公开(公告)号：US20200276381A1

公开(公告)日：2020-09-03

申请号：US16645965

申请日：2018-09-13

Applicant: CYTOSORBENTS CORPORATION

Inventor： Dominik GUTZLER ,  Wei-Tai YOUNG

IPC: A61M1/36 ,  A61M39/28 ,  A61M39/24 ,  A61M1/16

Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.

公开(公告)号：US20210106743A1

公开(公告)日：2021-04-15

申请号：US16497982

申请日：2018-03-22

Applicant: CYTOSORBENTS CORPORATION

Inventor： Wei-Tai YOUNG ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Josh VICHARE ,  Timothy KOVACS ,  Maryann GRUDA ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：US20190201867A1

公开(公告)日：2019-07-04

申请号：US16303232

申请日：2017-05-18

Applicant: CYTOSORBENTS CORPORATION

Inventor： Tamaz GULIASHVILI ,  Thomas GOLOBISH ,  Maryann GRUDA ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vincent CAPPONI ,  Phillip CHAN ,  Wei-Tai YOUNG

IPC: B01J20/26 ,  B01D15/34 ,  A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/125 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US20180303870A1

公开(公告)日：2018-10-25

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas GOLOBISH ,  Maryann GRUDA ,  Tamaz GULIASHVILI ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vi DAN ,  Wei-Tai YOUNG ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M1/3679 ,  A61M5/14 ,  A61M5/165

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US20170216345A1

公开(公告)日：2017-08-03

申请号：US15515328

申请日：2015-10-02

Applicant: CYTOSORBENTS CORPORATION

Inventor： Humayra Begum ALI ,  Thomas D. GOLOBISH ,  Vincent J. CAPPONI ,  Phillip P. CHAN ,  Wei-Tai YOUNG ,  Andrew Robert SCHEIRER

IPC: A61K31/765 ,  A61K9/00

CPC classification number: A61K31/765 ,  A61K9/0053 ,  A61K31/75 ,  A61K31/79 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06

Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).