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1.发明授权Deposition of discrete nanoparticles on a nanostructured surface of an implant 有权在植入物的纳米结构表面上沉积离散的纳米颗粒公开(公告)号：US07972648B2
公开(公告)日：2011-07-05
申请号：US11977351
申请日：2007-10-24
CPC分类号： A61C8/0015 , A61B17/86 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C13/00 , A61F2/30767 , A61F2002/3084 , A61F2002/30968 , A61F2310/00796 , A61L27/04 , A61L27/10 , A61L27/425 , A61L27/50 , A61L2400/12 , A61L2430/02 , A61L2430/12 , B82Y30/00 , C23C22/02 , C23C24/08 , C23C26/00 , C23C30/00 , C23F1/00
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.
摘要翻译： 公开了一种形成待植入活骨的植入物的方法。 该方法包括使植入物表面的至少一部分粗糙化以产生微观粗糙表面的作用。 该方法还包括在微观粗糙表面上形成纳米尺度的粗糙表面。 该方法还包括通过将粗糙化表面暴露于包括纳米颗粒的溶液的一步法将纳米尺度粗糙化表面上的离散纳米颗粒沉积的行为。 纳米颗粒包含具有促进骨整合性质的材料。
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公开(公告)号：US08486483B2
公开(公告)日：2013-07-16
申请号：US11598614
申请日：2006-11-13
CPC分类号： A61C8/0015 , A61B17/866 , A61C8/0006 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C2008/0046 , A61F2/0077 , A61F2/30767 , A61F2/30771 , A61F2002/30925 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00131 , A61F2310/00796 , A61K6/033 , A61K6/04 , A61L27/06 , A61L27/10 , A61L27/32 , A61L2400/12 , C23C26/00 , C23C30/00 , C23G1/106
摘要： A method of forming a nanocrystalline surface on an implant. The method includes the act of roughening at least a portion of the implant surface to form a roughened surface. The method further includes the act of, without forming an alkoxide on the roughened surface, depositing nanocrystals on the roughened surface. The nanocrystals include a material having a property that promotes osseointegration.
摘要翻译： 在植入物上形成纳米晶体表面的方法。 该方法包括使植入物表面的至少一部分粗糙化以形成粗糙表面的动作。 该方法还包括在粗糙化表面上不形成醇盐的作用，将纳米晶体沉积在粗糙化表面上。 纳米晶体包括具有促进骨整合性质的材料。
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公开(公告)号：US20120288828A1
公开(公告)日：2012-11-15
申请号：US13558037
申请日：2012-07-25
CPC分类号： C23F1/26 , A61C2008/0046 , A61F2/30767 , A61F2/30771 , A61F2/3094 , A61F2002/30925 , A61F2310/00023 , A61L27/06 , A61L27/50 , A61L2400/18 , Y10T29/49567
摘要： A titanium 6 Al/4V alloy is provided with a surface topography that is similar to the Osseotite® surface produced on commercially pure titanium. Native oxide is removed from the Ti 6Al/4V alloy, followed by contacting the metal at ambient temperature with an aqueous hydrochloric acid solution containing a relatively small amount of hydrofluoric acid.
摘要翻译： 钛6 Al / 4V合金具有类似于在商业纯钛上生产的Osseiteite表面的表面形貌。 将天然氧化物从Ti 6Al / 4V合金中除去，然后在环境温度下与含有相对少量氢氟酸的盐酸水溶液接触。
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公开(公告)号：US08251700B2
公开(公告)日：2012-08-28
申请号：US10843916
申请日：2004-05-12
IPC分类号： A61F2/02
CPC分类号： C23F1/26 , A61C2008/0046 , A61F2/30767 , A61F2/30771 , A61F2/3094 , A61F2002/30925 , A61F2310/00023 , A61L27/06 , A61L27/50 , A61L2400/18 , Y10T29/49567
摘要： A titanium 6 A1/4V alloy is provided with a surface topography that is similar to the Osseotite® surface produced on commercially pure titanium. Native oxide is removed from the Ti 6A1/4V alloy, followed by contacting the metal at ambient temperature with an aqueous hydrochloric acid solution containing a relatively small amount of hydrofluoric acid.
摘要翻译： 钛6Al / 4V合金具有与在商业纯钛上生产的Osseiteite表面相似的表面形貌。 将天然氧化物从Ti 6A1 / 4V合金中除去，然后在环境温度下与含有相对少量氢氟酸的盐酸水溶液接触。
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5.发明申请Deposition of Discrete Nanoparticles On A Nanostructured Surface Of An Implant 有权离子纳米颗粒在植入物的纳米结构表面上的沉积公开(公告)号：US20110229856A1
公开(公告)日：2011-09-22
申请号：US13110633
申请日：2011-05-18
IPC分类号： A61C8/00
CPC分类号： A61C8/0015 , A61B17/86 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C13/00 , A61F2/30767 , A61F2002/3084 , A61F2002/30968 , A61F2310/00796 , A61L27/04 , A61L27/10 , A61L27/425 , A61L27/50 , A61L2400/12 , A61L2430/02 , A61L2430/12 , B82Y30/00 , C23C22/02 , C23C24/08 , C23C26/00 , C23C30/00 , C23F1/00
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.
摘要翻译： 公开了一种形成待植入活骨的植入物的方法。 该方法包括使植入物表面的至少一部分粗糙化以产生微观粗糙表面的作用。 该方法还包括在微观粗糙表面上形成纳米尺度的粗糙表面。 该方法还包括通过将粗糙化表面暴露于包括纳米颗粒的溶液的一步法将纳米尺度粗糙化表面上的离散纳米颗粒沉积的行为。 纳米颗粒包含具有促进骨整合性质的材料。
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公开(公告)号：US07771774B2
公开(公告)日：2010-08-10
申请号：US11598610
申请日：2006-11-13
CPC分类号： A61C8/0015 , A61B17/866 , A61C8/0006 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C2008/0046 , A61F2/0077 , A61F2/30767 , A61F2/30771 , A61F2002/30925 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00131 , A61F2310/00796 , A61K6/033 , A61K6/04 , A61L27/06 , A61L27/10 , A61L27/32 , A61L2400/12 , C23C26/00 , C23C30/00 , C23G1/106
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a roughened surface. The method further comprises the act of depositing discrete nanoparticles on the roughened surface though a one-step process of exposing the roughened surface to a solution. The nanoparticles comprise a material having a property that promotes osseointegration.
摘要翻译： 公开了一种形成待植入活骨的植入物的方法。 该方法包括使植入物表面的至少一部分粗糙化以产生粗糙表面的动作。 该方法还包括通过将粗糙表面暴露于溶液的一步法将沉积在粗糙表面上的离散纳米颗粒的行为。 纳米颗粒包含具有促进骨整合性质的材料。
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公开(公告)号：US10227697B2
公开(公告)日：2019-03-12
申请号：US13558037
申请日：2012-07-25
摘要： A titanium 6 A1/4V alloy is provided with a surface topography that is similar to the Osseotite® surface produced on commercially pure titanium. Native oxide is removed from the Ti 6A1/4V alloy, followed by contacting the metal at ambient temperature with an aqueous hydrochloric acid solution containing a relatively small amount of hydrofluoric acid.
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8.发明申请Deposition of discrete nanoparticles on a nanostructured surface of an implant 有权在植入物的纳米结构表面上沉积离散的纳米颗粒公开(公告)号：US20080220394A1
公开(公告)日：2008-09-11
申请号：US11977351
申请日：2007-10-24
CPC分类号： A61C8/0015 , A61B17/86 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C13/00 , A61F2/30767 , A61F2002/3084 , A61F2002/30968 , A61F2310/00796 , A61L27/04 , A61L27/10 , A61L27/425 , A61L27/50 , A61L2400/12 , A61L2430/02 , A61L2430/12 , B82Y30/00 , C23C22/02 , C23C24/08 , C23C26/00 , C23C30/00 , C23F1/00
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.
摘要翻译： 公开了一种形成待植入活骨的植入物的方法。 该方法包括使植入物表面的至少一部分粗糙化以产生微观粗糙表面的作用。 该方法还包括在微观粗糙表面上形成纳米尺度的粗糙表面。 该方法还包括通过将粗糙化表面暴露于包括纳米颗粒的溶液的一步法将纳米尺度粗糙化表面上的离散纳米颗粒沉积的行为。 纳米颗粒包含具有促进骨整合性质的材料。
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公开(公告)号：US08309162B2
公开(公告)日：2012-11-13
申请号：US12359780
申请日：2009-01-26
CPC分类号： A61C8/0013 , A61C8/0012 , A61C8/0022 , A61C8/005 , A61C8/006 , A61K6/0205 , A61K6/04 , A61L27/06 , A61L27/10 , A61L27/306 , A61L27/32 , A61L27/50 , A61L2400/18 , A61L2430/12 , C23F1/30
摘要： A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.
摘要翻译： 增加待植入到活骨中的植入物亲水性的方法。 该方法包括通过将表面暴露于包含无毒盐的溶液而将无毒盐残留物沉积在植入物的表面上的作用。 该方法还包括干燥植入物的动作。
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公开(公告)号：US20110233169A1
公开(公告)日：2011-09-29
申请号：US13074670
申请日：2011-03-29
申请人： Robert L. Mayfield , Ross W. Towse
发明人： Robert L. Mayfield , Ross W. Towse
CPC分类号： A61C8/0015 , A61C8/00 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C8/0037 , A61C13/00 , A61C2008/0046 , A61L27/04 , A61L2400/18 , B82Y30/00 , C23F1/00 , C23F1/26 , C23F1/30 , C23F1/38 , C23G1/106
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises the act of immersing the microscale roughened surface into a solution containing hydrogen peroxide and a basic solution to produce a nanoscale roughened surface consisting of nanopitting superimposed on the microscale roughened surface. The nanoscale roughened surface has a property that promotes osseointegration.
摘要翻译： 公开了一种形成待植入活骨的植入物的方法。 该方法包括使植入物表面的至少一部分粗糙化以产生微观粗糙表面的作用。 该方法还包括将微观粗糙表面浸入含有过氧化氢和碱性溶液的溶液中以产生由叠加在微观粗糙表面上的纳米孔组成的纳米级粗糙表面的行为。 纳米级粗糙表面具有促进骨整合的性质。
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