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公开(公告)号：US20090124832A1
公开(公告)日：2009-05-14
申请号：US12357323
申请日：2009-01-21
申请人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
发明人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
IPC分类号： C07C237/06
CPC分类号： C07C215/18 , C07C211/14
摘要： Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
摘要翻译： 提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用该化合物的方法。 该化合物显示出对前列腺癌细胞系和抗小鼠前列腺癌肿瘤的活性。 该化合物也可用于治疗乳腺癌和其它癌症。
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公开(公告)号：US07026347B2
公开(公告)日：2006-04-11
申请号：US10606016
申请日：2003-06-24
申请人： Benjamin Frydman , Aldonia L. Valasinas , Venodhar K. Reddy , Hirak S. Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence J. Marton , Andrei V. Blokhin
发明人： Benjamin Frydman , Aldonia L. Valasinas , Venodhar K. Reddy , Hirak S. Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence J. Marton , Andrei V. Blokhin
IPC分类号： A61K31/40 , A61K31/555 , A61B5/055 , A61B10/00 , C07B47/00
CPC分类号： C07D487/22
摘要： Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.
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公开(公告)号：US06982351B2
公开(公告)日：2006-01-03
申请号：US10313530
申请日：2002-12-06
申请人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
发明人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
IPC分类号： C07C211/17
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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公开(公告)号：US07235695B2
公开(公告)日：2007-06-26
申请号：US11205341
申请日：2005-08-16
申请人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
发明人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
IPC分类号： C07C209/24 , C07C209/28 , C07C211/17
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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公开(公告)号：US07186825B2
公开(公告)日：2007-03-06
申请号：US10873100
申请日：2004-06-21
申请人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu
发明人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu
IPC分类号： C07C47/00
CPC分类号： C07C211/09 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/18 , C07C211/22 , C07C211/23 , C07C211/36 , C07C215/14 , C07C257/18 , C07C2601/04 , C07C2601/08 , C07D207/34 , C07D219/10 , C07D235/18 , C07D295/185 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D487/22 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
摘要翻译： 提供新颖的构象限制性多胺类似物，以及包含这些新型多胺类似物的组合物。 还提供了将新型多胺类似物用于治疗诸如癌症的疾病的方法。 还提供了通过将多胺类似物共价连接到卟啉化合物以及新型多胺 - 卟啉共价缀合物将这些类似物特异性递送至肿瘤细胞的方法。
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公开(公告)号：US06794545B1
公开(公告)日：2004-09-21
申请号：US09560711
申请日：2000-04-27
申请人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia Valasinas , Andrei V. Blokhin , Hirak S. Basu
发明人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia Valasinas , Andrei V. Blokhin , Hirak S. Basu
IPC分类号： C07C21113
CPC分类号： C07C211/09 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/18 , C07C211/22 , C07C211/23 , C07C211/36 , C07C215/14 , C07C257/18 , C07C2601/04 , C07C2601/08 , C07D207/34 , C07D219/10 , C07D235/18 , C07D295/185 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D487/22 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to, porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
摘要翻译： 提供新颖的构象限制性多胺类似物，以及包含这些新型多胺类似物的组合物。 还提供了将新型多胺类似物用于治疗诸如癌症的疾病的方法。 还提供了通过将多胺类似物与新的多胺 - 卟啉共价缀合物共价连接到卟啉化合物，将这些类似物特异性递送到肿瘤细胞的方法。
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公开(公告)号：US07253207B2
公开(公告)日：2007-08-07
申请号：US10909978
申请日：2004-08-02
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： A61K31/35 , C07D311/92
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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公开(公告)号：US06809176B2
公开(公告)日：2004-10-26
申请号：US10139978
申请日：2002-05-06
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： C07K200
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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公开(公告)号：US06482943B1
公开(公告)日：2002-11-19
申请号：US09562980
申请日：2000-04-27
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： C07B4700
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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公开(公告)号：US08501930B2
公开(公告)日：2013-08-06
申请号：US13326433
申请日：2011-12-15
申请人： David B. Rozema , Darren H. Wakefield , David L. Lewis , Jon A. Wolff , Andrei V. Blokhin , Jonathan D. Benson , Jeffrey C. Carlson , Philipp Hadwiger , Eric A. Kitas , Torsten Hoffmann , Kerstin Jahn-Hofmann , Peter Mohr , Hans Martin Mueller , Guenther Ott , Ingo Roehl
发明人： David B. Rozema , Darren H. Wakefield , David L. Lewis , Jon A. Wolff , Andrei V. Blokhin , Jonathan D. Benson , Jeffrey C. Carlson , Philipp Hadwiger , Eric A. Kitas , Torsten Hoffmann , Kerstin Jahn-Hofmann , Peter Mohr , Hans Martin Mueller , Guenther Ott , Ingo Roehl
CPC分类号： A61K47/48261 , A61K47/549 , A61K47/64 , A61K47/6415 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
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