。 还公开了用于选择性沉积分析增强流体的系统。

公开(公告)号：US06428159B1

公开(公告)日：2002-08-06

申请号：US09357015

申请日：1999-07-19

申请人： Joy Roy ,  Babur Hadimioglu ,  Richard N. Ellson ,  Robert Sprague ,  James B. Kruger ,  John Lennon

发明人： Joy Roy ,  Babur Hadimioglu ,  Richard N. Ellson ,  Robert Sprague ,  James B. Kruger ,  John Lennon

IPC分类号： B41J201

CPC分类号： B41J11/002

摘要： An apparatus for ink-jet printing on a recording medium is provided which includes the steps of jetting aqueous ink drops on paper in the form of an image. The aqueous ink used is a slow-drying (high-surface tension) ink which does not penetrate the paper/paper fibers for a relatively long time. Prior to penetration of the paper/paper fibers, the water in the droplet is quickly evaporated from the ink while still resident on the paper surface. The evaporation process is substantially completed prior to an additional liquid ink being jetted onto the same or adjoining location of the recording medium. The evaporation is rapid enough to prevent the resident ink from substantially migrating/wicking to any adjacent location or into the recording medium. Further the drying energy is transferred to the resident ink spots from the same direction as the printheads ensuring less energy requirement.

摘要翻译： 提供了一种用于在记录介质上进行喷墨打印的设备，其包括以图像形式将水性墨滴喷射在纸上的步骤。 使用的水性油墨是一种慢干（高表面张力）油墨，其不会在相对长的时间内渗透纸/纸纤维。 在纸/纸纤维渗透之前，液滴中的水从墨水中迅速蒸发，同时仍然驻留在纸张表面上。 在附加的液体墨水喷射到记录介质的相同或相邻位置之前，蒸发过程基本上完成。 蒸发速度足够快以防止驻留的墨水基本上迁移/吸附到任何相邻位置或记录介质中。 此外，干燥能量从与打印头相同的方向转移到驻留的墨点，确保较少的能量需求。

公开(公告)号：US06416164B1

公开(公告)日：2002-07-09

申请号：US09910690

申请日：2001-07-20

申请人： Richard G. Stearns ,  Richard N. Ellson

发明人： Richard G. Stearns ,  Richard N. Ellson

IPC分类号： B41J204

CPC分类号： B41J2/14008

摘要： The present invention provides a method and device for the acoustic ejection of fluid droplets from fluid-containing reservoirs using focusing means having an F-number greater than approximately 2. The droplets are ejected toward designated sites on a substrate surface for deposition thereon. In one embodiment, the device is comprised of: a plurality of reservoirs each adapted to contain a fluid; an ejector comprising a means for generating acoustic radiation and a large F-numbered means for focusing the acoustic radiation at a focal point near the fluid surface in each of the reservoirs; and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The invention is useful in a number of contexts, particularly in the preparation of biomolecular arrays.

摘要翻译： 本发明提供一种用于使用具有大于约2的F数的聚焦装置从含有流体的储存器弹出流体液滴的方法和装置。液滴朝向衬底表面上的指定位置喷射以沉积在其上。 在一个实施例中，该装置包括：多个储存器，每个储存器适于容纳流体; 喷射器，其包括用于产生声辐射的装置和用于将声辐射聚焦在每个储存器中的流体表面附近的焦点处的大的F编号装置; 以及用于将喷射器定位成与每个储存器的声耦合关系的装置。 本发明在许多上下文中是有用的，特别是在生物分子阵列的制备中。

公开(公告)号：US5727089A

公开(公告)日：1998-03-10

申请号：US369015

申请日：1995-01-05

申请人： Lawrence A. Ray ,  Richard N. Ellson

发明人： Lawrence A. Ray ,  Richard N. Ellson

IPC分类号： G06Q20/40 ,  G06T9/00 ,  G07C9/00 ,  G07F7/12 ,  H03M7/30 ,  H04N1/41 ,  G06K9/36

CPC分类号： H03M7/3082 ,  G06Q20/40145 ,  G06T9/008 ,  G07C9/00071 ,  G07F7/08 ,  G07F7/12

摘要： The disclosed method for compressing an image to be stored on a transaction card at one of a plurality of quality levels performs the steps of: a. providing a number of compression codebooks each corresponding to a quality level of the to be compressed image data; b. determining the quality level of the compressed image to be stored on the transaction card; c. determining the compression codebook that best corresponds to the determined quality level of step b; and d. compressing the image with the determined compression codebook. A decompression system is disclosed for processing, the transaction cards having the compressed image data stored thereon at one of a plurality of quality levels by, determining the maximum quality level common to the transaction card and the decompression system; and decompressing the compressed image data at the above maximum quality level. At each quality level of compression/decompression that represented image is of equal size.

摘要翻译： 所公开的以多个质量水平中的一个压缩要存储在交易卡上的图像的方法执行以下步骤：a。 提供与压缩图像数据的质量等级对应的多个压缩码本; b。 确定要存储在交易卡上的压缩图像的质量水平; C。 确定与步骤b的所确定的质量水平最佳对应的压缩码本; 和d。 用确定的压缩码本压缩图像。 公开了一种用于处理的解压缩系统，其中以多个质量水平中的一个存储有压缩图像数据的交易卡，确定交易卡和解压缩系统共同的最大质量水平; 并以上述最大质量水平解压缩压缩图像数据。 在表示图像的每个质量级别的压缩/解压缩具有相同的大小。