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1.发明授权公开(公告)号：US08679741B2
公开(公告)日：2014-03-25
申请号：US12301985
申请日：2007-05-30
IPC分类号： C12Q1/48
CPC分类号： C12N15/1006 , C12N15/1003 , C12N15/1013 , C12Q1/6806 , C12Q1/686
摘要： Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).
摘要翻译： 本文提供了通过物理分离或扩增短碱基对核酸在基因组材料（例如宿主或母体核酸）的高背景存在下提取和相对富集的方法，组合物和试剂盒。
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2.发明申请公开(公告)号：US20100297710A1
公开(公告)日：2010-11-25
申请号：US12301985
申请日：2007-05-30
CPC分类号： C12N15/1006 , C12N15/1003 , C12N15/1013 , C12Q1/6806 , C12Q1/686
摘要： Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).
摘要翻译： 本文提供了通过物理分离或扩增短碱基对核酸在基因组材料（例如宿主或母体核酸）的高背景的存在下提取和相对富集的方法，组合物和试剂盒。
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公开(公告)号：US20090258344A1
公开(公告)日：2009-10-15
申请号：US11570427
申请日：2004-05-27
申请人： Richard B. Roth , Matthew Roberts Nelson , Andreas Braun , Stefan M. Kammerer , Mikhail F. Denissenko , Rikard Reneland , Caridad Rosette , Carolyn R. Hoyal-Wrightson
发明人： Richard B. Roth , Matthew Roberts Nelson , Andreas Braun , Stefan M. Kammerer , Mikhail F. Denissenko , Rikard Reneland , Caridad Rosette , Carolyn R. Hoyal-Wrightson
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
摘要翻译： 本文提供了用于鉴定受试者和/或患有乳腺癌风险的受试者的乳腺癌风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于治疗乳腺癌的候选治疗剂的方法，以及用于治疗乳腺癌的治疗方法 在一个主题 这些实施方案基于对人类基因组内核苷酸序列的多态变异的分析。
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公开(公告)号：US20090305284A1
公开(公告)日：2009-12-10
申请号：US12479478
申请日：2009-06-05
申请人： Richard R. Roth , Andreas Braun , Stefan M. Kammerer , Matthew Roberts Nelson , Rikard Henry Reneland , Carolyn R. Hoyal-Wrightson
发明人： Richard R. Roth , Andreas Braun , Stefan M. Kammerer , Matthew Roberts Nelson , Rikard Henry Reneland , Carolyn R. Hoyal-Wrightson
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
摘要翻译： 本文提供了用于鉴定受试者和/或患有乳腺癌风险的受试者的乳腺癌风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于治疗乳腺癌的候选治疗剂的方法，以及用于治疗乳腺癌的治疗方法 在一个主题 这些实施方案基于对人类基因组内核苷酸序列的多态变异的分析。
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公开(公告)号：US10708199B2
公开(公告)日：2020-07-07
申请号：US16055864
申请日：2018-08-06
IPC分类号： H04J3/22 , H04L12/939 , H04L12/861 , H04L12/947 , H04L12/721 , H04L12/851 , H04L12/54 , H04L12/801 , H04L12/835 , H04L12/70
摘要： Deadlocks in a heterogeneous packet-based transport system are avoided. When receiving a plurality of packets from a root complex where contents of each packet from the plurality of packets organized in accordance with a first protocol, a sequence number is added to each packet and a packet type is identified. Every packet in the first plurality of packets is encapsulated into at least one packet organized in accordance with a second protocol to form a second plurality of packets organized in accordance with the second protocol. All the packets from the second plurality of packets are sent via a plurality of connections so that each connection from the plurality of connections only transports packets from the second plurality of packets that encapsulate packets from the first plurality that have a same packet type.
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公开(公告)号：US10414193B2
公开(公告)日：2019-09-17
申请号：US13579449
申请日：2011-02-23
申请人： Josef Riedl , Andreas Braun
发明人： Josef Riedl , Andreas Braun
IPC分类号： B32B27/08 , B42D25/305 , B42D25/45 , B32B7/02 , B32B27/36 , B32B27/40 , B29D7/01 , B42D25/00 , B32B7/10 , B32B27/18 , B32B27/28 , B29C48/30 , B29C48/08 , B29C48/21 , B29C48/305 , B29K21/00 , B29K67/00 , B29K69/00 , B29K105/00 , B29L17/00 , B29C48/15 , B29C48/49
摘要： A foil composite material usable as a layer in a card body of a portable data carrier, that includes one outer plastic layer, one inner plastic layer and one second outer plastic layer. All the layers jointly form a coextruded composite, and the plastic of one outer layer is a thermoplastic polymer or a mixture thereof. The plastic of the one inner layer is a mixture of at least one thermoplastic elastomer and at least one thermoplastic polymer. The plastic of the second outer layer is a thermoplastic polymer or a mixture thereof.
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公开(公告)号：US20190058675A1
公开(公告)日：2019-02-21
申请号：US16055864
申请日：2018-08-06
IPC分类号： H04L12/939 , H04L12/861 , H04L12/947 , H04L12/721 , H04L12/801 , H04L12/851 , H04L12/54
摘要： Deadlocks in a heterogeneous packet-based transport system are avoided. When receiving a plurality of packets from a root complex where contents of each packet from the plurality of packets organized in accordance with a first protocol, a sequence number is added to each packet and a packet type is identified. Every packet in the first plurality of packets is encapsulated into at least one packet organized in accordance with a second protocol to form a second plurality of packets organized in accordance with the second protocol. All the packets from the second plurality of packets are sent via a plurality of connections so that each connection from the plurality of connections only transports packets from the second plurality of packets that encapsulate packets from the first plurality that have a same packet type.
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公开(公告)号：US08921080B2
公开(公告)日：2014-12-30
申请号：US13265178
申请日：2010-04-26
申请人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
发明人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The invention relates to an isolated polypeptide having esterase activity comprising an amino acid sequence shown in any one of SEQ ID NO's 2, 4, 6, 8, 10, 12 or 14 or a homologue thereof, comprising an amino acid substitution or deletion of one or more amino acids as shown in said SEQ ID NO's and resulting in a mutant polypeptide having an increased concentration of the fraction of the mutant polypeptide being present as an active and soluble protein in cleared lysate of the mutant polypeptide expressed in E. coli relative to the concentration of the fraction of the polypeptide without the mutation being present as an active and soluble protein in cleared lysate of the polypeptide without the one or more deletion or substitution expressed in E. coli under the same conditions. The invention also relates to nucleic acid encoding the polypeptides according to the invention, and the use of the polypeptides.
摘要翻译： 本发明涉及具有酯酶活性的分离多肽，其包含SEQ ID NO：2,4,6,8,10,12或14中任一项所示的氨基酸序列或其同源物，其包含氨基酸取代或缺失的一个 或更多的氨基酸，如所述SEQ ID NO所示，并且产生突变体多肽的浓度增加，所述突变体多肽作为活性和可溶性蛋白质存在于大肠杆菌中表达的突变多肽的澄清裂解物中，相对于 不存在突变的多肽的级分的浓度作为活性和可溶性蛋白质存在于多肽的澄清裂解物中，而在相同条件下在大肠杆菌中表达的一个或多个缺失或取代。 本发明还涉及编码根据本发明的多肽的核酸和多肽的用途。
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公开(公告)号：US20120100582A1
公开(公告)日：2012-04-26
申请号：US13265178
申请日：2010-04-26
申请人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
发明人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
CPC分类号： C12N9/18
摘要： The invention relates to an isolated polypeptide having esterase activity comprising an amino acid sequence shown in any one of SEQ ID NO's 2, 4, 6, 8, 10, 12 or 14 or a homologue thereof, comprising an amino acid substitution or deletion of one or more amino acids as shown in said SEQ ID NO's and resulting in a mutant polypeptide having an increased concentration of the fraction of the mutant polypeptide being present as an active and soluble protein in cleared lysate of the mutant polypeptide expressed in E. coli relative to the concentration of the fraction of the polypeptide without the mutation being present as an active and soluble protein in cleared lysate of the polypeptide without the one or more deletion or substitution expressed in E. coli under the same conditions. The invention also relates to nucleic acid encoding the polypeptides according to the invention, and the use of the polypeptides.
摘要翻译： 本发明涉及具有酯酶活性的分离多肽，其包含SEQ ID NO：2,4,6,8,10,12或14中任一项所示的氨基酸序列或其同源物，其包含氨基酸取代或缺失的一个 或更多的氨基酸，如所述SEQ ID NO所示，并且产生突变体多肽的浓度增加，所述突变体多肽作为活性和可溶性蛋白质存在于大肠杆菌中表达的突变多肽的澄清裂解物中，相对于 未突变的多肽的级分的浓度作为活性和可溶性蛋白质存在于多肽的澄清裂解物中，而在相同条件下在大肠杆菌中不表达一个或多个缺失或取代。 本发明还涉及编码根据本发明的多肽的核酸和多肽的用途。
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公开(公告)号：US07735595B2
公开(公告)日：2010-06-15
申请号：US11654441
申请日：2007-01-17
申请人： Walter Kogel , Andreas Braun
发明人： Walter Kogel , Andreas Braun
IPC分类号： B62D5/06
CPC分类号： B62D5/065 , B62D5/04 , B62D5/0463 , B62D5/063
摘要： A hydraulic power steering system for a vehicle includes a first, hydraulic actuator for making available steering power or auxiliary steering power for adjusting the steering angle of one or more steered wheels of the vehicle, and with a second electric actuator for making available a steering power or auxiliary steering power for adjusting the steering angle of the steered wheel. For a power steering system, for which the power dissipated is reduced and the operating temperature lowered, the first hydraulic actuator can be taken out of operation while the vehicle is being driven as a function of the trip and/or vehicle parameters.
摘要翻译： 一种用于车辆的液压动力转向系统包括：第一液压致动器，用于提供可用的转向动力或辅助转向动力，用于调节车辆的一个或多个转向轮的转向角;以及第二电致动器，用于提供转向动力 或用于调整转向轮的转向角的辅助转向动力。 对于功率消耗减小并且操作温度降低的动力转向系统，当车辆被驱动时，第一液压致动器可以作为行程和/或车辆参数的函数而被取消运行。
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