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公开(公告)号：US10697010B2
公开(公告)日：2020-06-30
申请号：US15046225
申请日：2016-02-17
Applicant: Becton, Dickinson and Company
Inventor： Clark Mason , Liping Yu
IPC: C12Q1/6874 , C12Q1/6806 , G01N15/14 , C12Q1/6804 , C12Q1/6886 , G01N15/10
Abstract: Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells. Obtaining sequence information may include generating a molecularly indexed polynucleotide library from the one or more isolated cells. Enriching the sample may include focusing cells of interest in the sample using acoustic focusing.
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公开(公告)号：US20160252445A1
公开(公告)日：2016-09-01
申请号：US15154810
申请日：2016-05-13
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu , Brian David Warner , Joseph T. Trotter
CPC classification number: G01N15/1404 , B01L3/502761 , B01L2200/0652 , B01L2300/0877 , B01L2400/043 , B01L2400/0439 , B03C1/02 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N1/4077 , G01N15/02 , G01N15/1056 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/54326 , G01N2001/4038 , G01N2001/4094 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/142 , G01N2015/149
Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.
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公开(公告)号：US20150160116A1
公开(公告)日：2015-06-11
申请号：US14590659
申请日：2015-01-06
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu , Brian David Warner , Joseph T. Trotter
IPC: G01N15/14
CPC classification number: G01N15/1404 , B01L3/502761 , B01L2200/0652 , B01L2300/0877 , B01L2400/043 , B01L2400/0439 , B03C1/02 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N1/4077 , G01N15/02 , G01N15/1056 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/54326 , G01N2001/4038 , G01N2001/4094 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/142 , G01N2015/149
Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.
Abstract translation: 提供用于分选液体样品中包含的组分（例如，细胞）的装置。 在某些方面，这些装置包括磁分离装置和流体耦合到磁分离装置的声聚集装置。 本发明的方面还包括用于分选液体样品中的细胞的方法，以及用于实践本发明方法的系统和试剂盒。
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公开(公告)号：US20140120570A1
公开(公告)日：2014-05-01
申请号：US14061678
申请日：2013-10-23
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu , Brian David Warner , Joseph T. Trotter
IPC: G01N33/543 , G01N1/34
CPC classification number: G01N15/1404 , B01L3/502761 , B01L2200/0652 , B01L2300/0877 , B01L2400/043 , B01L2400/0439 , B03C1/02 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N1/4077 , G01N15/02 , G01N15/1056 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/54326 , G01N2001/4038 , G01N2001/4094 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/142 , G01N2015/149
Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.
Abstract translation: 提供用于分选液体样品中包含的组分（例如，细胞）的装置。 在某些方面，这些装置包括磁分离装置和流体耦合到磁分离装置的声聚集装置。 本发明的方面还包括用于分选液体样品中的细胞的方法，以及用于实践本发明方法的系统和试剂盒。
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公开(公告)号：US11098358B2
公开(公告)日：2021-08-24
申请号：US16863280
申请日：2020-04-30
Applicant: Becton, Dickinson and Company
Inventor： Clark Mason , Liping Yu
IPC: C12Q1/6874 , C12Q1/6806 , G01N15/14 , C12Q1/6804 , C12Q1/6886 , G01N15/10
Abstract: Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells. Obtaining sequence information may include generating a molecularly indexed polynucleotide library from the one or more isolated cells. Enriching the sample may include focusing cells of interest in the sample using acoustic focusing.
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Patent Agency Ranking
公开(公告)号：US20180136098A1
公开(公告)日：2018-05-17
申请号：US15854455
申请日：2017-12-26
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu
CPC classification number: G01N1/34 , B03C1/0332 , B03C1/035 , B03C2201/18 , B03C2201/26
Abstract: Devices for separating magnetically labeled moieties in a sample are provided. Aspects of the devices include a magnetic field source, a first magnetic field guide having a wedge-shaped portion with an apex edge, and a second magnetic field guide having a wedge-shaped portion with an apex edge. The apex edge of the first magnetic field guide is aligned substantially across from and parallel to the apex edge of the second magnetic field guide, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. Also provided are methods of using the devices, as well as systems and kits configured for use with the devices and methods.
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公开(公告)号：US09835540B2
公开(公告)日：2017-12-05
申请号：US15154810
申请日：2016-05-13
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu , Brian David Warner , Joseph T. Trotter
IPC: G01N33/487 , G01N15/14 , G01N1/34 , G01N33/543 , B03C1/28 , G01N15/02 , B01L3/00 , G01N1/40 , B03C1/02 , G01N15/10 , G01N15/00
CPC classification number: G01N15/1404 , B01L3/502761 , B01L2200/0652 , B01L2300/0877 , B01L2400/043 , B01L2400/0439 , B03C1/02 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N1/4077 , G01N15/02 , G01N15/1056 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/54326 , G01N2001/4038 , G01N2001/4094 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/142 , G01N2015/149
Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.
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公开(公告)号：US20210395817A1
公开(公告)日：2021-12-23
申请号：US17375377
申请日：2021-07-14
Applicant: Becton, Dickinson and Company
Inventor： Clark Mason , Liping Yu
IPC: C12Q1/6874 , C12Q1/6806 , G01N15/14 , C12Q1/6804 , C12Q1/6886
Abstract: Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells. Obtaining sequence information may include generating a molecularly indexed polynucleotide library from the one or more isolated cells. Enriching the sample may include focusing cells of interest in the sample using acoustic focusing.
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公开(公告)号：US20200308642A1
公开(公告)日：2020-10-01
申请号：US16863280
申请日：2020-04-30
Applicant: Becton, Dickinson and Company
Inventor： Clark Mason , Liping Yu
IPC: C12Q1/6874 , C12Q1/6806 , G01N15/14 , C12Q1/6804 , C12Q1/6886
Abstract: Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells. Obtaining sequence information may include generating a molecularly indexed polynucleotide library from the one or more isolated cells. Enriching the sample may include focusing cells of interest in the sample using acoustic focusing.
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公开(公告)号：US20170363522A1
公开(公告)日：2017-12-21
申请号：US15611651
申请日：2017-06-01
Applicant: Becton, Dickinson and Company
Inventor： Liping Yu
CPC classification number: G01N1/4077 , B01L3/502 , B01L3/502707 , B01L3/502761 , B01L2200/0652 , B01L2300/0887 , B01L2400/0436 , G01N15/1404 , G01N15/1459 , G01N2001/4094 , G01N2015/1006 , G01N2015/142 , G01N2015/149
Abstract: Aspects of the present disclosure include an acoustic separator for acoustically separating components of a sample, such as a biological sample. Acoustic separators according to certain embodiments include an acoustic field generator soldered to a flow channel having a fluid flow path where the acoustic field generator produces an acoustic field in the fluid flow path. Methods of soldering an acoustic field generator to a flow channel having a fluid flow path are also described. Methods for acoustically separating components of a sample as well as systems and kits, including one or more acoustic separators, suitable for practicing the subject methods are also provided.
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