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    GROUP OF NOVEL ENANTIOSLEECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY
    3.
    发明申请
    GROUP OF NOVEL ENANTIOSLEECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY 失效
    具有广泛基质特征的新型强化微生物氮化物组

    公开(公告)号：US20100047863A1

    公开(公告)日：2010-02-25

    申请号：US12296057

    申请日：2007-04-05

    申请人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    发明人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    IPC分类号： C12P21/06 ,  C12P13/02 ,  C12N15/74 ,  C12N1/21 ,  C12N15/63 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C12N9/88 ,  C12P13/02 ,  C12P41/006

    摘要： The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitrites.

    摘要翻译： 本发明提供了编码具有腈水合酶（NHase）[E.C.]的酶的多核苷酸或一对多核苷酸。 4.2.1.84]活动。 此外，提供了包含所公开的多核苷酸或一对多核苷酸的载体和宿主及其生产方法。 此外，本发明涉及一对多肽或具有NHase活性的融合蛋白，特异性结合所述一对多肽或融合蛋白的抗体，在严格条件下与所公开的多核苷酸特异性杂交的引物或探针，或者 一对多核苷酸，包含多核苷酸或一对多核苷酸的组合物，一对多肽或融合蛋白，本发明的抗体和/或一种或多种引物或探针以及生产酰胺的方法，其包括对映选择性转化 亚硝酸盐

    Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
    4.
    发明授权
    Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity 失效
    一组具有广泛底物特异性的新型对映选择性微生物腈水合酶

    公开(公告)号：US08470576B2

    公开(公告)日：2013-06-25

    申请号：US12296057

    申请日：2007-04-05

    申请人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    发明人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    IPC分类号： C12N9/78 ,  C12N15/00 ,  C12N1/20 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/88 ,  C12P13/02 ,  C12P41/006

    摘要： The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles.

    摘要翻译： 本发明提供了编码具有腈水合酶（NHase）[E.C.]的酶的多核苷酸或一对多核苷酸。 4.2.1.84]活动。 此外，提供了包含所公开的多核苷酸或一对多核苷酸的载体和宿主及其生产方法。 此外，本发明涉及一对多肽或具有NHase活性的融合蛋白，特异性结合所述一对多肽或融合蛋白的抗体，在严格条件下与所公开的多核苷酸特异性杂交的引物或探针，或者 一对多核苷酸，包含多核苷酸或一对多核苷酸的组合物，一对多肽或融合蛋白，本发明的抗体和/或一种或多种引物或探针以及生产酰胺的方法，其包括对映选择性转化 腈类