公开(公告)号：US20200064337A1

公开(公告)日：2020-02-27

申请号：US16391063

申请日：2019-04-22

Applicant: Berkeley Lights, Inc.

Inventor： Minha Park ,  Jason C. Briggs ,  Jason M. McEwen ,  Ravi K. Ramenani ,  Hariharasudhan Chirra Dinakar ,  Kai W. Szeto ,  Adrienne T. Higa ,  Mark P. White ,  Randall D. Lowe, JR. ,  Xiaohua Wang ,  Kevin T. Chapman

IPC: G01N33/50 ,  B01L3/00 ,  C12N5/0781 ,  G01N33/68 ,  C12Q1/6876

Abstract: Methods are described herein for screening an antibody producing cell within a microfluidic environment. The antibody producing cell may be a B cell lymphocyte, which may be a memory B cell or a plasma cell. An antigen of interest may be brought into proximity with the antibody producing cell and binding of the antigen by an antibody produced by the antibody producing cell may be monitored. Methods of obtaining a sequencing library from an antibody producing cell are also described.

公开(公告)号：US10829728B2

公开(公告)日：2020-11-10

申请号：US16010176

申请日：2018-06-15

Applicant: Berkeley Lights, Inc.

Inventor： Volker L. S. Kurz ,  Troy A. Lionberger ,  Eric K. Sackmann ,  Kai W. Szeto ,  Paul M. Lebel ,  Brandon R. Bruhn ,  Keith J. Breinlinger ,  Eric D. Hobbs ,  Andrew W. McFarland ,  J. Tanner Nevill ,  Xiaohua Wang

IPC: B01L3/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/26

Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.

公开(公告)号：US11802264B2

公开(公告)日：2023-10-31

申请号：US17067971

申请日：2020-10-12

Applicant: Berkeley Lights, Inc.

Inventor： Volker L. S. Kurz ,  Troy A. Lionberger ,  Eric K. Sackmann ,  Kai W. Szeto ,  Paul M. Lebel ,  Brandon R. Bruhn ,  Keith J. Breinlinger ,  Eric D. Hobbs ,  Andrew W. McFarland ,  J. Tanner Nevill ,  Xiaohua Wang

IPC: B01L3/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/26 ,  G01N15/14

CPC classification number: C12M23/16 ,  B01L3/502761 ,  C12M23/20 ,  C12M33/12 ,  B01L2200/0668 ,  B01L2300/1822 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0442 ,  B01L2400/0454 ,  B01L2400/086

Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.

公开(公告)号：US20210102150A1

公开(公告)日：2021-04-08

申请号：US17067971

申请日：2020-10-12

Applicant: Berkeley Lights, Inc.

Inventor： Volker L.S. Kurz ,  Troy A. Lionberger ,  Eric K. Sackmann ,  Kai W. Szeto ,  Paul M. Lebel ,  Brandon R. Bruhn ,  Keith J. Breinlinger ,  Eric D. Hobbs ,  Andrew W. McFarland ,  J. Tanner Nevill ,  Xiaohua Wang

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/26

Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.

公开(公告)号：US20180298318A1

公开(公告)日：2018-10-18

申请号：US16010176

申请日：2018-06-15

Applicant: Berkeley Lights, Inc.

Inventor： Volker L.S. Kurz ,  Troy A. Lionberger ,  Erik K. Sackmann ,  Kai W. Szeto ,  Paul M. Lebel ,  Brandon R. Bruhn ,  Keith J. Breinlinger ,  Eric D. Hobbs ,  Andrew W. McFarland ,  J. Tanner Nevill ,  Xiaohua Wang

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/26

CPC classification number: C12M23/16 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/1822 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0442 ,  B01L2400/0454 ,  B01L2400/086 ,  C12M23/20 ,  C12M33/12

Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.