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    Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
    5.
    发明授权
    Stable effervescent bisphosphonate formulations with rapid solubilization characteristics 有权
    稳定的泡腾双膦酸盐配方具有快速溶解特性

    公开(公告)号：US09592195B2

    公开(公告)日：2017-03-14

    申请号：US13991523

    申请日：2011-12-05

    申请人： Marshall A. Hayward ,  Timo Schmidt

    发明人： Marshall A. Hayward ,  Timo Schmidt

    IPC分类号： A61K9/46 ,  A61K31/683 ,  A61K31/663

    CPC分类号： A61K9/0007 ,  A61K31/663

    摘要： A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

    摘要翻译： 稳定的起泡片，颗粒或粉末组合物，其不含可能与起泡有机酸组分反应的赋形剂，其包含有效量的双膦酸盐骨吸收抑制剂，起泡有机酸组分，起泡基质组分; 其中所述组合物不含多元醇粘合剂和压片润滑剂; 干燥失重为0.25％（m / m）以下; 在5-20℃之间放置在3至8个液体盎司的水中时，其完全崩解时间不超过180秒; 并且所述二膦酸盐作为微粉化颗粒掺入或通过喷雾干燥并在2分钟内完全溶解在水中而不搅拌。

    Motor vehicle with lowerable drive unit
    6.
    发明授权
    Motor vehicle with lowerable drive unit 有权
    机动车具有可降低的驱动单元

    公开(公告)号：US07232003B2

    公开(公告)日：2007-06-19

    申请号：US10875609

    申请日：2004-06-23

    申请人： Jürgen Bürkle ,  Timo Schmidt ,  Karsten Unger

    发明人： Jürgen Bürkle ,  Timo Schmidt ,  Karsten Unger

    IPC分类号： B60K28/14

    CPC分类号： B60R21/34

    摘要： In a motor vehicle comprising a vehicle body having a support structure for supporting a main drive unit and at least one support block disposed on the support structure by which the main drive unit is supported in the vehicle body, each support block comprises bottom and top parts which are movable relative to each other and provided with an operating mechanism for causing such movement for lowering the drive unit when the motor vehicle is involved in a collision.

    摘要翻译： 在包括具有用于支撑主驱动单元的支撑结构的车体和设置在主驱动单元被支撑在车身中的支撑结构上的至少一个支撑块的机动车辆中，每个支撑块包括底部和顶部 它们可相对于彼此移动并且设置有用于当机动车辆参与碰撞时使该驱动单元下降的操作机构。

    CELL CULTURE INSERT
    8.
    发明申请
    CELL CULTURE INSERT 有权
    细胞文化插入

    公开(公告)号：US20130267019A1

    公开(公告)日：2013-10-10

    申请号：US13878143

    申请日：2010-10-08

    申请人： Timo Schmidt ,  Lothar Just ,  Holger Becker

    发明人： Timo Schmidt ,  Lothar Just ,  Holger Becker

    IPC分类号： C12M1/12

    CPC分类号： C12M25/04 ,  C12M23/12 ,  C12M23/44 ,  C12M25/14 ,  C12M35/08

    摘要： A cell culture device allows co-cultivation on both sides of a membrane and has an outer tubular body with upper end having an opening and lower end closed by the membrane, an inner surface and an outer surface, which can be colonized with biological material, a complementary tubular body whose inner diameter fits onto the outer diameter of the lower end and a hanger component with upper end and a lower end. A flange extends from the upper end and the outer diameter component fits the inner diameter of the outer tubular body. The outer tubular body in a first step is connected to the complementary tubular body to form a standing insert for a first cell cultivation, and in a second step wherein the outer tubular body is disengaged from the complementary tubular body and is attached to the hanger component for a second cell cultivation.

    摘要翻译： 细胞培养装置允许在膜的两侧共同培养，并且具有外管状体，其上端具有通过膜封闭的开口和下端，内表面和外表面，其可以被生物材料定殖， 其内径配合到下端的外径上的互补管状体和具有上端和下端的衣架部件。 凸缘从上端延伸并且外径部件配合外管体的内径。 第一步骤中的外部管状体连接到互补管状体以形成用于第一细胞培养的站立插入物，并且在第二步骤中，外部管状体与互补管状体脱离并附接到衣架部件 用于第二细胞培养。

    Device for changing the angle of rotation of a camshaft relative to a drive wheel of an internal combustion engine
    9.
    发明授权
    Device for changing the angle of rotation of a camshaft relative to a drive wheel of an internal combustion engine 失效
    用于改变凸轮轴相对于内燃机的驱动轮的旋转角度的装置

    公开(公告)号：US06912982B2

    公开(公告)日：2005-07-05

    申请号：US10783954

    申请日：2004-02-20

    申请人： Kai Lehmann ,  Timo Schmidt

    发明人： Kai Lehmann ,  Timo Schmidt

    IPC分类号： F01L1/34

    CPC分类号： F01L1/34 ,  F01L2001/34426 ,  F01L2001/3443

    摘要： In a device for changing the angle of rotation of a camshaft arranged in a cylinder head of an internal combustion engine relative to a drive wheel of the internal combustion engine, wherein a hydraulic adjusting arrangement is arranged between the drive wheel and the camshaft and is connected to a fluid circuit of the internal combustion engine, and wherein the fluid supply to the adjusting arrangement is controlled by an on/off valve, the on/off valve is mounted near the camshaft and is supplied with fluid via the camshaft.

    摘要翻译： 在用于改变配置在内燃机的气缸盖中的凸轮轴相对于内燃机的驱动轮的旋转角度的装置中，其中液压调节装置布置在驱动轮和凸轮轴之间并被连接 连接到内燃机的流体回路，并且其中通过开关阀控制对调节装置的流体供应，开/关阀安装在凸轮轴附近并经由凸轮轴供给流体。

    Cell culture insert
    10.
    发明授权
    Cell culture insert 有权
    细胞培养插入物

    公开(公告)号：US09267101B2

    公开(公告)日：2016-02-23

    申请号：US13878143

    申请日：2010-10-08

    申请人： Timo Schmidt ,  Lothar Just ,  Holger Becker

    发明人： Timo Schmidt ,  Lothar Just ,  Holger Becker

    IPC分类号： C12M1/12 ,  C12M1/32 ,  C12M3/00 ,  C12M1/42

    CPC分类号： C12M25/04 ,  C12M23/12 ,  C12M23/44 ,  C12M25/14 ,  C12M35/08

    摘要： A cell culture device allows co-cultivation on both sides of a membrane and has an outer tubular body with upper end having an opening and lower end closed by the membrane, an inner surface and an outer surface, which can be colonized with biological material, a complementary tubular body whose inner diameter fits onto the outer diameter of the lower end and a hanger component with upper end and a lower end. A flange extends from the upper end and the outer diameter component fits the inner diameter of the outer tubular body. The outer tubular body in a first step is connected to the complementary tubular body to form a standing insert for a first cell cultivation, and in a second step wherein the outer tubular body is disengaged from the complementary tubular body and is attached to the hanger component for a second cell cultivation.

    摘要翻译： 细胞培养装置允许在膜的两侧共同培养，并且具有外管状体，其上端具有通过膜封闭的开口和下端，内表面和外表面，其可以被生物材料定殖， 其内径配合到下端的外径上的互补管状体和具有上端和下端的衣架部件。 凸缘从上端延伸并且外径部件配合外管体的内径。 第一步骤中的外部管状体连接到互补管状体以形成用于第一细胞培养的站立插入物，并且在第二步骤中，外部管状体与互补管状体脱离并附接到衣架部件 用于第二细胞培养。