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    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
    1.
    发明申请
    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus 失效
    使用内过氧化物治疗由黄病毒引起的感染，包括丙型肝炎，牛病毒性腹泻和古典猪瘟病毒

    公开(公告)号：US20050059647A1

    公开(公告)日：2005-03-17

    申请号：US10664008

    申请日：2003-09-16

    申请人： Benedikt Sas ,  Johan hemel ,  Jan Vandenkerckhove ,  Eric Peys

    发明人： Benedikt Sas ,  Johan hemel ,  Jan Vandenkerckhove ,  Eric Peys

    IPC分类号： A61K31/335 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61K36/282 ,  A61K38/21 ,  A61K45/06

    CPC分类号： A61K31/55 ,  A61K31/335 ,  A61K31/553 ,  A61K31/554 ,  A61K36/282 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

    摘要： The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specificly have efficacy as treatments for hepatitis C viral infections.

    摘要翻译： 使用倍半萜烯，特别是倍半萜内酯内过氧化物，如青蒿素及其类似物，用于治疗丙型肝炎病毒感染。 在体外对DNA病毒，逆转录病毒和黄病毒（人类和动物RNA病原体的重要家族）进行体外测定青蒿素，青蒿素类似物和一些粗蒿提取物。 也筛选了这些化合物的抗肿瘤活性。 注意到青蒿素对牛病毒性腹泻病毒（BVDV）的活性较强。 由于瘟病毒，如BVDV，与丙型肝炎病毒（HCV）有很多相似之处，我们可以得出结论，一般的过氧化物和青蒿素更具体地具有作为丙型肝炎病毒感染治疗的功效。

    Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites
    8.
    发明授权
    Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites 失效
    双环碳水化合物作为抗原生物活性物质用于治疗由寄生虫引起的感染

    公开(公告)号：US07125854B2

    公开(公告)日：2006-10-24

    申请号：US10752792

    申请日：2004-01-07

    申请人： Benedikt Sas ,  Johan Van hemel ,  Jan Vandenkerckhove ,  Eric Peys ,  Johan Van der Eycken ,  Bart Ruttens

    发明人： Benedikt Sas ,  Johan Van hemel ,  Jan Vandenkerckhove ,  Eric Peys ,  Johan Van der Eycken ,  Bart Ruttens

    IPC分类号： A01N43/04 ,  A01N43/16 ,  A61K31/70 ,  A61K31/35

    CPC分类号： C07D493/04

    摘要： The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tumors, bacteria and fungi. Compound A1, a thiophenyl-containing bicyclic carbohydrate possessed significant activity against Trypanosoma brucei rhodiense, a parasite that causes the lethal sleeping sickness. Compound A2 and Compound A3, bicyclic carbohydrates with halogen containing aryl groups, possessed significant activity against Leishmania donovani, a parasite that causes leishmaniasis. Bicyclic carbohydrates in general, and Compound A1, Compound A2 and Compound A3 more specifically, could be possible treatments for the sleeping sickness and leishmaniasis in the future.

    摘要翻译： 描述了使用双环碳水化合物治疗寄生虫感染。 已经在体外对许多原生动物测试了不同的双环碳水化合物。 这些化合物也已经针对病毒，肿瘤，细菌和真菌进行了筛选。 化合物A1，含噻吩基的双环碳水化合物对引起致死性昏睡病的寄生虫Brucei rhodiense具有显着的活性。 化合物A2和化合物A3，具有含卤素芳基的双环碳水化合物，对引起利什曼病的寄生虫的利什曼原虫（Leishmania donovani）具有显着的活性。 一般来说，双环碳水化合物，化合物A1，化合物A2和化合物A3更具体地可能是今后睡眠病和利什曼病的治疗方法。

    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
    10.
    发明授权
    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus 失效
    使用内过氧化物治疗由黄病毒引起的感染，包括丙型肝炎，牛病毒性腹泻和古典猪瘟病毒

    公开(公告)号：US07842719B2

    公开(公告)日：2010-11-30

    申请号：US10664008

    申请日：2003-09-16

    申请人： Benedikt Sas ,  Johan Van hemel ,  Jan Vandenkerckhove ,  Eric Peys ,  Johan Neyts

    发明人： Benedikt Sas ,  Johan Van hemel ,  Jan Vandenkerckhove ,  Eric Peys ,  Johan Neyts

    IPC分类号： A61K31/335 ,  A61K38/00

    CPC分类号： A61K31/55 ,  A61K31/335 ,  A61K31/553 ,  A61K31/554 ,  A61K36/282 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

    摘要： The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specifically have efficacy as treatments for hepatitis C viral infections.

    摘要翻译： 使用倍半萜烯，特别是倍半萜内酯内过氧化物，如青蒿素及其类似物，用于治疗丙型肝炎病毒感染。 在体外对DNA病毒，逆转录病毒和黄病毒（人类和动物RNA病原体的重要家族）进行体外测定青蒿素，青蒿素类似物和一些粗蒿提取物。 也筛选了这些化合物的抗肿瘤活性。 注意到青蒿素对牛病毒性腹泻病毒（BVDV）的活性较强。 作为瘟病毒，如BVDV，与丙型肝炎病毒（HCV）有许多相似之处，我们可以得出结论，一般的过氧化物和青蒿素更具体地具有治疗丙型肝炎病毒感染的功效。