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1.发明申请NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物公开(公告)号：US20140309412A1
公开(公告)日：2014-10-16
申请号：US13916322
申请日：2013-06-12
申请人： Balkrishen Bhat , Anne B. El drup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
发明人： Balkrishen Bhat , Anne B. El drup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
IPC分类号： C07H17/02
CPC分类号： C07H19/10 , A61K9/4858 , C07D471/04 , C07D473/34 , C07D487/04 , C07H17/02 , C07H19/06 , C07H19/16 , C07H19/207 , Y02P20/582
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。
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2.发明申请Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 有权核苷衍生物作为RNA依赖性RNA病毒聚合酶的抑制剂公开(公告)号：US20120165515A1
公开(公告)日：2012-06-28
申请号：US11701682
申请日：2007-02-02
申请人： Balkrishen Bhat , Anne B. Eldrup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
发明人： Balkrishen Bhat , Anne B. Eldrup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
IPC分类号： C07H19/20
CPC分类号： C07H19/10 , A61K9/4858 , C07D471/04 , C07D473/34 , C07D487/04 , C07H17/02 , C07H19/06 , C07H19/16 , C07H19/207 , Y02P20/582
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。
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公开(公告)号：US08481712B2
公开(公告)日：2013-07-09
申请号：US11701682
申请日：2007-02-02
申请人： Balkrishen Bhat , Anne B. Eldrup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
发明人： Balkrishen Bhat , Anne B. Eldrup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
CPC分类号： C07H19/10 , A61K9/4858 , C07D471/04 , C07D473/34 , C07D487/04 , C07H17/02 , C07H19/06 , C07H19/16 , C07H19/207 , Y02P20/582
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
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公开(公告)号：US07125855B2
公开(公告)日：2006-10-24
申请号：US10688691
申请日：2003-10-17
申请人： Balkrishen Bhat , Neelima Bhat , Anne B. Eldrup , Thazha P. Prakash , Marija Prhavc , Quanlai Song , Phillip Dan Cook , Steven S. Carroll , Malcolm Maccoss , David B. Olsen
发明人： Balkrishen Bhat , Neelima Bhat , Anne B. Eldrup , Thazha P. Prakash , Marija Prhavc , Quanlai Song , Phillip Dan Cook , Steven S. Carroll , Malcolm Maccoss , David B. Olsen
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
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5.发明授权Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 有权核苷衍生物作为RNA依赖性RNA病毒聚合酶的抑制剂公开(公告)号：US07105499B2
公开(公告)日：2006-09-12
申请号：US10250873
申请日：2002-01-18
申请人： Steven S. Carroll , David B. Olsen , Malcolm MacCoss , Balkrishen Bhat , Phillip Dan Cook , Anne B. Eldrup , Thazha P. Prakash
发明人： Steven S. Carroll , David B. Olsen , Malcolm MacCoss , Balkrishen Bhat , Phillip Dan Cook , Anne B. Eldrup , Thazha P. Prakash
IPC分类号： A61K31/7052 , A61K31/7042 , A61K31/7068 , C07H19/04 , C07H19/06
CPC分类号： A61K45/06 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07H19/10 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的药物组合物。 还公开了本发明的核苷衍生物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。
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6.发明授权Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus 有权核苷衍生物作为丙型肝炎病毒RNA依赖性RNA病毒聚合酶的抑制剂公开(公告)号：US06777395B2
公开(公告)日：2004-08-17
申请号：US10052318
申请日：2002-01-18
申请人： Balkrishen Bhat , Neelima Bhat , Anne B. Eldrup , Thazha P. Prakash , Marija Prhavc , Quanlai Song , Phillip Dan Cook , Steven S. Carroll , Malcolm Maccoss , David B. Olsen
发明人： Balkrishen Bhat , Neelima Bhat , Anne B. Eldrup , Thazha P. Prakash , Marija Prhavc , Quanlai Song , Phillip Dan Cook , Steven S. Carroll , Malcolm Maccoss , David B. Olsen
IPC分类号： A61K3170
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。
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公开(公告)号：US06914148B2
公开(公告)日：2005-07-05
申请号：US10247893
申请日：2002-09-20
IPC分类号： C07H21/02 , A61K31/712 , A61K48/00 , A61P35/00 , C07C335/38 , C07F9/24 , C07H21/00 , C07H21/04 , C07F9/02
CPC分类号： C07H21/00
摘要： The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
摘要翻译： 本发明提供了与选定的RNA或DNA序列特异性杂交的寡聚体，其中低聚物的至少一个核苷部分被修饰成包括胍基。 这些低聚物可用于诊断，治疗和调查目的。
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公开(公告)号：US06147200A
公开(公告)日：2000-11-14
申请号：US378568
申请日：1999-08-19
申请人： Muthiah Manoharan , Andrew M. Kawasaki , Phillip Dan Cook , Allister S. Fraser , Thazha P. Prakash
发明人： Muthiah Manoharan , Andrew M. Kawasaki , Phillip Dan Cook , Allister S. Fraser , Thazha P. Prakash
IPC分类号： C12N15/09 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/712 , A61K38/00 , A61K48/00 , A61P43/00 , C07H19/04 , C07H19/067 , C07H19/10 , C07H19/167 , C07H19/20 , C07H21/00 , C07H21/02
摘要： Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to have increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
摘要翻译： 提供了由其制备的核苷单体和寡聚化合物。 还提供了低聚化合物的脱保护的新方法。 具有至少一个2'-O-乙酰氨基修饰的核糖单体的低聚化合物预期具有增加的核酸酶抗性和与核酸互补链的结合亲和力。 这样的低聚化合物可用于诊断和其他研究目的，用于调节生物体中的蛋白质的表达，以及用于诊断，检测和治疗对寡核苷酸治疗剂有反应的其它病症。
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公开(公告)号：US06593466B1
公开(公告)日：2003-07-15
申请号：US09349040
申请日：1999-07-07
IPC分类号： C07H1904
CPC分类号： C07H21/00
摘要： The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
摘要翻译： 本发明提供了与选定的RNA或DNA序列特异性杂交的寡聚体，其中低聚物的至少一个核苷部分被修饰成包括胍基。 这些低聚物可用于诊断，治疗和调查目的。
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公开(公告)号：US06534639B1
公开(公告)日：2003-03-18
申请号：US09612531
申请日：2000-07-07
IPC分类号： C07H2100
CPC分类号： C07H21/00
摘要： The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
摘要翻译： 本发明提供了与选定的RNA或DNA序列特异性杂交的寡聚体，其中低聚物的至少一个核苷部分被修饰成包括胍基。 这些低聚物可用于诊断，治疗和调查目的。
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