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1.发明申请Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor 审中-公开使用替莫唑胺和蛋白激酶抑制剂的药物组合物和方法公开(公告)号：US20070112053A1
公开(公告)日：2007-05-17
申请号：US11522207
申请日：2006-09-15
申请人： Cecil Pickett , Walter Bishop , Yaolin Wang
发明人： Cecil Pickett , Walter Bishop , Yaolin Wang
IPC分类号： A61K31/407
CPC分类号： A61K31/4162 , A61K31/404 , A61K31/407 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： The present invention provides formulations, kits, and methods useful for treating a cell proliferative disorder.
摘要翻译： 本发明提供了可用于治疗细胞增殖性病症的制剂，试剂盒和方法。
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公开(公告)号：US20060233810A1
公开(公告)日：2006-10-19
申请号：US11404967
申请日：2006-04-14
申请人： Yaolin Wang , Ming Liu , Yan Wang , Jonathan Pachter , Walter Bishop
发明人： Yaolin Wang , Ming Liu , Yan Wang , Jonathan Pachter , Walter Bishop
IPC分类号： A61K39/395 , A61K38/12 , A61K31/7072 , A61K31/704 , A61K31/4745 , A61K31/66 , A61K31/525 , A61K31/519
CPC分类号： C07K16/2863 , A61K31/38 , A61K31/4745 , A61K31/519 , A61K31/665 , A61K31/675 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K2039/505 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译： 本发明涉及可用于治疗各种癌症的组合物和方法。 治疗组合及其使用方法也在本申请中被覆盖。
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公开(公告)号：US08859776B2
公开(公告)日：2014-10-14
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号： C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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4.发明申请公开(公告)号：US20120208844A1
公开(公告)日：2012-08-16
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
IPC分类号： A61K31/4545 , A61P35/02 , A61P35/00 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式（1）化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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公开(公告)号：US20180346569A1
公开(公告)日：2018-12-06
申请号：US15777015
申请日：2016-11-17
发明人： Jieyi Wang , Liqun Dong , Yaolin Wang
CPC分类号： C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要： Anti-PD-1 antibodies and uses thereof in treating diseases associated with the PD-1 signaling, such as cancer, infectious diseases such as viral infection or immune related diseases.
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公开(公告)号：US20110262525A1
公开(公告)日：2011-10-27
申请号：US12518409
申请日：2007-12-11
申请人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
发明人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
IPC分类号： A61K39/395 , A61K31/4985 , A61K31/704 , A61K9/127 , A61K31/7072 , A61K31/56 , A61K31/501 , A61K38/46 , A61K39/07 , A61K38/00 , A61K38/18 , A61K38/21 , A61K38/20 , A61P35/00 , A61P35/02 , A61K31/519
CPC分类号： A61K31/00 , A61K31/519 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译： 本发明涉及可用于治疗各种癌症的组合物和方法。 治疗组合及其使用方法也在本申请中被覆盖。
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7.发明申请公开(公告)号：US20110129456A1
公开(公告)日：2011-06-02
申请号：US12991228
申请日：2009-05-04
申请人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
发明人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/675 , A61K39/39533 , A61K2039/545 , C07K2317/56 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to the sequential administration of a cytotoxic agent followed by an IGF1R antagonist (e.g., an antibody) for the treatment of hyperproliferative disorders including cancer.
摘要翻译： 本发明涉及依次施用细胞毒剂，随后是IGF1R拮抗剂（例如抗体），用于治疗包括癌症在内的过度增殖性疾病。
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8.发明申请SOLUBLE, STABLE FORM OF HDM2, CRYSTALLINE FORMS THEREOF AND METHODS OF USE THEREOF 失效可溶性HDM2的稳定形式，其结晶形式及其使用方法公开(公告)号：US20100136620A1
公开(公告)日：2010-06-03
申请号：US12621241
申请日：2009-11-18
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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9.发明授权Polynucleotides encoding soluble, stable forms of human double minute 2 polypeptides 失效编码可溶性，稳定形式的人类双分子2多肽的多核苷酸公开(公告)号：US08034907B2
公开(公告)日：2011-10-11
申请号：US12621241
申请日：2009-11-18
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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公开(公告)号：US20110104256A1
公开(公告)日：2011-05-05
申请号：US12934458
申请日：2009-03-23
申请人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
发明人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
CPC分类号： A61K31/505 , A61K31/436 , A61K31/513 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , A61K2300/00
摘要： The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and 5-fluorouracil.
摘要翻译： 本发明提供了例如与舒尼替尼或甲酰四氢叶酸和5-氟尿嘧啶的组合相结合的抗IGF1R抗体治疗或预防结肠直肠癌的方法。
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