公开(公告)号：US09468379B2

公开(公告)日：2016-10-18

申请号：US13641229

申请日：2011-04-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： G01N21/359 ,  A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

公开(公告)号：US20130026367A1

公开(公告)日：2013-01-31

申请号：US13641229

申请日：2011-04-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： G01N21/59 ,  G01N21/49

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

公开(公告)号：US20140117256A1

公开(公告)日：2014-05-01

申请号：US14127719

申请日：2012-06-21

申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

公开(公告)号：US20140121538A1

公开(公告)日：2014-05-01

申请号：US14127692

申请日：2012-06-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

IPC分类号： A61B5/00 ,  A61B10/02 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07

CPC分类号： A61B1/00009 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B10/0233 ,  F04C2270/0421 ,  Y10T29/49826

摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.

摘要翻译： 提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

公开(公告)号：US20140142563A1

公开(公告)日：2014-05-22

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B19/00 ,  A61B18/14

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

摘要翻译： 本发明涉及一种能量应用计划装置，用于规划能量到诸如肿瘤的物体（3）的应用。 能量应用元件表示代表诸如包括用于施加能量的能量施加部分和感测部分（7）的消融针的能量施加元件（5）。 能量施加元件（5）相对于物体（3）的布置根据能量施加部分和感测部分（7）相对于能量施加元件（5）的位置来确定，如由 能量应用元素表示，并取决于对象表示。 因此，能量的施加不仅可以被规划，使得能量的应用按照需要执行，而且还使得物体和/或物体的周围是期望的。 这样可以提高规划程序。

公开(公告)号：US09757201B2

公开(公告)日：2017-09-12

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabė ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabė ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B18/04 ,  A61B19/00 ,  A61B18/14 ,  A61B18/00 ,  A61B34/10

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

公开(公告)号：US20120029360A1

公开(公告)日：2012-02-02

申请号：US13264388

申请日：2010-04-12

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Habers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Habers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/6848

摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accommodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.

摘要翻译： 针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括 斜面，切割面和用于容纳纤维的至少一个通道，并且其中光纤的端部位于通道中，并且光纤的端表面位于一个切割平面上。 通过这些方面，可以促进将针引入组织中。 本发明的另一方面是制造这种针的方法。

公开(公告)号：US20110251494A1

公开(公告)日：2011-10-13

申请号：US13129171

申请日：2009-11-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Rami Nachabe

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/1459 ,  A61B5/6848 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/3401 ,  A61B18/1477 ,  A61B2017/00057 ,  A61B2018/1425

摘要： Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.

摘要翻译： 针刺干预广泛用于肿瘤学领域，用于检查组织的活组织检查，以检查组织是否癌变。 要使这些干预措施更为可靠，就需要在针前方使用什么样的组织。 实现这一目标的一个方法是利用光谱学。 这需要将纤维整合到针中。 这些纤维用于传递光以照射针前面的组织并收集来自组织的反射光。 本发明提出将光纤远端集成在针的倾斜斜面中，使得至少一个源 - 检测器光纤对的距离大于针的外径。

公开(公告)号：US20110218445A1

公开(公告)日：2011-09-08

申请号：US13129206

申请日：2009-06-15

申请人： Augustinus Laurentius Braun ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Emmanuel Desjardins ,  Rami Nachabe ,  Bernardus Wilhelmus Johannes Wassink ,  Franciscus Marinus Antonius Maria Van Gaal ,  Nenad Mihajlovic ,  Drazenko Babic

发明人： Augustinus Laurentius Braun ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Emmanuel Desjardins ,  Rami Nachabe ,  Bernardus Wilhelmus Johannes Wassink ,  Franciscus Marinus Antonius Maria Van Gaal ,  Nenad Mihajlovic ,  Drazenko Babic

IPC分类号： A61B6/00 ,  B21G3/18

CPC分类号： A61B5/6848 ,  A61B5/0075 ,  A61B5/0084

摘要： Needles equipped with fibres allow tissue inspection based on optical spectroscopy to diagnose whether tissue is cancerous or not. This requires integration of optical fibers into needles. The problem is how to manufacture the needle having at least one fiber exit at the distal end of the needle, where the fiber does not obstruct the hollow part of the needle if present as well as does not extend beyond the outer cylinder geometry. To solve this problem we propose to manufacture the needle consisting of four parts: an inner cylinder tube, an outer hollow cylinder tube, a needle tip part with integrated fiber exit and a holder part, wherein the hollow spacing between the inner and the outer cylinder is larger or equal to the outer diameter of the fibers, the inner and the outer cylinder are mounted in the holder part and where the tip part is mounted on the two cylinders.

摘要翻译： 配备纤维的针头允许基于光谱的组织检查来诊断组织是否是癌变的。 这需要将光纤集成到针中。 问题是如何制造在针的远端具有至少一个纤维出口的针，其中纤维不会阻塞针的中空部分，如果存在，并且不延伸超出外筒几何形状。 为了解决这个问题，我们建议制造由四部分组成的针：内筒管，外空心筒管，具有集成纤维出口的针尖部分和保持器部分，其中内筒和外筒之间的中空间隔 大于或等于纤维的外径，内筒和外筒安装在保持器部分中，并且尖端部分安装在两个气缸上。

公开(公告)号：US08812080B2

公开(公告)日：2014-08-19

申请号：US13376702

申请日：2010-06-07

申请人： Rami Nachabe ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Drazenko Babic ,  Nenad Mihajlovic

发明人： Rami Nachabe ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Marjolein Van Der Voort ,  Adrien Desjardins ,  Drazenko Babic ,  Nenad Mihajlovic

IPC分类号： A61B5/05

CPC分类号： G06F19/321 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/14503 ,  A61B5/6848 ,  A61B5/7435 ,  A61B5/7475 ,  A61B6/467 ,  A61B6/469 ,  A61B6/545 ,  A61B8/0833 ,  A61B8/461 ,  A61B8/467 ,  A61B8/469 ,  A61B8/585 ,  A61B17/3401 ,  A61B17/3403 ,  A61B34/20 ,  A61B90/92 ,  A61B90/96 ,  A61B90/98 ,  A61B2017/00199 ,  A61B2017/00225 ,  A61B2034/2055 ,  A61B2090/376 ,  A61B2090/3908 ,  A61B2090/3945 ,  A61B2562/08 ,  G06F19/00 ,  G16H40/63

摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.

摘要翻译： 针头广泛用于介入放射学。 每个医疗应用都需要特殊的针型。 同样适用于光子针，分析取决于临床医生的应用类型。 因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。 因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息 成像模式可用于指导处理。 在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。