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公开(公告)号：US08535536B1
公开(公告)日：2013-09-17
申请号：US12830104
申请日：2010-07-02
申请人： Bruce K. Gale , Himanshu Sant , Venu Madhav , Srinivas Merugu
发明人： Bruce K. Gale , Himanshu Sant , Venu Madhav , Srinivas Merugu
IPC分类号： B01D61/28
CPC分类号： B01D57/00 , G01N30/0005 , G01N2030/0035
摘要： A split thin-flow separations device can include a fluid channel having an inlet zone, an outlet zone, and a transport region between the inlet zone and outlet zone. The inlet zone includes a sample inlet and a carrier fluid inlet which are fluidly separated by an inlet splitter to minimize mixing of fluids from respective inlets in the inlet zone. The transport region can be a substantially open channel. Similar to the inlet zone, the outlet zone can include a sample outlet and a carrier outlet which are fluidly separated by an outlet splitter to segregate portions of a fluid into each of the two outlets as the fluid enters the outlet zone. A plurality of cross-flow inducers can also be oriented along a wall of the fluid channel in the transport region. The cross-flow inducers are oriented to form a cross-flow field across the transport region.
摘要翻译： 分流薄流分离装置可以包括具有入口区域，出口区域和入口区域和出口区域之间的输送区域的流体通道。 入口区域包括样品入口和载体流体入口，其通过入口分离器流体分隔，以最小化来自入口区域中相应入口的流体的混合。 运输区域可以是基本上开放的通道。 与入口区类似，出口区可以包括样品出口和载体出口，其通过出口分流器流体分离，以在流体进入出口区时将流体的一部分分离成两个出口中的每一个。 多个横流诱导器也可沿输送区域中的流体通道的壁定向。 横流诱导剂被定向成跨越传输区域形成交叉流场。
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公开(公告)号：US20120247642A1
公开(公告)日：2012-10-04
申请号：US13308231
申请日：2011-11-30
申请人： Daniel A. Bartholomeusz , Ameya Kantak , Sung Lee , Srinivas Merugu , Himanshu Sant , Ronald W. Boutte , Bruce K. Gale , Charles Thomas , Brenda Marie Thomas
发明人： Daniel A. Bartholomeusz , Ameya Kantak , Sung Lee , Srinivas Merugu , Himanshu Sant , Ronald W. Boutte , Bruce K. Gale , Charles Thomas , Brenda Marie Thomas
CPC分类号： B32B38/10 , B26D7/10 , B26D7/2628 , B26F1/24 , B26F1/3806 , B26F2001/3893 , B29C64/141 , B81B2201/058 , B81C99/009 , B81C2201/019 , Y10T83/293 , Y10T83/303
摘要： A method for making a microstructure includes: providing a film (100) on a release liner (110); feeding the film through a cutting plotter (10); cutting the film with a knife blade (34) of the cutting plotter to form a microstructure pattern; peeling the microstructure pattern from the release liner; and transferring the microstructure pattern to a substrate (170). The cutting plotter for making microstructures includes a knife head with a knife blade disposed adjacent a feed mechanism (20), a motor (42) and control system coupled to the knife head for selectively moving the knife head in relation to the film, and the control system and the knife head having an addressable positioning resolution less than approximately 10 μm.
摘要翻译： 制造微结构的方法包括：在剥离衬垫（110）上提供膜（100）; 通过切割机（10）将胶片进给; 用切割机的刀片（34）切割薄膜以形成微结构图案; 从分离衬片剥离微结构图案; 并将微结构图案转移到基板（170）。 用于制造微结构的切割机包括具有邻近进给机构（20）设置的刀片的刀头，马达（42）和耦合到刀头的控制系统，用于相对于薄膜选择性地移动刀头， 控制系统和刀头具有小于约10μm的可寻址定位分辨率。
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3.发明申请公开(公告)号：US20130204275A1
公开(公告)日：2013-08-08
申请号：US13640467
申请日：2011-04-15
申请人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
发明人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/00349 , A61B2017/00477 , A61B2017/00867 , A61B2017/00893 , A61B2017/1103 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device.
摘要翻译： 公开了用于执行血管吻合的方法，装置，装置，组件和试剂盒。 用于血管吻合的装置包括可在至少两种构型之间移动的组织接合部分。 在一些实施例中，组织接合部分不借助移动部分移动，而在其它实施例中，组织接合部分从一个或多个活动翼部延伸。 当处于部署前配置时，组织接合部分可以分开第一距离，并且当处于展开配置时，组织接合部分可以分开第一距离。 一种方法包括将耦合装置的多个组织接合构件抵靠第一端组织接合。 在选择性地接合组织接合构件和第一端部组织之后，通过至少移动组织接合构件来拉伸第一端部组织。 拉伸的第一端组织通过将联接装置配合到配合的吻合装置而联接到第二端组织。
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公开(公告)号：US20120089113A1
公开(公告)日：2012-04-12
申请号：US13211169
申请日：2011-08-16
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device (40) having an active agent reservoir (44) disposed in an annular body (42), the annular body (42) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.
摘要翻译： 用于将活性剂递送到受试者眼睛的装置，系统和方法可以包括具有设置在环形体（42）中的活性剂储存器（44）的眼部活性剂递送装置（40），所述环形体 42）被配置为装配在透镜胶囊内部并且至少部分地环绕眼镜片内的眼内透镜的视线。
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公开(公告)号：US20110282328A1
公开(公告)日：2011-11-17
申请号：US12945428
申请日：2010-11-12
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译： 本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。 在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部， 至少部分地包围晶状体囊内的眼内透镜的视线。 装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。 此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。
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公开(公告)号：US10064819B2
公开(公告)日：2018-09-04
申请号：US13543597
申请日：2012-07-06
IPC分类号： A61M31/00 , A61K9/00 , A61K31/573 , A61K9/20
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.
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公开(公告)号：US09642623B2
公开(公告)日：2017-05-09
申请号：US13640467
申请日：2011-04-15
申请人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
发明人： Jayant P. Agarwal , Bruce K. Gale , Lam Nguyen , Cory Shorr , Brian Stauffer , Cody Lee Gehrke
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/00349 , A61B2017/00477 , A61B2017/00867 , A61B2017/00893 , A61B2017/1103 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device.
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8.发明授权公开(公告)号：US08395468B2
公开(公告)日：2013-03-12
申请号：US12159927
申请日：2007-01-04
IPC分类号： H01F7/02
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383
摘要： A magnetic field generation system includes first (28a) and second (28b) magnetic flux concentrators spaced apart to form a sample volume (30). A first set of auxiliary permanent magnets (10a, 10b) can be symmetrically oriented about and in contact with a portion of the first magnetic flux concentrator (28a). Similarly, a second set of auxiliary permanent magnets (10c, 10d) can be symmetrically oriented about and in contact with a portion of the second magnetic flux concentrator (28b). The first(10a, 10b) and second (10c, 10d) sets of auxiliary magnets can be magnetically associated via the first (28a) and second (28b) magnetic flux concentrators. Magnetically soft shunts (38) can be movably oriented to allow variation of the magnetic field strength across the sample volume by disrupting the field flux across the magnetic flux concentrators.
摘要翻译： 磁场产生系统包括间隔开以形成样品体积（30）的第一（28a）和第二（28b）磁通集中器。 第一组辅助永磁体（10a，10b）可以对称地定向并且与第一磁通集中器（28a）的一部分接触。 类似地，第二组辅助永磁体（10c，10d）可以对称地定向并且与第二磁通集中器（28b）的一部分接触。 第一（10a，10b）和第二（10c，10d）组辅助磁体可以经由第一（28a）和第二（28b）磁通量集中器磁性地相关联。 磁软分流器（38）可以可移动地定向以允许通过扰动磁通量集中器上的磁场通量来改变样品体积上的磁场强度。
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公开(公告)号：US20080187445A1
公开(公告)日：2008-08-07
申请号：US11701976
申请日：2007-02-02
申请人： Bruce K. Gale , Mark A. Eddings
发明人： Bruce K. Gale , Mark A. Eddings
IPC分类号： F04F5/00
CPC分类号： F04B19/006
摘要： The present invention is directed to pumps, device, and methods for handling liquids on a microscale. Specifically, a microfluidic pump is described in which liquid in a fluid microchannel may be moved in either direction due to the diffusion of a gas through a diffusion membrane in response to a pressure differential applied through a control microchannel. This pump can provide non-contact, and optionally, bi-directional movement of liquid in microfluidics platforms, as well as bubble-free filling of dead-end microchannels and reservoirs.
摘要翻译： 本发明涉及用于在微尺度处理液体的泵，装置和方法。 具体地，描述了微流体泵，其中流体微通道中的液体可以由于气体通过扩散膜的扩散而响应于通过控制微通道施加的压力差而在任一方向上移动。 该泵可以提供液体在微流体平台中的非接触和任选的双向运动，以及无端口的死端微通道和储存器的填充。
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公开(公告)号：US09682372B2
公开(公告)日：2017-06-20
申请号：US12487962
申请日：2009-06-19
申请人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
发明人： Bruce K. Gale , Adam Miles , Joshua Wayne Eckman , Sriram Natarajan , Jim Smith , Mark Eddings
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01L2300/0819 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887
摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.
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