公开(公告)号：US06576214B2

公开(公告)日：2003-06-10

申请号：US09867190

申请日：2001-05-29

申请人： Bing Zhou ,  Michael A. Rueter ,  Lap-Keung Lee ,  Bruce P. Pelrine

发明人： Bing Zhou ,  Michael A. Rueter ,  Lap-Keung Lee ,  Bruce P. Pelrine

IPC分类号： C01B1501

CPC分类号： C01B15/029 ,  B01J21/18 ,  B01J23/38 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0203 ,  B01J37/0211 ,  C07D301/12 ,  Y02P20/52 ,  Y10S977/775 ,  Y10S977/777 ,  Y10S977/779 ,  Y10S977/836 ,  Y10S977/895 ,  Y10S977/926

摘要： A process for catalytically directly producing hydrogen peroxide (H2O2) product from hydrogen and oxygen-containing feeds by contacting them with a supported noble metal phase-controlled catalyst and a suitable organic liquid solvent having a Solvent Selection Parameter (SSP) between 0.14×10−4 and 5.0×10−4 at reaction condition of 0-100° C. temperature and 100-3,000 psig pressure. Unconverted feed gas and organic liquid solvent solution are usually recovered and recycled back to the reactor along with any recovered catalyst. If desired, the hydrogen peroxide product can be fed together with an organic chemical feedstock such as propylene and with the organic liquid solvent solution into a second catalytic reaction step which oxidizes the feedstock to produce a desired crude oxidized organic product such as propylene oxide, which may be purified by distillation steps and recovered from the solvent solution.

公开(公告)号：US06875409B1

公开(公告)日：2005-04-05

申请号：US10038120

申请日：2001-11-09

申请人： Bing Zhou ,  Lap-Keung Lee ,  Naresh J. Suchak

发明人： Bing Zhou ,  Lap-Keung Lee ,  Naresh J. Suchak

IPC分类号： B01J23/00

CPC分类号： B01J23/002 ,  B01D53/944 ,  B01D2253/112 ,  B01D2255/1021 ,  B01D2255/2073 ,  B01D2255/20738 ,  B01D2255/20746 ,  B01D2255/20761 ,  B01D2255/91 ,  B01J23/78 ,  B01J23/83 ,  B01J23/894 ,  B01J23/8986 ,  B01J37/0201 ,  B01J37/34 ,  B01J2523/00 ,  B01J2523/17 ,  B01J2523/3706 ,  B01J2523/72 ,  B01J2523/25

摘要： A bi-functional oxidation catalyst and process for catalytic oxidation and removal of nitrogen oxides (NOx) from combustion gases derived from combustion of carbonaceous fuels such as coal, oil, or natural gas. The bi-functional catalyst includes adsorption and oxidation function metal oxides provided in adjacent close intimate contact by utilizing a binding agent, such as carboxylic acid and calcining to provide a metal oxide complex having a crystalline form. Such nitrogen oxides (NOx) contained in the combustion gases are initially catalytically oxidized to at least about 50 vol % NO2 and some higher oxides by contact with the bi-functional catalyst at 170-550° F. temperature. The combustion gas containing the partially oxidized NOx is then preferably further chemically oxidized by being mixed with a chemical oxidant such as ozone (O3) in a molar ratio of the chemical oxidant3 to NOx in the range of 0.5:1-1.2:1 to produce higher oxides of nitrogen such as substantially N2O5. The further treated combustion gas containing the N2O5 is next scrubbed with a suitable scrubbing liquid such as water to effectively remove the nitrogen oxides (NOx) and produce a clean treated flue gas stream containing less than about 15 ppm nitrogen oxides and suitable for environmentally safe discharge to the atmosphere.

摘要翻译： 一种双功能氧化催化剂和从燃烧碳，燃料如煤，油或天然气的燃烧产生的燃烧气体催化氧化和除去氮氧化物（NOx）的方法。 双功能催化剂包括通过利用粘合剂（例如羧酸）和煅烧以提供具有结晶形式的金属氧化物络合物在相邻紧密接触中提供的吸附和氧化功能金属氧化物。 包含在燃烧气体中的这种氮氧化物（NOx）在170-550°F温度下与双功能催化剂接触，最初催化氧化至至少约50vol％的NO 2和一些较高的氧化物。 含有部分氧化的NOx的燃烧气体然后优选通过与化学氧化剂例如臭氧（O 3）以化学氧化剂3与NOx的摩尔​​比在0.5：1-1.2:1的范围内混合而进一步化学氧化，以产生 较高的氮氧化物，例如基本上是N 2 O 5。 接下来用含有N2O5的处理过的燃烧气体用合适的洗涤液如水洗涤以有效去除氮氧化物（NOx）并产生含有小于约15ppm氮氧化物并且适于环境安全排放的清洁处理的烟道气流 到大气。

公开(公告)号：US06919065B2

公开(公告)日：2005-07-19

申请号：US10431693

申请日：2003-05-07

申请人： Bing Zhou ,  Lap-Keung Lee

发明人： Bing Zhou ,  Lap-Keung Lee

IPC分类号： B01J21/18 ,  B01J23/38 ,  B01J23/40 ,  B01J35/00 ,  B01J37/02 ,  C01B15/029 ,  C07D301/12 ,  C01B15/01 ,  B01J21/08 ,  B01J21/12 ,  B01J23/00

CPC分类号： C01B15/029 ,  B01J21/18 ,  B01J23/38 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0203 ,  B01J37/0211 ,  C07D301/12 ,  Y02P20/52 ,  Y10S977/775 ,  Y10S977/777 ,  Y10S977/779 ,  Y10S977/836 ,  Y10S977/895 ,  Y10S977/926

摘要： A particulate supported noble metal phase-controlled catalyst material having 5-1000 μm surface area of 50μ500 m2/gm is provided for use in direct catalytic production of hydrogen peroxide (H2O2) product from hydrogen and oxygen-containing feedstreams. The catalyst is made by depositing phase controlled crystals of a noble metal such as palladium on a suitable particulate support material such as carbon black, by utilizing a precursor solution of the metal and a suitable control ionic polymer having molecular weight of 300-8000 such as sodium polyacrylate in a selected metal to polymer molar ratio of 1:0.1 to 1:10, which procedure provides desired phase control of the noble metal atoms to form widely dispersed minute noble metal crystals on the support material. The invention includes methods for making the catalyst, and also a process for utilizing the catalyst to directly produce high yields of hydrogen peroxide (H2O2) product from hydrogen and oxygen-containing gaseous feedstreams.

摘要翻译： 提供具有5-1000mum表面积为50mu500m 2 / gm的颗粒状负载的贵金属相控催化剂材料用于直接催化生产过氧化氢（H 2 N 2 产物从氢和含氧进料流中获得。 通过使用金属的前体溶液和分子量为300-8000的合适的对照离子聚合物（如分子量为300-8000），将贵金属如钯的相控晶体沉积在合适的颗粒载体材料如炭黑上来制备催化剂，例如 聚丙烯酸钠以选择的金属与聚合物的摩尔比为1:0.1至1:10，该方法提供贵金属原子的期望的相位控制，以在载体材料上形成广泛分散的微小贵金属晶体。 本发明包括制备催化剂的方法，以及利用催化剂从氢气和氧气直接产生高产率的过氧化氢（H 2 O 2 O 2 H 2）产物的方法。 的气态进料流。

公开(公告)号：US06168775A

公开(公告)日：2001-01-02

申请号：US09140265

申请日：1998-08-26

申请人： Bing Zhou ,  Lap-Keung Lee

发明人： Bing Zhou ,  Lap-Keung Lee

IPC分类号： B01J2118

CPC分类号： B01J37/0203 ,  B01J21/18 ,  B01J23/38 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0211 ,  C01B15/029

摘要： A particulate supported noble metal phase-controlled catalyst material having 5-1000 &mgr;m surface area of 50&mgr;500 m2/gm is provided for use in direct catalytic production of hydrogen peroxide (H2O2) product from hydrogen and oxygen-containing feedstreams. The catalyst is made by depositing phase controlled crystals of a noble metal such as palladium on a suitable particulate support material such as carbon black, by utilizing a precursor solution of the metal and a suitable control ionic polymer having molecular weight of 300-8000 such as sodium polyacrylate in a selected metal to polymer molar ratio of 1:0.1 to 1:10, which procedure provides desired phase control of the noble metal atoms to form widely dispersed minute noble metal crystals on the support material. The invention includes methods for making the catalyst, and also a process for utilizing the catalyst to directly produce high yields of hydrogen peroxide (H2O2) product from hydrogen and oxygen-containing gaseous feedstreams.

摘要翻译： 提供具有5-500m 2 / gm的5-1000mum表面积的颗粒状负载的贵金属相控催化剂材料，用于从氢气和含氧进料流直接催化生产过氧化氢（H 2 O 2）产物。 通过使用金属的前体溶液和分子量为300-8000的合适的对照离子聚合物（如分子量为300-8000），将贵金属如钯的相控晶体沉积在合适的颗粒载体材料如炭黑上来制备催化剂，例如 聚丙烯酸钠以选择的金属与聚合物的摩尔比为1:0.1至1:10，该方法提供贵金属原子的期望的相位控制，以在载体材料上形成广泛分散的微小贵金属晶体。 本发明包括制备催化剂的方法，以及利用催化剂从氢气和含氧气态进料流直接产生高产率的过氧化氢（H 2 O 2）产物的方法。

公开(公告)号：US06500968B2

公开(公告)日：2002-12-31

申请号：US09733154

申请日：2000-12-08

申请人： Bing Zhou ,  Michael A. Rueter

发明人： Bing Zhou ,  Michael A. Rueter

IPC分类号： C07D30112

CPC分类号： B01J21/18 ,  B01J23/38 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0203 ,  B01J37/0211 ,  C01B15/029

摘要： A process for producing oxidized organic chemical products such as propylene oxide from various organic chemical feedstocks utilizing as oxidant directly produced hydrogen peroxide (H2O2) intermediate oxidizing agent. The hydrogen peroxide intermediate is directly produced from hydrogen and oxygen feeds plus a suitable solvent in a first catalytic reaction step utilizing an active supported phase-controlled noble metal catalyst at reaction conditions of 0-100° C. temperature and 300-3,000 psig pressure. An organic chemical feedstock such as propylene together with the hydrogen peroxide intermediate and solvent solution are fed into a second catalytic reactor maintained at 0-150° C. temperature and 15-1,500 psig pressure and oxidized to produce a desired crude oxidized organic product such as propylene oxide, which is purified by distillation steps and recovered from the solvent solution.

摘要翻译： 使用氧化剂直接生产过氧化氢（H 2 O 2）中间体氧化剂，从各种有机化学原料生产氧化有机化学产品如环氧丙烷的方法。 在0-100℃温度和300-3000psig压力的反应条件下，使用活性支持相控制的贵金属催化剂，在第一催化反应步骤中，由氢气和氧气进料加合适的溶剂直接生产过氧化氢中间体。 将有机化学原料如丙烯与过氧化氢中间体和溶剂溶液一起进料至保持在0-150℃温度和15-1,500psig压力的第二催化反应器中，并氧化以产生所需的粗氧化有机产物，例如 环氧丙烷，其通过蒸馏步骤纯化并从溶剂溶液中回收。

公开(公告)号：US20120020872A1

公开(公告)日：2012-01-26

申请号：US12840723

申请日：2010-07-21

申请人： Sukesh Parasher ,  Michael A. Rueter ,  Bing Zhou

发明人： Sukesh Parasher ,  Michael A. Rueter ,  Bing Zhou

IPC分类号： B01J23/44 ,  C01B15/01

CPC分类号： B01J35/0013 ,  B01J21/08 ,  B01J23/40 ,  B01J23/42 ,  B01J23/44 ,  B01J35/002 ,  B01J35/006 ,  B01J35/08 ,  B01J37/0203 ,  B01J37/16 ,  B01J37/18 ,  C01B15/029

摘要： Method for making a direct synthesis hydrogen peroxide catalyst includes (i) mixing together a solvent, a plurality of noble metal catalyst atoms, and a plurality of organic dispersing agent molecules, the organic dispersing agent molecules each including at least one functional group capable of bonding with the noble metal catalyst atoms; (ii) reacting the organic dispersing agent with the catalyst atoms to form complexed catalyst atoms and forming a plurality of catalytic nanoparticles from the complexed catalyst atoms; (iii) supporting the catalytic nanoparticles on a support material; and (iv) reducing the catalyst atoms at a temperature of at least 351° C. to yield a supported and activated direct synthesis hydrogen peroxide catalyst.

摘要翻译： 制备直接合成过氧化氢催化剂的方法包括（i）将溶剂，多种贵金属催化剂原子和多种有机分散剂分子混合在一起，所述有机分散剂分子各自包含至少一个能够键合的官能团 与贵金属催化剂原子; （ii）使有机分散剂与催化剂原子反应以形成络合的催化剂原子并从络合的催化剂原子形成多个催化纳米颗粒; （iii）将催化纳米颗粒负载在载体材料上; 和（iv）在至少351℃的温度下还原催化剂原子，得到负载和活化的直接合成过氧化氢催化剂。

公开(公告)号：US07632774B2

公开(公告)日：2009-12-15

申请号：US11393334

申请日：2006-03-30

申请人： Michael A. Rueter ,  Sukesh Parasher ,  Cheng Zhang ,  Bing Zhou

发明人： Michael A. Rueter ,  Sukesh Parasher ,  Cheng Zhang ,  Bing Zhou

IPC分类号： B01J31/16 ,  B01J21/00 ,  B01J23/00 ,  B01J27/053 ,  C01B15/01

CPC分类号： C01B15/029 ,  B01J21/08 ,  B01J23/44 ,  B01J35/0013 ,  B01J37/0207 ,  B01J37/0211 ,  B01J37/06 ,  B01J37/18

摘要： Supported catalysts include an inorganic solid support such as silica that is functionalized to have inorganic acid functional groups attached thereto. The functionalization of the support material is optimized by (i) limiting the amount of water present during the functionalization reaction, (ii) using a concentrated mineral acid or derivative thereof, and/or (iii) increasing the reaction temperature and/or reaction pressure. The acid-functionalized support material serves as a support for a metal nanoparticle catalyst. The nanocatalyst particles are preferably bonded to the support material through an organic molecule, oligomer, or polymer having functional groups that can bind to both the nanocatalyst particles and to the support material. The supported catalysts can advantageously be used for the direct synthesis of hydrogen peroxide from hydrogen and oxygen feed streams.

摘要翻译： 负载型催化剂包括无机固体载体如二氧化硅，其被官能化以具有连接到其上的无机酸官能团。 通过（i）限制官能化反应期间存在的水的量，（ii）使用浓缩的无机酸或其衍生物，和/或（iii）提高反应温度和/或反应压力来优化载体材料的功能化 。 酸官能化的载体材料用作金属纳米颗粒催化剂的载体。 纳米催化剂颗粒优选通过具有可结合纳米催化剂颗粒和载体材料的官能团的有机分子，低聚物或聚合物结合到载体材料上。 负载型催化剂可有利地用于从氢气和氧气进料流直接合成过氧化氢。

公开(公告)号：US07718710B2

公开(公告)日：2010-05-18

申请号：US11378057

申请日：2006-03-17

申请人： Cheng Zhang ,  Sukesh Parasher ,  Michael A. Rueter ,  Bing Zhou

发明人： Cheng Zhang ,  Sukesh Parasher ,  Michael A. Rueter ,  Bing Zhou

IPC分类号： C09K3/00 ,  B01J31/00 ,  B01J23/00

CPC分类号： B01J23/40 ,  B01J13/0034 ,  B01J13/0039 ,  B01J13/0043 ,  B01J35/0013 ,  B22F1/0022 ,  B22F9/26 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2201/013

摘要： A method for manufacturing stable concentrated colloids containing metal nanoparticles in which the colloid is stabilized by adding a base. This allows the metal particles to be formed in higher concentration without forming larger agglomerates and/or precipitating. The method of manufacturing the stable colloidal metal nanoparticles of the present invention generally includes (i) providing a solution comprising a plurality of metal atoms, (ii) providing a solution comprising a plurality of organic agent molecules, each organic agent molecule comprising at least one functional group capable of bonding to the metal atoms, (iii) reacting the metal atoms in solution with the organic agent molecules in solution to form a mixture comprising a plurality of complexed metal atoms, (iv) reducing the complexed metal atoms in the mixture using a reducing agent to form a plurality of nanoparticles, and (v) adding an amount of a base to the mixture, thereby improving the stability of the nanoparticles in the mixture. The base may be added before or after forming the nanoparticles.

摘要翻译： 一种制备含有金属纳米粒子的稳定浓缩胶体的方法，其中胶体通过加入碱稳定。 这允许金属颗粒以更高的浓度形成而不形成较大的附聚物和/或沉淀。 制备本发明的稳定胶体金属纳米粒子的方法通常包括（i）提供包含多个金属原子的溶液，（ii）提供包含多个有机试剂分子的溶液，每个有机试剂分子包含至少一个 能够与金属原子键合的官能团，（iii）使溶液中的金属原子与溶液中的有机试剂分子反应，形成包含多个络合的金属原子的混合物，（iv）使用 还原剂形成多个纳米颗粒，和（v）向混合物中加入一定量的碱，从而提高混合物中纳米颗粒的稳定性。 可以在形成纳米颗粒之前或之后加入碱。

公开(公告)号：US07514476B2

公开(公告)日：2009-04-07

申请号：US11378877

申请日：2006-03-17

申请人： Sukesh Parasher ,  Cheng Zhang ,  Michael A. Rueter ,  Bing Zhou

发明人： Sukesh Parasher ,  Cheng Zhang ,  Michael A. Rueter ,  Bing Zhou

IPC分类号： C09K3/00 ,  C01B15/029

CPC分类号： B01J35/0013 ,  B01J13/0043 ,  B01J23/40 ,  B01J37/18 ,  B82Y30/00

摘要： Metal-containing colloids are manufactured by reacting a plurality of metal ions and a plurality of organic agent molecules to form metal complexes in a mixture having a pH greater than about 4.25. The metal complexes are reduced for at least 0.5 hour to form stable colloidal nanoparticles. The extended reduction time improves the stability of the colloidal particles as compared to shorter reduction times. The stability of the colloidal particles allows for colloids with higher concentrations of metal to be formed. The concentration of metal in the colloid is preferably at least about 150 ppm by weight.

摘要翻译： 含金属胶体通过使多种金属离子和多种有机试剂分子反应，在pH大于约4.25的混合物中形成金属络合物来制造。 将金属络合物还原至少0.5小时以形成稳定的胶体纳米颗粒。 与较短的还原时间相比，延长的还原时间提高了胶体颗粒的稳定性。 胶体颗粒的稳定性允许形成具有较高浓度金属的胶体。 胶体中金属的浓度优选为至少约150ppm重量。

公开(公告)号：US08883994B2

公开(公告)日：2014-11-11

申请号：US13639843

申请日：2011-03-22

申请人： Kemin Wang ,  Hui Shi ,  Xiaoxiao He ,  Xiaosheng Ye ,  Xu Wu ,  Qiuping Guo ,  Bing Zhou

发明人： Kemin Wang ,  Hui Shi ,  Xiaoxiao He ,  Xiaosheng Ye ,  Xu Wu ,  Qiuping Guo ,  Bing Zhou

IPC分类号： C07H21/02 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  C07H21/00 ,  G01N21/64

CPC分类号： A61K48/0058 ,  A61K49/0054 ,  C12Q1/6818 ,  C12Q1/6886 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/6432 ,  C12Q2525/301 ,  C12Q2525/205

摘要： A switch mode nucleic acid aptamer probe includes a probe main body, a fluorescence generating unit and a fluorescence quenching unit which are respectively connected to two ends of the probe main body. The probe main body includes a nucleic acid aptamer fragment with a function of specifically recognizing target tumor cell and a nucleic acid fragment linked to the nucleic acid aptamer fragment by a connection fragment with a length of 7˜15 nm so as to form a hairpin structure. The ability of competitive hybridization of the nucleic acid fragment with the nucleic acid aptamer fragment is weaker than that of the target tumor cell. The use of the probe of the invention can be at least one of specific detection of tumor living cell in buffer solution, effective detection of tumor living cell in serum, and real-time fluorescence imaging and intravital detection of tumor in living body.

摘要翻译： 开关模式核酸适配体探针包括分别连接到探针主体的两端的探针主体，荧光发生单元和荧光淬灭单元。 探针主体包括具有特异性识别靶肿瘤细胞的功能的核酸适体片段和通过长度为7〜15nm的连接片段与核酸适体片段连接的核酸片段，以形成发夹结构 。 核酸片段与核酸适体片段竞争性杂交的能力弱于目标肿瘤细胞。 使用本发明的探针可以是缓冲溶液中肿瘤活细胞的特异性检测中的至少一种，血清中有效检测肿瘤活细胞，实时荧光成像和活体内肿瘤的活体检测。