专利检索 ap:("Brian R. Dixon" OR "Cedo M. Bagi" OR "Catherine R. Brennan" OR "David R. Brittelli" OR "William H. Bullock" OR "Jinshan Chen" OR "William L. Collibee" OR "Robert Dally" OR "Jeffrey S. Johnson" OR "Harold C. E. Kluender" OR "William F. Lathrop" OR "Peiying Liu" OR "Carol Ann Mase" OR "Anikó M. Redman" OR "William J. Scott" OR "Klaus Urbahns" OR "Donald J. Wolanin") AND inv:"William H. Bullock" 第 1 页

1.

发明授权
Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents 有权
标题翻译：取代的2-芳基亚氨基杂环和含有它们的组合物，用作孕激素受体结合剂

公开(公告)号：US06353006B1

公开(公告)日：2002-03-05

申请号：US09453613

申请日：1999-12-03

申请人： Brian R. Dixon , Cedo M. Bagi , Catherine R. Brennan , David R. Brittelli , William H. Bullock , Jinshan Chen , William L. Collibee , Robert Dally , Jeffrey S. Johnson , Harold C. E. Kluender , William F. Lathrop , Peiying Liu , Carol Ann Mase , Anikó M. Redman , William J. Scott , Klaus Urbahns , Donald J. Wolanin

发明人： Brian R. Dixon , Cedo M. Bagi , Catherine R. Brennan , David R. Brittelli , William H. Bullock , Jinshan Chen , William L. Collibee , Robert Dally , Jeffrey S. Johnson , Harold C. E. Kluender , William F. Lathrop , Peiying Liu , Carol Ann Mase , Anikó M. Redman , William J. Scott , Klaus Urbahns , Donald J. Wolanin

IPC分类号： A01N4340

CPC分类号： C07D263/28 , C07D263/58 , C07D277/18 , C07D277/60 , C07D279/06 , C07D281/02 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10

摘要： This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

摘要翻译： 本发明涉及2-芳基亚氨基杂环，包括2-芳基亚氨基-1,3-噻唑烷，2-芳基亚氨基-2,3,4,5-四氢-1,3-噻嗪，2-芳基亚氨基-1,3-噻唑烷-2-酮， 4-芳基亚氨基-1,3-噻唑烷-5-酮和2-芳基亚氨基-1,3-恶唑烷，以及它们在调节孕酮受体介导的过程中的用途，以及用于这些疗法的药物组合物。

2.

发明授权
2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译：用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物

公开(公告)号：US06919371B2

公开(公告)日：2005-07-19

申请号：US10666903

申请日：2003-09-17

申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang

发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang

IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352

CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14

摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。

3.

发明授权
2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译：用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物

公开(公告)号：US06660752B2

公开(公告)日：2003-12-09

申请号：US10131448

申请日：2002-04-22

申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang

发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang

IPC分类号： A61K3144

CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14

摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。

4.

发明授权
1,8 Naphthyridine derivatives and their use to treat diabetes and related disorders 失效
标题翻译： 1,8萘啶衍生物及其用于治疗糖尿病和相关疾病的用途

公开(公告)号：US07109196B2

公开(公告)日：2006-09-19

申请号：US10834357

申请日：2004-04-28

申请人： Yamin Wang , William H. Bullock , David E. Gunn , Qingjie Liu , Sidney X. Liang , Donglei Liu , Steven R. Magnuson , Tindy Li , Eric S. Mull , Jill E. Wood , Ning Qi

发明人： Yamin Wang , William H. Bullock , David E. Gunn , Qingjie Liu , Sidney X. Liang , Donglei Liu , Steven R. Magnuson , Tindy Li , Eric S. Mull , Jill E. Wood , Ning Qi

IPC分类号： A61K31/5375 , C07D413/14

CPC分类号： A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00

摘要： The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.

摘要翻译： 本发明一般涉及下式的萘啶衍生物，其中U，X，Y和Z中的一个为氮，其余为C-R，其中R为氢或取代基。更具体地，本发明涉及1,8-萘啶衍生物和含有这些衍生物的药物组合物。本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。

5.

发明申请
INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION 有权

公开(公告)号：US20110152331A1

公开(公告)日：2011-06-23

申请号：US13035638

申请日：2011-02-25

申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston

发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston

IPC分类号： A61K31/421 , C07D263/32 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/00 , A61P35/00

CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12

摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

6.

发明授权
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权

公开(公告)号：US07112597B2

公开(公告)日：2006-09-26

申请号：US10949119

申请日：2004-09-22

申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston

发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston

IPC分类号： A61K31/425 , C07D277/30

CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582

摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

7.

发明授权
1,6-naphthyridine derivatives and their use to treat diabetes and related disorders 失效
标题翻译： 1,6-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途

公开(公告)号：US06964971B2

公开(公告)日：2005-11-15

申请号：US10684299

申请日：2003-10-10

申请人： Yamin Wang , William H. Bullock , Libing Chen

发明人： Yamin Wang , William H. Bullock , Libing Chen

IPC分类号： A61K31/133 , A61K31/155 , A61K31/195 , A61K31/198 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/64 , A61K31/7034 , A61K38/22 , A61K38/28 , A61K45/00 , A61K45/06 , A61P3/04 , A61P3/10 , A61P5/12 , A61P5/42 , A61P9/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/02 , C07D471/04

CPC分类号： A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00

摘要： The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.

摘要翻译： 本发明一般涉及下式的萘啶衍生物，其中U，X，Y和Z中的一个为氮，其余为C-R，其中R为氢或取代基。更具体地，本发明涉及1,6-萘啶衍生物和含有这些衍生物的药物组合物。本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。