公开(公告)号：US11344600B2

公开(公告)日：2022-05-31

申请号：US16335349

申请日：2017-10-05

Applicant: Baylor College of Medicine

Inventor： B. Venkataram Prasad ,  Mary K. Estes ,  Yongcheng Song

IPC: A61K38/06 ,  A61K31/27 ,  A61K31/40 ,  A61K31/407 ,  A61K38/00 ,  A61K45/06 ,  A61P31/14 ,  G16C20/50 ,  G16B15/30 ,  A01N47/12 ,  C07K5/068 ,  C07K5/062 ,  C07D295/10 ,  A01N47/28 ,  A01N47/34 ,  C07C201/00 ,  C07C271/18 ,  C07D498/08 ,  A61K9/00 ,  A01N43/90 ,  C07C271/22 ,  A61K31/395 ,  A01N43/64 ,  A01N37/46

Abstract: The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

公开(公告)号：US20150065466A1

公开(公告)日：2015-03-05

申请号：US14390736

申请日：2013-04-18

Applicant: Baylor College of Medicine

Inventor： Yongcheng Song

IPC: C07F9/58 ,  C07F9/6521 ,  A61K45/06 ,  C07F9/6506 ,  A61K31/675 ,  A61K31/662 ,  C07F9/6512 ,  C07F9/38

CPC classification number: C07F9/58 ,  A61K31/662 ,  A61K31/675 ,  A61K45/06 ,  C07F9/3808 ,  C07F9/6506 ,  C07F9/6512 ,  C07F9/6521 ,  Y02A50/411

Abstract: The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target DXR. In some cases, the antimicrobial agent comprises an electron-deficient hydrophobic group that has interacts with Trp211 of DXR. In specific embodiments, the compound contains electron-deficient heterocyclic rings that specifically interact with the electron-rich indole ring of Trp211. In certain aspects, the compositions comprise a phosphate group, a pyridine group, and a hydroxymate group.

Abstract translation: 本发明一般涉及抗微生物治疗的具体方法和组合物。 在具体实施方案中，组合物靶向DXR。 在一些情况下，抗微生物剂包含与DXR的Trp211相互作用的电子缺陷型疏水基团。 在具体实施方案中，化合物含有与Trp211的富电子的吲哚环特异性相互作用的电子缺乏的杂环。 在某些方面，组合物包含磷酸基，吡啶基和羟基伴侣基。

公开(公告)号：US11312676B2

公开(公告)日：2022-04-26

申请号：US15540386

申请日：2015-12-29

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： David Michael Lonard ,  Lei Wang ,  Bert W. O'Malley ,  Jianming Xu ,  Yongcheng Song ,  Xiaonan Li ,  Timothy Gerald Palzkill

IPC: C07C49/753 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4402 ,  A61K31/351 ,  A61K31/4433 ,  A61K31/122 ,  A61K31/4545 ,  C07D401/06 ,  C07D309/38 ,  C07D405/06 ,  C07D213/68 ,  C07D405/12 ,  A61P35/00 ,  C07C49/697 ,  C07D211/86 ,  C07D213/50 ,  C07D309/32 ,  C07D401/14 ,  C07D405/14

Abstract: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.

公开(公告)号：US20200071300A1

公开(公告)日：2020-03-05

申请号：US16554733

申请日：2019-08-29

Applicant: Baylor College of Medicine

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Yongcheng Song

IPC: C07D401/14 ,  C07D401/08 ,  A61P9/10

Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

公开(公告)号：US20190275101A1

公开(公告)日：2019-09-12

申请号：US16335349

申请日：2017-10-05

Applicant: Baylor College of Medicine

Inventor： B. Venkataram Prasad ,  Mary K. Estes ,  Yongcheng Song

IPC: A61K38/06 ,  G16B15/30 ,  G16C20/50 ,  A01N47/12 ,  A61K45/06 ,  A61P31/14

Abstract: The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

公开(公告)号：US11708350B2

公开(公告)日：2023-07-25

申请号：US17030924

申请日：2020-09-24

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Yongcheng Song

IPC: C07D401/14 ,  A61P9/10 ,  C07D401/08

CPC classification number: C07D401/14 ,  A61P9/10 ,  C07D401/08

Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

公开(公告)号：US20210115017A1

公开(公告)日：2021-04-22

申请号：US17030924

申请日：2020-09-24

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Yongcheng Song

IPC: C07D401/14 ,  C07D401/08 ,  A61P9/10

Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

公开(公告)号：US20230357200A1

公开(公告)日：2023-11-09

申请号：US18205630

申请日：2023-06-05

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Yongcheng Song

IPC: C07D401/14 ,  A61P9/10 ,  C07D401/08

CPC classification number: C07D401/14 ,  A61P9/10 ,  C07D401/08

Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

公开(公告)号：US20230167101A1

公开(公告)日：2023-06-01

申请号：US17918074

申请日：2021-04-08

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Yongcheng Song ,  Fangrui Wu ,  Shenyou Nie ,  Yuanda Hua ,  Yi-Lun Lin ,  Salma Kaochar ,  Nicholas Mitsiades

IPC: C07D409/12 ,  A61P35/00 ,  C07D405/14 ,  C07D409/14 ,  C07D333/20 ,  C07D405/12 ,  C07D417/12

CPC classification number: C07D409/12 ,  A61P35/00 ,  C07D333/20 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12

Abstract: Embodiments of the present disclosure pertain to compositions that include a compound that inhibits the histone acetyl transferase activity of a protein, such as p300 and/or CBP. Further embodiments of the present disclosure pertain to methods of inhibiting the histone acetyl transferase activity of a protein by exposing the protein to a composition that contains one or more of the compounds of the present disclosure. The compositions of the present disclosure may be exposed to a protein in vitro or in vivo. Additional embodiments of the present disclosure pertain to methods of treating a cancer in a subject by administering a composition of the present disclosure to the subject in order to treat the cancer.

公开(公告)号：US20180265444A1

公开(公告)日：2018-09-20

申请号：US15540386

申请日：2015-12-29

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： David Michael Lonard ,  Lei Wang ,  Bert W. O'Malley ,  Jianming Xu ,  Yongcheng Song ,  Xiaonan Li ,  Timothy Gerald Palzkill

IPC: C07C49/753 ,  A61P35/00 ,  C07C49/697 ,  C07D213/50 ,  C07D309/32 ,  C07D405/14 ,  C07D211/86 ,  C07D401/14

CPC classification number: C07C49/753 ,  A61K31/122 ,  A61K31/351 ,  A61K31/4402 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4545 ,  A61P35/00 ,  C07C49/697 ,  C07C2601/14 ,  C07D211/86 ,  C07D213/50 ,  C07D213/68 ,  C07D309/32 ,  C07D309/38 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

Abstract: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.