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    Peptides derived from endothelial cell growth factor
    1.
    发明授权
    Peptides derived from endothelial cell growth factor 失效
    源自内皮细胞生长因子的肽

    公开(公告)号：US5756686A

    公开(公告)日：1998-05-26

    申请号：US192757

    申请日：1991-11-15

    申请人： Carl-Henrik Heldin ,  Kohei Miyazono ,  Christer Wernstedt ,  Ulf Hellman ,  Fumimaro Takaku ,  Fuyuki Ishikawa

    发明人： Carl-Henrik Heldin ,  Kohei Miyazono ,  Christer Wernstedt ,  Ulf Hellman ,  Fumimaro Takaku ,  Fuyuki Ishikawa

    IPC分类号： C07K14/475 ,  C07K16/22 ,  C12N15/18

    CPC分类号： C07K14/475 ,  C07K16/22

    摘要： Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa endothelial cell mitogen that has been purified to homogeneity from human platelets. It does not bind to heparin and does not stimulate the proliferation of fibroblasts, in contrast to other endothelial mitogens of the fibroblast growth factor (FGF) family. PD-ECGF appears to be the only endothelial cell growth factor in human platelets and recent data indicate that it has angiogenic activity in vitro, i.e., the ability to stimulate the formation of new blood vessels and chemotactic activity, in vitro. The present invention provides a homogeneous PD-ECGF in substantially greater yields than available in the past, the primary structure of PD-ECGF, antibodies against PD-ECGF, clones of its cDNA, and variants thereof. The invention also provides a therapeutic preparation of PD-ECGF.

    摘要翻译： 血小板衍生的内皮细胞生长因子（PD-ECGF）是一种45kDa的内皮细胞丝裂原，其已从人血小板纯化至均质。 与成纤维细胞生长因子（FGF）家族的其他内皮细胞分裂素相反，它不结合肝素并且不刺激成纤维细胞的增殖。 PD-ECGF似乎是人血小板中唯一的内皮细胞生长因子，最近的数据表明它在体外具有血管生成活性，即在体外刺激新血管形成和趋化活性的能力。 本发明提供了基本上比过去可获得的产量大得多的PD-ECGF，PD-ECGF的一级结构，针对PD-ECGF的抗体，其cDNA的克隆及其变体。 本发明还提供PD-ECGF的治疗制剂。

    DNA encoding platelet derived endothelial cell growth factor (PD-ECGF)
    2.
    发明授权
    DNA encoding platelet derived endothelial cell growth factor (PD-ECGF) 失效
    编码血小板衍生的内皮细胞生长因子（PD-ECGF）的DNA

    公开(公告)号：US5227302A

    公开(公告)日：1993-07-13

    申请号：US742092

    申请日：1991-08-02

    申请人： Carl-Henrik Heldin ,  Kohei Miyazono ,  Christer Wernstedt ,  Ulf G. T. Hellman ,  Fumimaro Takaku ,  Fuyuki Ishikawa

    发明人： Carl-Henrik Heldin ,  Kohei Miyazono ,  Christer Wernstedt ,  Ulf G. T. Hellman ,  Fumimaro Takaku ,  Fuyuki Ishikawa

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C07K16/22 ,  C12N15/18

    CPC分类号： C07K14/475 ,  C07K16/22 ,  A61K38/00

    摘要： Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa endothelial cell mitogen that has been purified to homogeneity from human platelets. It does not bind to heparin and does not stimulate the proliferation of fibroblasts, in contrast to other endothelial mitogens of the fibroblast growth factor (FGF) family. PD-ECGF appears to be the only endothelial cell growth factor in human platelets and recent data indicate that it has angiogenic activity in vitro, i.e., the ability to stimulate the formation of new blood vessels and chemotactic activity, in vitro. The present invention provides a homogeneous PD-ECGF in substantially greater yields than available in the past, the primary structure of PD-ECGF, antibodies against PD-ECGF, clones of its cDNA, and variants thereof. The invention also provides a therapeutic preparation of PD-ECGF.

    摘要翻译： 血小板衍生的内皮细胞生长因子（PD-ECGF）是一种45kDa的内皮细胞丝裂原，其已从人血小板纯化至均质。 与成纤维细胞生长因子（FGF）家族的其他内皮细胞分裂素相反，它不结合肝素并且不刺激成纤维细胞的增殖。 PD-ECGF似乎是人血小板中唯一的内皮细胞生长因子，最近的数据表明它在体外具有血管生成活性，即在体外刺激新血管形成和趋化活性的能力。 本发明提供了基本上比过去可获得的产量大得多的PD-ECGF，PD-ECGF的一级结构，针对PD-ECGF的抗体，其cDNA的克隆及其变体。 本发明还提供PD-ECGF的治疗制剂。