公开(公告)号：US20230310493A1

公开(公告)日：2023-10-05

申请号：US18320417

申请日：2023-05-19

Applicant: CYTOSORBENTS CORPORATION

Inventor： Andreas Viktor SIMM ,  Jorg SCHEIER ,  Christian STEINER ,  Vincent CAPPONI ,  Phillip P. CHAN

IPC: A61K31/79 ,  A61K31/717 ,  A61K31/78

CPC classification number: A61K31/79 ,  A61K31/717 ,  A61K31/78

Abstract: The invention concerns removing advanced glycation end products from a bodily fluid by contacting the bodily fluid with a sorbent.

公开(公告)号：US20190060545A1

公开(公告)日：2019-02-28

申请号：US16082376

申请日：2017-02-17

Applicant: CYTOSORBENTS CORPORATION

Inventor： Maryann GRUDA ,  Pamela O'SULLIVAN ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：US20210106743A1

公开(公告)日：2021-04-15

申请号：US16497982

申请日：2018-03-22

Applicant: CYTOSORBENTS CORPORATION

Inventor： Wei-Tai YOUNG ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Josh VICHARE ,  Timothy KOVACS ,  Maryann GRUDA ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：US20200254170A1

公开(公告)日：2020-08-13

申请号：US16639371

申请日：2018-08-21

Applicant: Vincent CAPPONI ,  Paul ROBERTSON ,  CytoSorbents Corporation

Inventor： Vincent CAPPONI ,  Paul ROBERTSON

IPC: A61M1/34 ,  A61M1/36

Abstract: The invention relates to a removable cap for a blood filter cartridge useful in facilitating dispersal of whole blood in the cartridge. The cartridge has a removable cap on at least one and preferably both of its input and output ends. The caps comprise an annular flange means having attached thereto an outer annular wall and an annular inner wall. The annular inner wall defining a cavity covered by a conical, concave filter mesh. The end cap also comprises a channel means positioned under the cavity and a part of said flange means, for reception of any fluid which passes through said concave filter mesh.

公开(公告)号：US20190201867A1

公开(公告)日：2019-07-04

申请号：US16303232

申请日：2017-05-18

Applicant: CYTOSORBENTS CORPORATION

Inventor： Tamaz GULIASHVILI ,  Thomas GOLOBISH ,  Maryann GRUDA ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vincent CAPPONI ,  Phillip CHAN ,  Wei-Tai YOUNG

IPC: B01J20/26 ,  B01D15/34 ,  A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/125 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US20180303870A1

公开(公告)日：2018-10-25

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas GOLOBISH ,  Maryann GRUDA ,  Tamaz GULIASHVILI ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vi DAN ,  Wei-Tai YOUNG ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M1/3679 ,  A61M5/14 ,  A61M5/165

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.