公开(公告)号：US20180274020A1

公开(公告)日：2018-09-27

申请号：US15524449

申请日：2015-11-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SLIPCHIP CORPORATION

Inventor： Rustem F. ISMAGILOV ,  Eugenia KHOROSHEVA ,  Travis S. SCHLAPPI ,  Matthew S. CURTIS ,  Nathan G. SCHOEPP ,  Hedia MAAMAR ,  Feng SHEN ,  Erik B. JUE

IPC: C12Q1/6851 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q1/18 ,  B01L7/00 ,  B01L3/00

CPC classification number: C12Q1/6851 ,  B01L3/502715 ,  B01L7/00 ,  B01L2300/0861 ,  C12Q1/18 ,  C12Q1/6809 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2537/165 ,  C12Q2545/114 ,  C12Q2565/629

Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

公开(公告)号：US20240011021A1

公开(公告)日：2024-01-11

申请号：US18173735

申请日：2023-02-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Matthew S. CURTIS ,  Mary ARRASTIA ,  David A. SELCK ,  Mitchell GUTTMAN

IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  C12Q1/6806

CPC classification number: C12N15/1065 ,  B01L3/502715 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  C12Q1/6806 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/161 ,  B01L2300/0861 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2400/065 ,  C40B30/04

Abstract: Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.

公开(公告)号：US20190144854A1

公开(公告)日：2019-05-16

申请号：US16141901

申请日：2018-09-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Matthew S. CURTIS ,  Mary ARRASTIA ,  David A. SELCK ,  Mitchell GUTTMAN

IPC: C12N15/10

Abstract: Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.

公开(公告)号：US20230212661A1

公开(公告)日：2023-07-06

申请号：US17861077

申请日：2022-07-08

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Bing SUN ,  Jesus RODRIGUEZ MANZANO ,  Eugenia KHOROSHEVA ,  Matthew S. CURTIS

IPC: C12Q1/6844 ,  C12Q1/70

CPC classification number: C12Q1/6844 ,  C12Q1/70

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.

公开(公告)号：US20190352705A1

公开(公告)日：2019-11-21

申请号：US16224617

申请日：2018-12-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Bing SUN ,  Jesus RODRIGUEZ MANZANO ,  Eugenia KHOROSHEVA ,  Matthew S. CURTIS

IPC: C12Q1/6848 ,  C12Q1/70 ,  C12Q1/6865 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q1/686

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.

公开(公告)号：US20170152553A1

公开(公告)日：2017-06-01

申请号：US15030202

申请日：2014-10-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Bing SUN ,  Jesus RODRIGUEZ MANZANO ,  Eugenia KHOROSHEVA ,  Matthew S. CURTIS

IPC: C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6865 ,  C12Q1/707 ,  C12Q2527/125 ,  C12Q2565/501 ,  C12Q2531/119 ,  C12Q2565/629

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.