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1.发明申请NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂公开(公告)号：US20110081315A1
公开(公告)日：2011-04-07
申请号：US12890475
申请日：2010-09-24
申请人： Brad Buckman , John B. Nicholas , Leonid Beigelman , Vladimir Serebryany , Antitsa Dimitrova Stoycheva , Timothy Thrailkill , Scott Seiwert
发明人： Brad Buckman , John B. Nicholas , Leonid Beigelman , Vladimir Serebryany , Antitsa Dimitrova Stoycheva , Timothy Thrailkill , Scott Seiwert
IPC分类号： A61K38/21 , C07D487/04 , A61K31/437 , A61K31/427 , A61K31/428 , A61K31/5377 , A61K31/445 , A61K31/506 , A61K31/4192 , A61K31/422 , A61K31/4725 , A61K31/522 , A61K31/498 , C12N9/99 , C12N5/02
CPC分类号： C07K5/0812 , A61K31/395 , A61K38/00 , C07K5/0804
摘要： The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I，Ia，II，III，IV，V，VI-1，VI-2，VII，VIII，IX，X，XI和XII的化合物，以及包括药物组合物， 包括主题化合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US08048862B2
公开(公告)日：2011-11-01
申请号：US12423681
申请日：2009-04-14
申请人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
发明人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
IPC分类号： A61K38/21 , A61K31/4709 , A61K31/7056 , A61K31/4738 , A61K31/407 , A61K31/4725 , A61K31/517 , A61K31/403 , C07D245/04 , C07D209/02
CPC分类号： C07D471/04 , A61K31/407 , A61K31/4709 , A61K31/4725 , A61K31/4738 , A61K31/517 , A61K31/7056 , A61K38/212 , A61K38/217 , A61K45/06 , C07D487/04 , C07K5/123 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I，II，III，IV，V，VI，VII和X的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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3.发明申请NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂公开(公告)号：US20110059047A1
公开(公告)日：2011-03-10
申请号：US12949700
申请日：2010-11-18
申请人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
发明人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
CPC分类号： C07D471/04 , A61K31/407 , A61K31/4709 , A61K31/4725 , A61K31/4738 , A61K31/517 , A61K31/7056 , A61K38/212 , A61K38/217 , A61K45/06 , C07D487/04 , C07K5/123 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I，II，III，IV，V，VI，VII和X的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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4.发明申请公开(公告)号：US20090269305A1
公开(公告)日：2009-10-29
申请号：US12423681
申请日：2009-04-14
申请人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
发明人： Scott D. Seiwert , Leonid Beigelman , Brad Buckman , Antitsa Dimitrova Stoycheva , Steven B. Porter , Williamson Ziegler Bradford , Vladimir Serebryany
IPC分类号： A61K38/21 , C07D245/04 , A61K31/4709 , C12N9/99 , A61K31/7056 , A61K31/4738 , A61K31/407 , A61K31/4725 , A61K31/517 , A61P31/14 , A61P1/16
CPC分类号： C07D471/04 , A61K31/407 , A61K31/4709 , A61K31/4725 , A61K31/4738 , A61K31/517 , A61K31/7056 , A61K38/212 , A61K38/217 , A61K45/06 , C07D487/04 , C07K5/123 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I，II，III，IV，V，VI，VII和X的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US20090047246A1
公开(公告)日：2009-02-19
申请号：US12029399
申请日：2008-02-11
申请人： Leonid Beigelman , Brad Buckman , Vladimir Serebryany , Guangyi Wang , Jasenka Matulic-Adamic , Antitsa Dimitrova Stoycheva , Steven W. Andrews , Shawn Maurice Misialek , P.T. Ravi Rajagopalan , Andrew M. Fryer , Indrani Gunawardana , Julia Haas , Lily Huang , Machender R. Madduru , Gan Zhang , Karl Kossen , Scott D. Seiwert , Lawrence M. Blatt
发明人： Leonid Beigelman , Brad Buckman , Vladimir Serebryany , Guangyi Wang , Jasenka Matulic-Adamic , Antitsa Dimitrova Stoycheva , Steven W. Andrews , Shawn Maurice Misialek , P.T. Ravi Rajagopalan , Andrew M. Fryer , Indrani Gunawardana , Julia Haas , Lily Huang , Machender R. Madduru , Gan Zhang , Karl Kossen , Scott D. Seiwert , Lawrence M. Blatt
IPC分类号： A61K38/21 , C07D409/06 , A61K31/405 , A61K31/506 , C07D403/08 , A61K31/404 , C07D209/20 , A61K31/675 , C07F9/572 , A61K31/437 , C07D471/02 , C12N9/99 , A61K31/44 , A61K39/395 , A61K31/427 , C12N9/50 , C12N9/00 , C12Q1/68 , G01N33/53
CPC分类号： C07F9/65583 , C07D209/18 , C07D209/30 , C07D209/32 , C07D307/79 , C07D333/60 , C07D401/10 , C07D403/06 , C07D403/10 , C07D403/12 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/06 , C07D487/04 , C07F9/5728 , C12Q1/707 , G01N2333/186 , G01N2333/914
摘要： The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US20110110890A1
公开(公告)日：2011-05-12
申请号：US12941682
申请日：2010-11-08
IPC分类号： A61K31/549 , C07D471/04 , A61K38/21 , A61K31/7056 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61K31/675 , A61P31/14
CPC分类号： C07D455/02
摘要： The embodiments provide compounds of the general Formula I and compound 105S, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I和化合物105S的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US20110082182A1
公开(公告)日：2011-04-07
申请号：US12894535
申请日：2010-09-30
IPC分类号： A61K31/4184 , C07D403/12 , A61P31/14 , C12N9/99
CPC分类号： C12N9/99 , C07D515/18
摘要： Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, medicaments, and dosage forms related thereto are also disclosed.
摘要翻译： 本文公开了由下式表示的化合物：还公开了与之相关的治疗方法，组合物，药物和剂型。
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公开(公告)号：US20090257979A1
公开(公告)日：2009-10-15
申请号：US12423720
申请日：2009-04-14
IPC分类号： A61K31/5415 , C07D285/22 , C12N9/99 , A61K38/21 , A61P31/18 , A61P31/20
CPC分类号： C07D471/04 , C07D285/30 , C07D417/04 , C07D487/04
摘要： The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US07932277B2
公开(公告)日：2011-04-26
申请号：US12118624
申请日：2008-05-09
申请人： Scott Seiwert , Steven W. Andrews , Leonid Beigelman , Lawrence M. Blatt , Brad Buckman , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timothy S. Kercher , Michael A. Lyon , Bin Wang
发明人： Scott Seiwert , Steven W. Andrews , Leonid Beigelman , Lawrence M. Blatt , Brad Buckman , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timothy S. Kercher , Michael A. Lyon , Bin Wang
IPC分类号： A61K31/4035 , A61K31/428 , A61K31/4025 , A61K31/401 , C07D207/09 , C07D403/12 , C07D417/12
CPC分类号： C07D217/26 , C07D401/12 , C07D417/14
摘要： The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译： 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案提供了通式II的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号：US07728013B2
公开(公告)日：2010-06-01
申请号：US11431132
申请日：2006-05-09
申请人： Lawrence M. Blatt , Scott D. Seiwert , Leonid Beigelman , Ramachandran Radhakrishnan , Karl Kossen , Vladimir Serebryany
发明人： Lawrence M. Blatt , Scott D. Seiwert , Leonid Beigelman , Ramachandran Radhakrishnan , Karl Kossen , Vladimir Serebryany
IPC分类号： A61K31/44 , A01N43/40 , C07D213/62 , C07D213/44
CPC分类号： A61K31/4412 , A61K31/44 , A61K31/444 , A61K31/45 , A61K31/4704 , A61K31/7052 , A61K47/56 , A61K47/58 , C07D213/16 , C07D213/26 , C07D213/63 , C07D213/64 , C07D213/69 , C07D215/227 , C07H15/26 , C07K1/1077 , C08F289/00 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/475
摘要： Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
摘要翻译： 公开了用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制至少一种p38MAPK的能力; 并且其中所述接触以对所述化合物抑制至少一种p38MAPK的低百分比抑制浓度的SAPK-调节浓度进行。 还公开了吡非尼酮的衍生物。 这些衍生物可以调节应激活化蛋白激酶（SAPK）系统。
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