Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
    4.
    发明申请
    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus 失效
    使用内过氧化物治疗由黄病毒引起的感染,包括丙型肝炎,牛病毒性腹泻和古典猪瘟病毒

    公开(公告)号:US20050059647A1

    公开(公告)日:2005-03-17

    申请号:US10664008

    申请日:2003-09-16

    摘要: The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specificly have efficacy as treatments for hepatitis C viral infections.

    摘要翻译: 使用倍半萜烯,特别是倍半萜内酯内过氧化物,如青蒿素及其类似物,用于治疗丙型肝炎病毒感染。 在体外对DNA病毒,逆转录病毒和黄病毒(人类和动物RNA病原体的重要家族)进行体外测定青蒿素,青蒿素类似物和一些粗蒿提取物。 也筛选了这些化合物的抗肿瘤活性。 注意到青蒿素对牛病毒性腹泻病毒(BVDV)的活性较强。 由于瘟病毒,如BVDV,与丙型肝炎病毒(HCV)有很多相似之处,我们可以得出结论,一般的过氧化物和青蒿素更具体地具有作为丙型肝炎病毒感染治疗的功效。

    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
    7.
    发明授权
    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus 失效
    使用内过氧化物治疗由黄病毒引起的感染,包括丙型肝炎,牛病毒性腹泻和古典猪瘟病毒

    公开(公告)号:US07842719B2

    公开(公告)日:2010-11-30

    申请号:US10664008

    申请日:2003-09-16

    IPC分类号: A61K31/335 A61K38/00

    摘要: The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specifically have efficacy as treatments for hepatitis C viral infections.

    摘要翻译: 使用倍半萜烯,特别是倍半萜内酯内过氧化物,如青蒿素及其类似物,用于治疗丙型肝炎病毒感染。 在体外对DNA病毒,逆转录病毒和黄病毒(人类和动物RNA病原体的重要家族)进行体外测定青蒿素,青蒿素类似物和一些粗蒿提取物。 也筛选了这些化合物的抗肿瘤活性。 注意到青蒿素对牛病毒性腹泻病毒(BVDV)的活性较强。 作为瘟病毒,如BVDV,与丙型肝炎病毒(HCV)有许多相似之处,我们可以得出结论,一般的过氧化物和青蒿素更具体地具有治疗丙型肝炎病毒感染的功效。