公开(公告)号：US08895050B2

公开(公告)日：2014-11-25

申请号：US13336272

申请日：2011-12-23

申请人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

发明人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC分类号： A61K47/00 ,  G01N33/74 ,  C07C275/34 ,  G01N33/543 ,  C07C235/54 ,  C07C275/30 ,  G01N33/566 ,  C07C233/65 ,  A23L1/226 ,  C07D317/68 ,  C07D307/84

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

摘要翻译： 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US08124121B2

公开(公告)日：2012-02-28

申请号：US12257017

申请日：2008-10-23

申请人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

发明人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC分类号： A61K47/00 ,  A61K31/4965

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

摘要翻译： 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US20120201763A1

公开(公告)日：2012-08-09

申请号：US13336272

申请日：2011-12-23

申请人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  Daivd Wallace ,  Amy Xing ,  Klaus Gubernator

发明人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  Daivd Wallace ,  Amy Xing ,  Klaus Gubernator

IPC分类号： A61K8/49 ,  C07D317/68 ,  C07F9/655 ,  C07C235/46 ,  C07D405/12 ,  C07D319/18 ,  C07D321/10 ,  C07D307/85 ,  C07D263/56 ,  C07D241/24 ,  A61K8/55 ,  A61K8/42 ,  A61K47/22 ,  A61K47/24 ,  A61K47/18 ,  A61Q11/00 ,  A23L1/226

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

摘要翻译： 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US20090111834A1

公开(公告)日：2009-04-30

申请号：US12257017

申请日：2008-10-23

申请人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Harry Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

发明人： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Harry Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC分类号： A61K31/4965 ,  A23L1/22 ,  A61K31/44 ,  C07D213/56 ,  C07D241/00 ,  C07D239/02 ,  C07C237/00 ,  A61K31/505

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

摘要翻译： 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US20080148815A1

公开(公告)日：2008-06-26

申请号：US11836736

申请日：2007-08-09

申请人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

发明人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

IPC分类号： G01N1/40

CPC分类号： G01N30/08 ,  G01N2030/085 ,  G01N2030/126

摘要： Apparatus, systems and methods are described for preconcentrators, chemical sensing systems and gas chromatographs. A preconcentrator is described that comprises a hollow enclosure containing a sorbent material. The enclosure may be a capillary tube that can be formed in to a desired shape and that may be heated. Heating may be accomplished by passing an electrical current through the capillary or other hollow enclosure form. The sorbent material can be a liquid, a solid, a porous ceramic material and/or a chemiselective polymer. The sorbent material can be coated to the inner wall of the enclosure. The hollow enclosure may be maintained in an insulated chamber. The preconcentrator acts to concentrate a vapor passed through the preconcentrator to a chemical sensing array that can detect chemicals present in the vapor. A gas passed through the hollow enclosure can provide a chemically concentrated input to a chromatographic column.

摘要翻译： 描述了用于预浓缩器，化学传感系统和气相色谱仪的装置，系统和方法。 描述了一种预浓缩器，其包含含有吸附剂材料的中空外壳。 外壳可以是可以形成为期望形状并且可以被加热的毛细管。 加热可以通过使电流通过毛细管或其它中空的外壳形式来实现。 吸附剂材料可以是液体，固体，多孔陶瓷材料和/或化学选择性聚合物。 吸附剂材料可以涂覆到外壳的内壁。 中空的外壳可以保持在绝缘室中。 预浓缩器用于将通过预浓缩器的蒸汽浓缩到可以检测蒸气中存在的化学物质的化学传感阵列。 通过中空外壳的气体可以向色谱柱提供化学浓度的输入。

公开(公告)号：US20100307224A1

公开(公告)日：2010-12-09

申请号：US12771835

申请日：2010-04-30

申请人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

发明人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

IPC分类号： G01N1/40

CPC分类号： G01N30/08 ,  G01N2030/085 ,  G01N2030/126

摘要： Apparatus, systems and methods are described for preconcentrators, chemical sensing systems and gas chromatographs. A preconcentrator is described that comprises a hollow enclosure containing a sorbent material. The enclosure may be a capillary tube that can be formed in to a desired shape and that may be heated. Heating may be accomplished by passing an electrical current through the capillary or other hollow enclosure form. The sorbent material can be a liquid, a solid, a porous ceramic material and/or a chemiselective polymer. The sorbent material can be coated to the inner wall of the enclosure. The hollow enclosure may be maintained in an insulated chamber. The preconcentrator acts to concentrate a vapor passed through the preconcentrator to a chemical sensing array that can detect chemicals present in the vapor. A gas passed through the hollow enclosure can provide a chemically concentrated input to a chromatographic column.

摘要翻译： 描述了用于预浓缩器，化学传感系统和气相色谱仪的装置，系统和方法。 描述了一种预浓缩器，其包含含有吸附剂材料的中空外壳。 外壳可以是可以形成为期望形状并且可以被加热的毛细管。 加热可以通过使电流通过毛细管或其它中空的外壳形式来实现。 吸附剂材料可以是液体，固体，多孔陶瓷材料和/或化学选择性聚合物。 吸附剂材料可以涂覆到外壳的内壁。 中空的外壳可以保持在绝缘室中。 预浓缩器用于将通过预浓缩器的蒸汽浓缩到可以检测蒸气中存在的化学物质的化学传感阵列。 通过中空外壳的气体可以向色谱柱提供化学浓度的输入。

公开(公告)号：US08117896B2

公开(公告)日：2012-02-21

申请号：US11836736

申请日：2007-08-09

申请人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay Patel ,  Stephen Terrence Hobson

发明人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay Patel ,  Stephen Terrence Hobson

IPC分类号： G01N30/08

CPC分类号： G01N30/08 ,  G01N2030/085 ,  G01N2030/126

摘要： Apparatus, systems and methods are described for preconcentrators, chemical sensing systems and gas chromatographs. A preconcentrator is described that comprises a hollow enclosure containing a sorbent material. The enclosure may be a capillary tube that can be formed in to a desired shape and that may be heated. Heating may be accomplished by passing an electrical current through the capillary or other hollow enclosure form. The sorbent material can be a liquid, a solid, a porous ceramic material and/or a chemiselective polymer. The sorbent material can be coated to the inner wall of the enclosure. The hollow enclosure may be maintained in an insulated chamber. The preconcentrator acts to concentrate a vapor passed through the preconcentrator to a chemical sensing array that can detect chemicals present in the vapor. A gas passed through the hollow enclosure can provide a chemically concentrated input to a chromatographic column.

公开(公告)号：US08333105B2

公开(公告)日：2012-12-18

申请号：US12771835

申请日：2010-04-30

申请人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

发明人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay V. Patel ,  Stephen Terrence Hobson

IPC分类号： G01N30/08

CPC分类号： G01N30/08 ,  G01N2030/085 ,  G01N2030/126

摘要： Apparatus, systems and methods are described for preconcentrators, chemical sensing systems and gas chromatographs. A preconcentrator is described that comprises a hollow enclosure containing a sorbent material. The enclosure may be a capillary tube that can be formed in to a desired shape and that may be heated. Heating may be accomplished by passing an electrical current through the capillary or other hollow enclosure form. The sorbent material can be a liquid, a solid, a porous ceramic material and/or a chemiselective polymer. The sorbent material can be coated to the inner wall of the enclosure. The hollow enclosure may be maintained in an insulated chamber. The preconcentrator acts to concentrate a vapor passed through the preconcentrator to a chemical sensing array that can detect chemicals present in the vapor. A gas passed through the hollow enclosure can provide a chemically concentrated input to a chromatographic column.

摘要翻译： 描述了用于预浓缩器，化学传感系统和气相色谱仪的装置，系统和方法。 描述了一种预浓缩器，其包含含有吸附剂材料的中空外壳。 外壳可以是可以形成为期望形状并且可以被加热的毛细管。 加热可以通过使电流通过毛细管或其它中空的外壳形式来实现。 吸附剂材料可以是液体，固体，多孔陶瓷材料和/或化学选择性聚合物。 吸附剂材料可以涂覆到外壳的内壁。 中空的外壳可以保持在绝缘室中。 预浓缩器用于将通过预浓缩器的蒸汽浓缩到可以检测蒸气中存在的化学物质的化学传感阵列。 通过中空外壳的气体可以向色谱柱提供化学浓度的输入。