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    TEMPERATURE CONTROL OF PATIENTS DURING SURGERY
    1.
    发明申请
    TEMPERATURE CONTROL OF PATIENTS DURING SURGERY 有权
    手术期间患者的温度控制

    公开(公告)号：US20100094385A1

    公开(公告)日：2010-04-15

    申请号：US12440071

    申请日：2007-09-20

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Liesbeth van Pieterson ,  Gerhardus Wilhelmus Lucassen

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Liesbeth van Pieterson ,  Gerhardus Wilhelmus Lucassen

    IPC分类号： A61F7/00

    CPC分类号： A61N5/06 ,  A61B2017/00084 ,  A61N2005/0636 ,  A61N2005/0645 ,  A61N2005/0652

    摘要： An infrared radiant heating system for raising or maintaining a uniform core temperature of the body of a patient during surgery, substantially without affecting the temperature of the area surrounding the patient's body, comprising: infrared radiant heating means which in use is located in an unobtrusive position near the patient to provide radiant heat to the entire body or one or more parts of the body of the patient; and control means in communication with the heating means for controlling the intensity level and distribution of intensity of the radiant heat on the patient's body such that in use the skin temperature of the patient's body is raised or maintained within a predetermined range resulting in the uniform core body temperature, substantially without affecting the temperature of the area surrounding the patient's body.

    摘要翻译： 一种红外辐射加热系统，用于在手术过程中提高或保持患者身体的均匀核心温度，基本上不影响患者身体周围区域的温度，包括：使用中的红外辐射加热装置位于不引人注目的位置 靠近患者以向患者的身体的整个身体或身体的一个或多个部分提供辐射热; 以及与加热装置通信的控制装置，用于控制患者身体上的辐射强度的强度水平和分布，使得在使用中，患者身体的皮肤温度升高或维持在预定范围内，从而产生均匀的芯 体温，基本上不影响患者身体周围区域的温度。

    System and Method for Interacting With a Cell or Tissue in a Body
    2.
    发明申请
    System and Method for Interacting With a Cell or Tissue in a Body 审中-公开
    用于与身体中的细​​胞或组织相互作用的系统和方法

    公开(公告)号：US20080312532A1

    公开(公告)日：2008-12-18

    申请号：US12093720

    申请日：2006-11-14

    申请人： Liesbeth Van Pieterson ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhardus Wilhelmus Lucassen

    发明人： Liesbeth Van Pieterson ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhardus Wilhelmus Lucassen

    IPC分类号： A61B6/00 ,  A61B1/04

    CPC分类号： A61B5/05 ,  A61B1/041 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： A system (10, 100, 300, 400) is provided for identifying certain targeted cells or tissues in a body. The system (10, 100, 300, 400) preferably includes at least one ingestible capsule that accommodates or supports (20) at least one of an illuminating module (30, 114, 322, 422, 452), a detecting module (40, 124, 324, 424, 434, 454), an imaging module (50, 326, 432, 456), a control module (60), or a reservoir (70, 132, 312, 412, 442) suitable for retaining and releasing one or more nanoshells. A method (200) is also provided for employing the system (10, 100, 300, 400) to detect, image or otherwise interact with diseased or abnormal cells and/or tissues in a body. The system (10, 100, 300, 400) and method (200) provided allow for improved diagnosing, treating and imaging techniques and for increased sensitivity and specificity in efficiently distinguishing targeted diseased or abnormal cells or tissue from surrounding healthy cells or tissue.

    摘要翻译： 提供系统（10,100,300,400）用于识别身体中的某些靶向细胞或组织。 该系统（10,100,300,400）优选地包括至少一个可摄取的胶囊，其容纳或支撑（20）照明模块（30,114,322,422,452），检测模块（40， 124,324,424,434,454），成像模块（50,326,432,465），控制模块（60）或适于保持和释放的储存器（70,132,312,412,442） 一个或多个纳米壳。 还提供了一种方法（200），其用于使用所述系统（10,100,300,400）来检测，图像或以其他方式与身体中的病变或异常细胞和/或组织相互作用。 提供的系统（10,100,300,400）和方法（200）允许改进的诊断，治疗和成像技术以及用于增强敏感性和特异性，从而有效区分靶向患病或异常细胞或组织与周围健康细胞或组织。

    Temperature control of patients during surgery
    4.
    发明授权
    Temperature control of patients during surgery 有权
    手术期间患者的温度控制

    公开(公告)号：US08812132B2

    公开(公告)日：2014-08-19

    申请号：US12440071

    申请日：2007-09-20

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Liesbeth van Pieterson ,  Gerhardus Wilhelmus Lucassen

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Liesbeth van Pieterson ,  Gerhardus Wilhelmus Lucassen

    IPC分类号： A61F7/00

    CPC分类号： A61N5/06 ,  A61B2017/00084 ,  A61N2005/0636 ,  A61N2005/0645 ,  A61N2005/0652

    摘要： An infrared radiant heating system for raising or maintaining a uniform core temperature of the body of a patient during surgery, substantially without affecting the temperature of the area surrounding the patient's body, includes an infrared radiant heater located near the patient to provide radiant heat to the entire body or one or more parts of the body of the patient. The system further includes a controller in communication with the heater for controlling the intensity level and distribution of intensity of the radiant heat on the patient's body such that the skin temperature of the patient's body is raised or maintained within a predetermined range resulting in the uniform core body temperature, substantially without affecting the temperature of the area surrounding the patient's body.

    摘要翻译： 用于在手术期间升高或保持患者身体的均匀核心温度的红外辐射加热系统基本上不影响患者身体周围区域的温度，包括位于患者附近的红外辐射加热器，以向患者提供辐射热 整个身体或患者身体的一个或多个部分。 该系统还包括与加热器连通的控制器，用于控制患者身体上的辐射强度的强度水平和分布，使得患者身体的皮肤温度升高或维持在预定范围内，导致均匀的芯 体温，基本上不影响患者身体周围区域的温度。

    APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE
    7.
    发明申请
    APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE 审中-公开
    用于相关组织的光学分析的装置

    公开(公告)号：US20140200459A1

    公开(公告)日：2014-07-17

    申请号：US13995967

    申请日：2011-12-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

    IPC分类号： A61B5/00 ,  A61B18/18

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0084 ,  A61B5/4836 ,  A61B18/18 ,  G01N21/25

    摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

    摘要翻译： 本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括： 光源104和被布置成测量光谱的检测器106,108。 这使得能够确定指示胆汁浓度的第一参数。 本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。 根据具体实施例，该装置还包括介入装置112。

    DETERMINATION OF A LIPID WATER RATIO
    8.
    发明申请
    DETERMINATION OF A LIPID WATER RATIO 有权
    脂肪水比的测定

    公开(公告)号：US20130026367A1

    公开(公告)日：2013-01-31

    申请号：US13641229

    申请日：2011-04-18

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： G01N21/59 ,  G01N21/49

    CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

    摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

    摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

    Classification of tumor tissue with a personalized threshold
    9.
    发明授权
    Classification of tumor tissue with a personalized threshold 有权
    具有个性化阈值的肿瘤组织分类

    公开(公告)号：US09498136B2

    公开(公告)日：2016-11-22

    申请号：US14112555

    申请日：2012-04-10

    申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    IPC分类号： A61B5/00 ,  A61B1/00 ,  G01N21/64

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

    摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

    摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。