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    Stimulated emission depletion (STED) microscopy system
    1.
    发明授权
    Stimulated emission depletion (STED) microscopy system 有权

    公开(公告)号：US10725275B2

    公开(公告)日：2020-07-28

    申请号：US13522038

    申请日：2011-01-13

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    IPC分类号： G02B21/00 ,  G01N21/64

    摘要： The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.

    STIMULATED EMISSION DEPLETION (STED) MICROSCOPY SYSTEM
    2.
    发明申请
    STIMULATED EMISSION DEPLETION (STED) MICROSCOPY SYSTEM 审中-公开
    刺激排泄（STED）微观系统

    公开(公告)号：US20140145093A1

    公开(公告)日：2014-05-29

    申请号：US13522038

    申请日：2011-01-13

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    IPC分类号： G02B21/00 ,  G01N21/64

    摘要： The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.

    摘要翻译： 本发明公开了一种用于对象（O）的受激发射耗尽（STED）的光学显微镜系统（10）。 应用光学元件（6）用于将第一激励（1）和第二耗尽（2）光束聚焦在物体上，从而为第一和第二光束定义公共光路（OP）。 相位调整构件（5）被插入到公共光路（OP）中，并且相位修改构件被光学地布置成使第一光束的波前基本上不变，并且用于改变第二光束（2'）的波前， 以便在对象中创建未被删除的兴趣区域（ROI）。 第一光束和第二光束具有共同的光路，因为相位修改构件以这样的方式适配波前或相位，使得其对第一光束没有影响，而在第二光束上，其产生波前或相位 改变，导致焦平面上的物体（例如，环形斑点）中的耗尽区域。 本发明有助于STED显微镜的更小和/或改进的光学设计; 这对于医学体内成像尤其重要，例如， 内窥镜和导管。

    Pulse splitter with dispersion compensation
    3.
    发明授权
    Pulse splitter with dispersion compensation 有权
    具有色散补偿的脉冲分路器

    公开(公告)号：US08941048B2

    公开(公告)日：2015-01-27

    申请号：US13395899

    申请日：2010-09-15

    申请人： Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    发明人： Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    IPC分类号： H01J3/14 ,  G02B27/14 ,  G02B27/10 ,  G02B27/12 ,  H01S3/00

    CPC分类号： G02B27/144 ,  G02B27/106 ,  G02B27/126 ,  H01S3/0057

    摘要： The present invention relates to a pulse splitting device (5) adapted to receive irradiation pulses (10) with a central wavelength (1) from a pulsed irradiation source (2) and output a plurality of sub-pulses (11,12,15,17) for each incoming irradiation pulse. The received irradiation pulses and the pulse splitter (5) interacts so that a first and a second sub-pulse (11,12) are temporally separated by a first optical path length (OP1) in a first region and a second optical path length (OP2) in a second region, respectively. The first optical path length (OP1) times the group velocity dispersion (GVD1) with respect to wavelength in the first material, is balanced with the second optical path length (OP2) times the group velocity dispersion (GVD2) with respect to wavelength in the second material, so that the dispersion broadening of the first and the second sub-pulses (11,12) is substantially equal. This facilitates improved subsequent dispersion compensation by both sub-pulses.

    摘要翻译： 本发明涉及一种适于从脉冲辐射源（2）接收具有中心波长（1）的照射脉冲（10）并输出多个子脉冲（11,12,15， 17）。 所接收的照射脉冲和脉冲分离器（5）相互作用，使得第一和第二子脉冲（11,12）在第一区域和第二光程长度（ OP2）分别在第二区域。 相对于第一材料中的波长的第一光程长度（OP1）乘以群速度色散（GVD1），与第二光程长度（OP2）相比，相对于波长的第二光程长度（OP2）乘以群速度色散（GVD2） 第二材料，使得第一和第二子脉冲（11,12）的色散扩展基本相等。 这有助于通过两个子脉冲改进随后的色散补偿。

    PULSE SPLITTER WITH DISPERSION COMPENSATION
    4.
    发明申请
    PULSE SPLITTER WITH DISPERSION COMPENSATION 有权
    脉冲分配器与分散补偿

    公开(公告)号：US20120168614A1

    公开(公告)日：2012-07-05

    申请号：US13395899

    申请日：2010-09-15

    申请人： Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    发明人： Gert 'T Hooft ,  Jeroen Jan Lambertus Horikx

    IPC分类号： G02B27/12 ,  G01J1/04

    CPC分类号： G02B27/144 ,  G02B27/106 ,  G02B27/126 ,  H01S3/0057

    摘要： The present invention relates to a pulse splitting device (5) adapted to receive irradiation pulses (10) with a central wavelength (1) from a pulsed irradiation source (2) and output a plurality of sub-pulses (11,12, 15,17) for each incoming irradiation pulse. The received irradiation pulses and the pulse splitter (5) interacts so that a first and a second sub-pulse (11,12) are temporally separated by a first optical path length (OP1) in a first region and a second optical path length (OP2) in a second region, respectively. The first optical path length (OP1) times the group velocity dispersion (GVD1) with respect to wavelength in the first material, is balanced with the second optical path length (OP2) times the group velocity dispersion (GVD2) with respect to wavelength in the second material, so that the dispersion broadening of the first and the second sub-pulses (11,12) is substantially equal. This facilitates improved subsequent dispersion compensation by both sub-pulses.

    摘要翻译： 本发明涉及一种适于从脉冲辐射源（2）接收具有中心波长（1）的辐射脉冲（10）的脉冲分离装置（5），并输出多个子脉冲（11,12,15， 17）。 所接收的照射脉冲和脉冲分离器（5）相互作用，使得第一和第二子脉冲（11,12）在第一区域和第二光程长度（ OP2）分别在第二区域。 相对于第一材料中的波长的第一光程长度（OP1）乘以群速度色散（GVD1），与第二光程长度（OP2）相比，相对于波长的第二光程长度（OP2）乘以群速度色散（GVD2） 第二材料，使得第一和第二子脉冲（11,12）的色散扩展基本相等。 这有助于通过两个子脉冲改进随后的色散补偿。

    OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM
    5.
    发明申请
    OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM 审中-公开
    光学检查装置适用于至少部分插入涡轮介质

    公开(公告)号：US20110270093A1

    公开(公告)日：2011-11-03

    申请号：US13142485

    申请日：2010-01-18

    申请人： Adrien Emmanuel Desjardins ,  Martinus Bernardus Van Der Mark ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft

    发明人： Adrien Emmanuel Desjardins ,  Martinus Bernardus Van Der Mark ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft

    IPC分类号： A61B6/00 ,  H01L27/00 ,  G01J3/00 ,  H01J5/02 ,  G01J1/42

    CPC分类号： A61B5/0075 ,  A61B5/0062 ,  A61B5/0084 ,  A61B5/6848

    摘要： An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b, . . . , 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).

    摘要翻译： 提供了适于至少部分地插入混浊介质中的光学检查装置（10）。 光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。 在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。 宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。 用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

    OPTICAL PROBE
    6.
    发明申请
    OPTICAL PROBE 审中-公开
    光学探头

    公开(公告)号：US20100282954A1

    公开(公告)日：2010-11-11

    申请号：US12810523

    申请日：2008-12-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

    IPC分类号： G01J1/58 ,  G01J1/00 ,  G02B26/10

    CPC分类号： A61B5/0062 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00183 ,  A61B1/0019 ,  A61B5/0084

    摘要： The present invention relates to an optical probe (1) with an optical guide (2), e.g. an optical fibre, and a lens system (6) rigidly coupled to an end portion (2a) of the optical guide. The probe has a housing (3) with a cavity for the optical guide, the housing having at its distal end a transparent window (4), the window having an insignificant optical power as compared to the optical power of the said lens system (6). Actuation means (8) displaces the 5 lens system so as to enable optical scanning of a region of interest (ROI). The invention is particularly suited for miniature applications e.g. for in-vivo medical application. By attaching the lens system (6) to the optical guide (2) via the mount (7), the field of view (FOV) of the optical probe (1) may be determined directly by the transverse stroke of the optical fibre (2). Hence only a relatively small stroke is required. The field of view is thus 10 effectively no longer limited by the transverse stroke. The optical probe is especially advantageous for non-linear optical imaging where the optical guide may be an optical fibre with a relatively low exit numerical aperture.

    摘要翻译： 本发明涉及一种具有光导（2）的光学探针（1），例如， 光纤，以及刚性地耦合到光导的端部（2a）的透镜系统（6）。 该探针具有一个具有用于光导的空腔的壳体（3），该壳体在其远端处具有透明窗口（4），该窗口与所述透镜系统（6）的光焦度相比具有无效的光焦度 ）。 驱动装置（8）使5透镜系统移位，以便对感兴趣区域（ROI）进行光学扫描。 本发明特别适用于微型应用，例如 用于体内医疗应用。 通过经由安装件（7）将透镜系统（6）附接到光导（2），光学探头（1）的视场（FOV）可以直接由光纤（2）的横向行程确定 ）。 因此，只需要相对较小的行程。 因此，视场10不再受横向行程的限制。 光学探头对于非线性光学成像特别有利，其中光导可以是具有相对低的出射数值孔径的光纤。

    Method and device for imaging an interior of a turbid medium using an amplification factor selected from an estimate of expected electrical signal strength
    9.
    发明授权
    Method and device for imaging an interior of a turbid medium using an amplification factor selected from an estimate of expected electrical signal strength 有权
    用于使用从预期电信号强度的估计中选择的放大因子对混浊介质的内部进行成像的方法和装置

    公开(公告)号：US07750331B2

    公开(公告)日：2010-07-06

    申请号：US12094634

    申请日：2006-11-21

    申请人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

    发明人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

    IPC分类号： G01N15/06 ,  G01N21/49 ,  G01N21/85

    CPC分类号： A61B5/4312 ,  A61B5/0091

    摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.

    摘要翻译： 本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。 从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个 检测位置（25b）。 从检测到的光重建混浊介质（55）的内部的图像。 在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。 基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。 然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。