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公开(公告)号：US20160263577A1
公开(公告)日：2016-09-15
申请号：US15022879
申请日：2014-09-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP CORPORATION
Inventor： Rustem F. ISMAGILOV , Feng SHEN , Liang LI , David SELCK , Joe BAKER , Espir KAHATT , Chris DA COSTA
CPC classification number: B01L3/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/523 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/047 , B01L2300/0672 , B01L2300/069 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/161 , B01L2300/1855 , B01L2300/1877 , B01L2400/0409 , B01L2400/043 , B01L2400/0457 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0493 , B01L2400/0644 , B01L2400/0677 , B01L2400/0683 , G01N1/4077
Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
Abstract translation: 本发明涉及用于控制一种或多种流体和/或一种或多种试剂的流体系统。 这些系统可以与用于测定，处理和/或存储样品的一个或多个装置组合使用。 特别地，系统和相关方法可以允许以受控的方式分配流体和/或在实施测定或过程时引入暂停。
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公开(公告)号：US20180274020A1
公开(公告)日：2018-09-27
申请号：US15524449
申请日：2015-11-05
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP CORPORATION
Inventor： Rustem F. ISMAGILOV , Eugenia KHOROSHEVA , Travis S. SCHLAPPI , Matthew S. CURTIS , Nathan G. SCHOEPP , Hedia MAAMAR , Feng SHEN , Erik B. JUE
CPC classification number: C12Q1/6851 , B01L3/502715 , B01L7/00 , B01L2300/0861 , C12Q1/18 , C12Q1/6809 , C12Q1/686 , C12Q1/689 , C12Q2600/136 , C12Q2600/158 , C12Q2537/165 , C12Q2545/114 , C12Q2565/629
Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.
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公开(公告)号：US20230272466A1
公开(公告)日：2023-08-31
申请号：US17863183
申请日：2022-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Jacob T. BARLOW , Said R. BOGATYREV
IPC: C12Q1/686 , C12Q1/6888
CPC classification number: C12Q1/686 , C12Q1/6888
Abstract: Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure.
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公开(公告)号：US20190336969A1
公开(公告)日：2019-11-07
申请号：US16367036
申请日：2019-03-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , University of Chicago
Inventor： Rustem F. ISMAGILOV , Liang MA , Qichao PAN , Mikhail KARYMOV , Toan HUYNH , George SAWICKI , Stefano BEGOLO , Wenbin DU
Abstract: Provided herein are methods, compositions, and devices for the parallel handling of samples, such as cells or other biological samples. The methods, compositions, and devices are suited for multiple levels of analysis, including genetic and functional assays, of samples.
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公开(公告)号：US20190218497A1
公开(公告)日：2019-07-18
申请号：US16236248
申请日：2018-12-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： James Q. BOEDICKER , Rustem F. ISMAGILOV , Hyun Jung KIM
IPC: C12M1/42 , G01N33/543 , G01N33/542 , C12Q1/18 , C12P39/00 , C12M1/14 , C12N1/38 , C12M1/12 , C12M1/00 , C12N1/20 , C12N11/04
CPC classification number: C12M35/08 , C12M1/14 , C12M23/34 , C12M25/01 , C12N1/20 , C12N1/38 , C12N11/04 , C12P39/00 , C12Q1/18 , G01N33/542 , G01N33/54313
Abstract: Provided herein are devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170225161A1
公开(公告)日：2017-08-10
申请号：US15504283
申请日：2015-08-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Stefano BEGOLO , Dmitriy V. ZHUKOV , Daan WITTERS , Erik B. JUE , Rustem F. ISMAGILOV
CPC classification number: B01L3/50273 , B01L3/502715 , B01L3/502746 , B01L3/502776 , B01L3/502784 , B01L2200/025 , B01L2300/041 , B01L2300/046 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/14 , B01L2400/0475 , B01L2400/0478 , B01L2400/0487 , C12Q1/686
Abstract: Provided herein are devices and methods for generating positive and negative pressures. The devices and methods are suited for the generation of pressures; in particular, the pressures generated can be useful for controlling the flow of fluids, such as in fluidic device.
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公开(公告)号：US20210301326A1
公开(公告)日：2021-09-30
申请号：US17164674
申请日：2021-02-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Nathan G. SCHOEPP , Emily S. SAVELA , Eric J. LIAW , Alexander WINNETT , Matthew M. COOPER
IPC: C12Q1/689
Abstract: Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample.
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8.发明申请公开(公告)号：US20190194726A1
公开(公告)日：2019-06-27
申请号：US16158233
申请日：2018-10-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Emily S. SAVELA , Nathan SCHOEPP , Eric J. LIAW
IPC: C12Q1/689
CPC classification number: C12Q1/689 , C12Q1/6806 , C12Q2527/125 , C12Q2533/101 , C12Q2535/122
Abstract: Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample.
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9.发明申请公开(公告)号：US20170189444A1
公开(公告)日：2017-07-06
申请号：US15399711
申请日：2017-01-05
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Sujit S. DATTA , Asher Preska STEINBERG , Said R. BOGATYREV
IPC: A61K31/765
CPC classification number: A61K31/765 , A61K9/0031 , A61K9/0036 , A61K31/716 , A61K31/719 , A61K31/732 , A61K31/77 , A61K35/747 , A61K45/06 , A61K2300/00
Abstract: Polymeric composition and related methods and systems for regulating the structure of hydrogels are described. In particular, by varying the physiochemical properties of the polymeric composition, the structure of the hydrogels can be reversibly compressed or decompressed.
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公开(公告)号：US20220008918A1
公开(公告)日：2022-01-13
申请号：US16316193
申请日：2017-07-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Travis S. SCHLAPPI , Stephanie E. MCCALLA , Nathan G. SCHOEPP
Abstract: Methods and devices for detecting a low concentration analyte in a sample are provided herein. The methods include flowing a sample through a porous membrane coated with a capture matrix to capture the low concentration analyte. The methods also can include detecting the captured analyte, such as by performing in-situ amplification of the analyte.
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