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公开(公告)号：US20060251629A1
公开(公告)日：2006-11-09
申请号：US11480711
申请日：2006-07-03
申请人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
发明人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
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公开(公告)号：US20050152881A1
公开(公告)日：2005-07-14
申请号：US10793976
申请日：2004-03-05
申请人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
发明人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
CPC分类号： A61L27/48 , A61L27/3604 , A61L27/3608 , A61L27/3683
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译： 本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。 还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。 本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。
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公开(公告)号：US20050152880A1
公开(公告)日：2005-07-14
申请号：US10754310
申请日：2004-01-09
申请人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
发明人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
CPC分类号： A61L27/3683 , A61L27/3604 , A61L27/3608 , A61L27/48
摘要： The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes measured at 25° C. In another aspect, the present invention is directed to a tissue implant comprising a human muscle tissue matrix.
摘要翻译： 本发明涉及一种用于生产适合于植入人体的肌肉组织基质的中间组合物，其包含与含水载体（优选生物相容性酸溶液）组合的切碎的同种异体人肌肉组织，以形成具有 在25℃下测量的粘度范围为1厘沲至20,000厘沲。另一方面，本发明涉及包含人肌肉组织基质的组织植入物。
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公开(公告)号：US20080077252A1
公开(公告)日：2008-03-27
申请号：US11949687
申请日：2007-12-03
申请人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
发明人： C. Mills , John Bianchi , Michael Roberts , David Cheung , Chandrasekaran Nataraj , John Howell
IPC分类号： A61F2/02
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译： 本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。 还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。 本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。
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5.发明申请公开(公告)号：US20060228252A1
公开(公告)日：2006-10-12
申请号：US11254481
申请日：2005-10-19
申请人： C. Mills , John Bianchi , Michael Roberts , Michael Zingaro , Wesley Lewis , Chandrasekaran Nataraj , Benjamin Sanders
发明人： C. Mills , John Bianchi , Michael Roberts , Michael Zingaro , Wesley Lewis , Chandrasekaran Nataraj , Benjamin Sanders
IPC分类号： A61L2/18
CPC分类号： A61F2/08 , A61F2/0077 , A61F2/0095 , A61L2/0088 , A61L27/3662 , A61L27/3687 , A61L2430/10 , A61L2430/40
摘要： The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons, ligaments and meniscus, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
摘要翻译： 本发明涉及包括软组织的植入物领域。 更具体地说，本发明涉及用于治疗包括软组织例如腱，韧带和半月板的植入物的方法以及由这些方法产生的植入物。 本发明还涉及用于通过在治疗过程中对植入物或植入物的特定部位施加运动学约束，优选张力，以及通过这些方法和装置产生的植入物来改进包括软组织的植入物的处理的方法和装置 。 本技术产生具有优异的结构，机械和/或生物化学完整性的软组织植入物。
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公开(公告)号：US20050229323A1
公开(公告)日：2005-10-20
申请号：US10828653
申请日：2004-04-20
申请人： C. Mills , John Bianchi , Michael Roberts , Michael Zingaro , Wesley Lewis , Chandrasekaran Nataraj , Benjamin Sanders
发明人： C. Mills , John Bianchi , Michael Roberts , Michael Zingaro , Wesley Lewis , Chandrasekaran Nataraj , Benjamin Sanders
CPC分类号： A61L2/0088 , A61F2/0077 , A61F2/08 , A61L27/50
摘要： The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
摘要翻译： 本发明涉及包括软组织的植入物领域。 更具体地，本发明涉及用于治疗包括软组织如腱和韧带的植入物以及由这些过程产生的植入物的方法。 本发明还涉及用于通过在治疗过程中对植入物或植入物的特定部位施加运动学约束，优选张力，以及通过这些方法和装置产生的植入物来改进包括软组织的植入物的处理的方法和装置 。 本技术产生具有优异的结构，机械和/或生物化学完整性的软组织植入物。
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公开(公告)号：US07648676B2
公开(公告)日：2010-01-19
申请号：US10828653
申请日：2004-04-20
CPC分类号： A61L2/0088 , A61F2/0077 , A61F2/08 , A61L27/50
摘要： The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
摘要翻译： 本发明涉及包括软组织的植入物领域。 更具体地，本发明涉及用于治疗包括软组织如腱和韧带的植入物以及由这些过程产生的植入物的方法。 本发明还涉及用于通过在治疗过程中对植入物或植入物的特定部位施加运动学约束，优选张力，以及通过这些方法和装置产生的植入物来改进包括软组织的植入物的处理的方法和装置 。 本技术产生具有优异的结构，机械和/或生物化学完整性的软组织植入物。
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公开(公告)号：US20130149356A1
公开(公告)日：2013-06-13
申请号：US13815184
申请日：2013-02-07
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译： 本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。 还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。 本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。
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9.发明授权公开(公告)号：US09272004B2
公开(公告)日：2016-03-01
申请号：US12827896
申请日：2010-06-30
IPC分类号： A61F2/00 , A61K9/14 , C07K1/00 , A61K35/32 , A61K35/34 , A61K35/36 , A61L17/08 , A61L27/36 , A61K31/70 , A61F2/28 , A61F2/30
CPC分类号： A61K35/32 , A61F2/28 , A61F2/30756 , A61F2002/2817 , A61F2002/30677 , A61F2002/30766 , A61F2310/00359 , A61F2310/00365 , A61K35/34 , A61K35/36 , A61L17/08 , A61L27/3683
摘要： Bioimplants and methods of making the bioimplants are provided. The bioimplants comprise biological tissues having conjugated thereto adjunct molecules. The biological tissues are sterilized with a chemical sterilizing agent, such as a water soluble carbodiimide. The processes of making the bioimplants include a process in which an adjunct molecule is conjugated to a biological tissue during the sterilization process.
摘要翻译： 提供生物植入物和制备生物体的方法。 生物植入物包括具有缀合于其附属分子的生物组织。 生物组织用化学杀菌剂如水溶性碳二亚胺灭菌。 制备生物植入物的方法包括在灭菌过程中附加分子与生物组织缀合的过程。
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公开(公告)号：US07883541B2
公开(公告)日：2011-02-08
申请号：US11949687
申请日：2007-12-03
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译： 本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。 还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。 本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。
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