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公开(公告)号：US10429384B2
公开(公告)日：2019-10-01
申请号：US13522736
申请日：2011-01-20
IPC分类号： G01N33/53 , G01N33/566 , C07K14/705 , C12Q1/6883
摘要： The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
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2.发明申请Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Metabolic Disorders 审中-公开组合物，试剂盒和鉴别，评估，预防和治疗代谢紊乱的方法公开(公告)号：US20130019326A1
公开(公告)日：2013-01-17
申请号：US13522736
申请日：2011-01-20
IPC分类号： G01N33/566 , C40B30/04 , C07K14/72 , A01K67/027 , C07K16/28 , C12Q1/68 , C12N15/12
CPC分类号： G01N33/566 , C07K14/70567 , C12Q1/6883 , C12Q2600/106 , G01N2333/70567 , G01N2440/14 , G01N2500/04 , G01N2800/04 , G01N2800/52
摘要： The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
摘要翻译： 本发明提供了通过调节PPARγ磷酸化（例如，鼠过氧化物酶体增殖物激活受体γ（PPARγ）2的Ser-273磷酸化）或相应的丝氨酸残基的选择性促进抗代谢紊乱活性的方法和组合物 一种鼠PPARγ2同源物，包括人类）。 还提供了通过选择性抑制这种PPARγ磷酸化来预防，治疗或预测受试者中代谢紊乱疗法的反应性的方法。 还提供了鉴定能够调节这种PPARγ磷酸化的化合物的方法。
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3.发明授权Apparatus for automatically measuring a relatively wide range of leakage currents 失效用于自动测量相对宽范围的漏电流的装置公开(公告)号：US07148674B2
公开(公告)日：2006-12-12
申请号：US10929807
申请日：2004-08-30
申请人： In Hyuk Choi , Dong Il Lee , Jeong Shik Ahn , Gil Jo Jung , Jang Hyun Choi
发明人： In Hyuk Choi , Dong Il Lee , Jeong Shik Ahn , Gil Jo Jung , Jang Hyun Choi
CPC分类号： G01R19/2513 , G01R31/1245
摘要： A leakage current measurement apparatus for measuring leakage currents is disclosed. The leakage current measurement apparatus automatically selects one of non-inductive shunt resistors of 10Ω, 100Ω, and 1000Ω and measures leakage currents of an outdoor isolation material for an ultra-high voltage. Additionally, the leakage current measurement apparatus is capable of measuring a relatively wide range of leakage currents with a relatively high precision, even at a remote location, as a measurement range is automatically adjusted within measurement ranges preset by a user when leakage currents of an outdoor isolation material change, and being protected against a surge possibly generated by an ultra-high voltage. Also, it can remotely measure in real-time leakage currents of an outdoor isolation material installed at a remote location over Ethernet.
摘要翻译： 公开了一种用于测量泄漏电流的泄漏电流测量装置。 泄漏电流测量装置自动选择10mega，100Omega和1000Omega的非感性并联电阻器，并测量超高压室外隔离材料的漏电流。 此外，即使在远程位置，泄漏电流测量装置能够以相对较高的精度测量相对宽的泄漏电流范围，因为在用户在室外的泄漏电流下由用户预设的测量范围内自动调节测量范围 隔离材料变化，并被防止可能由超高电压产生的浪涌。 此外，它可以通过以太网远程测量安装在远程位置的室外隔离材料的实时泄漏电流。
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4.发明授权Method for preparing polymer polyol stabilizer using maleic anhydride, and polymer polyol stabilizer prepared thereby 有权使用马来酸酐制备聚合物多元醇稳定剂的方法，以及由此制备的聚合物多元醇稳定剂公开(公告)号：US07960496B2
公开(公告)日：2011-06-14
申请号：US12000621
申请日：2007-12-14
申请人： Jang Hyun Choi , Seung Moo Huh , Jeon Koo Lee , Jong Yeol Choi
发明人： Jang Hyun Choi , Seung Moo Huh , Jeon Koo Lee , Jong Yeol Choi
IPC分类号： C08G63/58 , C08G63/42 , C08G63/676 , C08G63/78
CPC分类号： C08G18/632 , C08F283/06 , C08G18/4009 , C08G18/409 , C08G18/4829 , C08G18/4845 , C08G18/485 , C08G18/635 , C08G18/636 , C08G18/638 , C08G18/7621 , C08G2101/005 , C08L83/00 , C08F212/10
摘要： Disclosed herein is a novel stabilizer for preparing a polymer polyol, which is used to prepare polyurethane foam having improved physical properties. The stabilizer is prepared by allowing maleic anhydride to react with a polyether polyol, having an OH functionality of 3-8 and a molecular weight of 3,000-15,000, and then adding ethylene oxide to the reaction solution. Because the molecular weight and functionality of the stabilizer are increased through aging and dimerization, the stabilizer has a high molecular weight of 5,000-30,000, a high OH functionality of 6-10 and a viscosity of 3,000-15,000 cps/25° C. A polymer polyol derived from the stabilizer has low viscosity compared to those of prior products and contributes to the improvement in the physical properties of the resulting polyurethane foam.
摘要翻译： 本文公开了一种用于制备聚合物多元醇的新型稳定剂，其用于制备具有改进的物理性能的聚氨酯泡沫。 通过使马来酸酐与OH官能度为3-8，分子量为3,000-15,000的聚醚多元醇反应制备稳定剂，然后向反应溶液中加入环氧乙烷。 由于稳定剂的分子量和官能度通过老化和二聚而增加，稳定剂具有5,000-30,000的高分子量，6-10的高OH官能度和3,000-15,000cps / 25℃的粘度。 衍生自稳定剂的聚合物多元醇与现有产品相比具有低粘度，并且有助于所得聚氨酯泡沫体的物理性能的改善。
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公开(公告)号：US07244511B2
公开(公告)日：2007-07-17
申请号：US11325828
申请日：2006-01-04
申请人： Jang Hyun Choi , Sung Su Jun , Sang Hoon Park , Won Young Lee , Byung Hak Lee
发明人： Jang Hyun Choi , Sung Su Jun , Sang Hoon Park , Won Young Lee , Byung Hak Lee
CPC分类号： C09D175/06 , B05D3/12 , B05D5/061 , B05D7/14 , B05D7/57 , B05D2202/15 , B05D2252/00 , B05D2350/65 , B05D2503/00 , C08G18/42 , C08G18/58 , Y10T428/12396 , Y10T428/12556 , Y10T428/12569 , Y10T428/12799 , Y10T428/12972 , Y10T428/26 , Y10T428/31681
摘要： A single-side embossed color steel sheet, and a method for manufacturing the same are disclosed. The steel sheet comprises a steel sheet substrate, a zinc or zinc alloy-plated layer, a non-chromate or chromate pretreated layer, a primary coat paint layer of modified epoxy or modified polyester, a color base paint layer, a printed layer, and a top coat clear paint layer. The printed layer exhibits a feeling of solidity with various feelings of texture and colors. The top coat clear paint layer serves to protect the printed layer from contaminants. The color steel sheet exhibits a remarkably enhanced feeling of solidity at an irregular surface thereof, and has enhanced contaminant resistance properties and environmental friendliness, thereby satisfying requirements for aesthetic design and functionality of products.
摘要翻译： 公开了一种单面压纹彩色钢板及其制造方法。 钢板包括钢板基材，锌或锌合金镀层，非铬酸盐或铬酸盐预处理层，改性环氧树脂或改性聚酯的初级涂层漆层，色底漆层，印刷层和 顶漆清漆层。 印刷层呈现出各种感觉的纹理和颜色的坚实感。 顶层透明漆层用于保护印刷层免受污染。 彩色钢板在其不规则表面显示出显着增强的坚固感，并且具有增强的耐污染性和环境友好性，从而满足了美学设计和产品功能的要求。
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公开(公告)号：US20110028652A1
公开(公告)日：2011-02-03
申请号：US12903875
申请日：2010-10-13
申请人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
发明人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
IPC分类号： C08L33/12
CPC分类号： C08L51/003 , C08L25/12 , C08L51/04 , C08L2666/06
摘要： Disclosed are a synthetic resin composition for use as building materials such as window frames, as well as a product manufactured using the same. More particularly, the synthetic resin composition comprises a tetrapolymer of acrylic rubber-styrene monomer-butadiene rubber-vinyl cyanide monomer and a styrene-vinyl cyanide copolymer having a high molecular weight and a high degree of dispersion. Unlike products manufactured using prior polyvinyl chloride (PVC), building material such as window frames manufactured using the synthetic resin composition are recyclable, and thus can contribute to a reduction in the generation of hormone-disrupting chemical dioxin, which is released in the burning thereof. Also, the resin composition can be manufactured into products having excellent properties of weather resistance and colorability without using environmental pollutants such as cadmium stearate or lead stearate, which are used as thermal stabilizers.
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7.发明申请Method for preparing polymer polyol stabilizer using maleic anhydride, and polymer polyol stabilizer prepared thereby 有权使用马来酸酐制备聚合物多元醇稳定剂的方法，以及由此制备的聚合物多元醇稳定剂公开(公告)号：US20080287645A1
公开(公告)日：2008-11-20
申请号：US12000621
申请日：2007-12-14
申请人： Jang Hyun Choi , Seung Moo Huh , Jeon Koo Lee , Jong Yeol Choi
发明人： Jang Hyun Choi , Seung Moo Huh , Jeon Koo Lee , Jong Yeol Choi
CPC分类号： C08G18/632 , C08F283/06 , C08G18/4009 , C08G18/409 , C08G18/4829 , C08G18/4845 , C08G18/485 , C08G18/635 , C08G18/636 , C08G18/638 , C08G18/7621 , C08G2101/005 , C08L83/00 , C08F212/10
摘要： Disclosed herein is a novel stabilizer for preparing a polymer polyol, which is used to prepare polyurethane foam having improved physical properties. The stabilizer is prepared by allowing maleic anhydride to react with a polyether polyol, having an OH functionality of 3-8 and a molecular weight of 3,000-15,000, and then adding ethylene oxide to the reaction solution. Because the molecular weight and functionality of the stabilizer are increased through aging and dimerization, the stabilizer has a high molecular weight of 5,000-30,000, a high OH functionality of 6-10 and a viscosity of 3,000-15,000 cps/25° C. A polymer polyol derived from the stabilizer has low viscosity compared to those of prior products and contributes to the improvement in the physical properties of the resulting polyurethane foam.
摘要翻译： 本文公开了一种用于制备聚合物多元醇的新型稳定剂，其用于制备具有改进的物理性能的聚氨酯泡沫。 通过使马来酸酐与OH官能度为3-8，分子量为3,000-15,000的聚醚多元醇反应制备稳定剂，然后向反应溶液中加入环氧乙烷。 由于稳定剂的分子量和官能度通过老化和二聚而增加，稳定剂具有5,000-30,000的高分子量，6-10的高OH官能度和3,000-15,000cps / 25℃的粘度。 衍生自稳定剂的聚合物多元醇与现有产品相比具有低粘度，并且有助于所得聚氨酯泡沫体的物理性能的改善。
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8.发明授权公开(公告)号：US08039533B2
公开(公告)日：2011-10-18
申请号：US12903875
申请日：2010-10-13
申请人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
发明人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
CPC分类号： C08L51/003 , C08L25/12 , C08L51/04 , C08L2666/06
摘要： Disclosed are a synthetic resin composition for use as building materials such as window frames, as well as a product manufactured using the same. More particularly, the synthetic resin composition comprises a tetrapolymer of acrylic rubber-styrene monomer-butadiene rubber-vinyl cyanide monomer and a styrene-vinyl cyanide copolymer having a high molecular weight and a high degree of dispersion. Unlike products manufactured using prior polyvinyl chloride (PVC), building material such as window frames manufactured using the synthetic resin composition are recyclable, and thus can contribute to a reduction in the generation of hormone-disrupting chemical dioxin, which is released in the burning thereof. Also, the resin composition can be manufactured into products having excellent properties of weather resistance and colorability without using environmental pollutants such as cadmium stearate or lead stearate, which are used as thermal stabilizers.
摘要翻译： 公开了一种用作建筑材料如窗框的合成树脂组合物，以及使用该合成树脂组合物制造的产品。 更具体地，合成树脂组合物包含丙烯酸橡胶 - 苯乙烯单体 - 丁二烯橡胶 - 乙烯基氰单体和具有高分子量和高分散度的苯乙烯 - 乙烯基氰共聚物的四元共聚物。 与使用现有的聚氯乙烯（PVC）制造的产品不同，使用合成树脂组合物制造的窗框的建筑材料是可回收的，因此可以有助于减少在其燃烧中释放的激素破坏性化学二恶英的产生 。 此外，树脂组合物可以制造成具有优异的耐候性和着色性的产品，而不使用用作热稳定剂的环境污染物如硬脂酸镉或硬脂酸铅。
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9.发明授权公开(公告)号：US07838579B2
公开(公告)日：2010-11-23
申请号：US11914197
申请日：2006-05-12
申请人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
发明人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
CPC分类号： C08L51/003 , C08L25/12 , C08L51/04 , C08L2666/06
摘要： Disclosed are a synthetic resin composition for use as building materials such as window frames, as well as a product manufactured using the same. More particularly, the synthetic resin composition comprises a tetrapolymer of acrylic rubber-styrene monomer-butadiene rubber-vinyl cyanide monomer and a styrene-vinyl cyanide copolymer having a high molecular weight and a high degree of dispersion. Unlike products manufactured using prior polyvinyl chloride (PVC), building material such as window frames manufactured using the synthetic resin composition are recyclable, and thus can contribute to a reduction in the generation of hormone-disrupting chemical dioxin, which is released in the burning thereof. Also, the resin composition can be manufactured into products having excellent properties of weather resistance and colorability without using environmental pollutants such as cadmium stearate or lead stearate, which are used as thermal stabilizers.
摘要翻译： 公开了一种用作建筑材料如窗框的合成树脂组合物，以及使用其制造的产品。 更具体地，合成树脂组合物包含丙烯酸橡胶 - 苯乙烯单体 - 丁二烯橡胶 - 乙烯基氰单体和具有高分子量和高分散度的苯乙烯 - 乙烯基氰共聚物的四元共聚物。 与使用现有的聚氯乙烯（PVC）制造的产品不同，使用合成树脂组合物制造的窗框的建筑材料是可回收的，因此可以有助于减少在其燃烧中释放的激素破坏性化学二恶英的产生 。 此外，树脂组合物可以制造成具有优异的耐候性和着色性的产品，而不使用用作热稳定剂的环境污染物如硬脂酸镉或硬脂酸铅。
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10.发明申请公开(公告)号：US20090156717A1
公开(公告)日：2009-06-18
申请号：US11914197
申请日：2006-05-12
申请人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
发明人： Jang Hyun Choi , Joo Yub Ho , Seung Kyu Lee , Yun Hwan Kim
CPC分类号： C08L51/003 , C08L25/12 , C08L51/04 , C08L2666/06
摘要： Disclosed are a synthetic resin composition for use as building materials such as window frames, as well as a product manufactured using the same. More particularly, the synthetic resin composition comprises a tetrapolymer of acrylic rubber-styrene monomer-butadiene rubber-vinyl cyanide monomer and a styrene-vinyl cyanide copolymer having a high molecular weight and a high degree of dispersion. Unlike products manufactured using prior polyvinyl chloride (PVC), building material such as window frames manufactured using the synthetic resin composition are recyclable, and thus can contribute to a reduction in the generation of hormone-disrupting chemical dioxin, which is released in the burning thereof. Also, the resin composition can be manufactured into products having excellent properties of weather resistance and colorability without using environmental pollutants such as cadmium stearate or lead stearate, which are used as thermal stabilizers.
摘要翻译： 公开了一种用作建筑材料如窗框的合成树脂组合物，以及使用其制造的产品。 更具体地，合成树脂组合物包含丙烯酸橡胶 - 苯乙烯单体 - 丁二烯橡胶 - 乙烯基氰单体和具有高分子量和高分散度的苯乙烯 - 乙烯基氰共聚物的四元共聚物。 与使用现有的聚氯乙烯（PVC）制造的产品不同，使用合成树脂组合物制造的窗框的建筑材料是可回收的，因此可以有助于减少在其燃烧中释放的激素破坏性化学二恶英的产生 。 此外，树脂组合物可以制造成具有优异的耐候性和着色性的产品，而不使用用作热稳定剂的环境污染物如硬脂酸镉或硬脂酸铅。
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