公开(公告)号：US10526429B2

公开(公告)日：2020-01-07

申请号：US15914409

申请日：2018-03-07

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  Patrick Willoughby ,  Niraj Gurung

IPC: C08F8/06 ,  C08F8/42

Abstract: A method for making a polyisobutylene diol from a polyisobutylene diallyl. The method includes hydroborating the polyisobutylene diallyl to produce a polyisobutylene dialkyl borane, and oxidizing the polyisobutylene dialkyl borane to form the polyisobutylene diol. The polyisobutylene diallyl is hydroborated by combining in situ the polyisobutylene diallyl with a borane-coordinating solvent, an alkaline metal salt of borohydride, and an acid. The alkaline metal salt of borohydride is combined with the polyisobutylene diallyl before the acid is combined with the polyisobutylene diallyl.

公开(公告)号：US20190218334A1

公开(公告)日：2019-07-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/62 ,  C08G18/48 ,  C08G18/40 ,  C08G18/76 ,  A61L31/12 ,  A61L31/14

CPC classification number: C08G18/6208 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  A61L31/129 ,  A61L31/143 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/4063 ,  C08G18/4808 ,  C08G18/4854 ,  C08G18/6204 ,  C08G18/7671 ,  C08G18/833 ,  C08G18/3206 ,  C08L53/00

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US10111986B2

公开(公告)日：2018-10-30

申请号：US15293583

申请日：2016-10-14

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Niraj Gurung ,  David R. Wulfman ,  Adegbola O. Adenusi ,  Patrick Willoughby ,  Adeniyi O. Aremu

IPC: A61L31/06 ,  A61L31/10 ,  A61N1/05 ,  C08G81/02 ,  A61L29/08 ,  C08G18/66 ,  C08G18/76 ,  C08G18/12 ,  C08G18/24 ,  C08G18/32

Abstract: A method for making a device including a polyisobutylene-polyurethane block copolymer. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender within a solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

公开(公告)号：US20170174845A1

公开(公告)日：2017-06-22

申请号：US15382254

申请日：2016-12-16

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Niraj Gurung ,  Patrick Willoughby ,  David R. Wulfman ,  Adegbola O. Adenusi ,  Adeniyi O. Aremu

IPC: C08G81/02 ,  A61L29/06

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer and a tertiary amine catalyst. The polyisobutylene-polyurethane block copolymer includes soft segments including at least one polyisobutylene diol residue, and hard segments including at least one diisocyanate residue. The polymeric material is free of an organometallic catalyst.

公开(公告)号：US20170106124A1

公开(公告)日：2017-04-20

申请号：US15293583

申请日：2016-10-14

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  Niraj Gurung ,  David R. Wulfman ,  Adegbola O. Adenusi ,  Patrick Willoughby ,  Adeniyi O. Aremu

IPC: A61L31/06 ,  A61L31/10 ,  A61N1/05 ,  C08G81/02

CPC classification number: A61L31/06 ,  A61L29/085 ,  A61L31/10 ,  A61L2420/02 ,  A61N1/05 ,  A61N1/0507 ,  A61N1/0534 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/056 ,  C08G18/12 ,  C08G18/24 ,  C08G18/3206 ,  C08G18/6674 ,  C08G18/7671 ,  C08G81/024 ,  C08L23/22 ,  C08L75/04 ,  C08L53/00

Abstract: A method for making a device including a polyisobutylene-polyurethane block copolymer. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender within a solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

公开(公告)号：US11851522B2

公开(公告)日：2023-12-26

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/12 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

CPC classification number: C08G18/6208 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  A61L31/129 ,  A61L31/143 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/4063 ,  C08G18/4808 ,  C08G18/4854 ,  C08G18/6204 ,  C08G18/7671 ,  C08G18/833 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/12 ,  C08G18/2865 ,  A61L27/16 ,  C08L53/00 ,  A61L31/048 ,  C08L53/00 ,  A61L29/041 ,  C08L53/00

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US20230018482A1

公开(公告)日：2023-01-19

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  C08G18/28 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US11472911B2

公开(公告)日：2022-10-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US20180258196A1

公开(公告)日：2018-09-13

申请号：US15914409

申请日：2018-03-07

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  Andrew J. Ro ,  Patrick Willoughby ,  Niraj Gurung

IPC: C08F8/06 ,  C08F8/42

Abstract: A method for making a polyisobutylene diol from a polyisobutylene diallyl. The method includes hydroborating the polyisobutylene diallyl to produce a polyisobutylene dialkyl borane, and oxidizing the polyisobutylene dialkyl borane to form the polyisobutylene diol. The polyisobutylene diallyl is hydroborated by combining in situ the polyisobutylene diallyl with a borane-coordinating solvent, an alkaline metal salt of borohydride, and an acid. The alkaline metal salt of borohydride is combined with the polyisobutylene diallyl before the acid is combined with the polyisobutylene diallyl.