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公开(公告)号：US12070746B2
公开(公告)日：2024-08-27
申请号：US15958142
申请日：2018-04-20
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn , Christopher David Hinojosa , Norman Wen , Geraldine Hamilton
IPC分类号： C12N5/077 , A61K49/00 , A61K51/02 , A61L27/38 , B01L3/00 , C12N5/00 , C12N5/071 , C12N5/074 , C12N5/0775 , G01N33/50 , G01T1/164 , G01T1/29 , C07K14/78 , C12M1/34
CPC分类号： B01L3/5027 , A61K49/0019 , A61K49/005 , A61K51/02 , A61L27/3895 , B01L3/5085 , C12N5/0062 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N5/0662 , C12N5/0663 , C12N5/0668 , C12N5/0696 , C12N5/0697 , G01N33/5038 , G01T1/1644 , G01T1/2985 , A61M2205/3334 , C07K14/78 , C12M41/40
摘要： Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
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公开(公告)号：US11318166B2
公开(公告)日：2022-05-03
申请号：US15315704
申请日：2015-06-04
发明人： Dan Gazit , Edward M. Schwarz , Hyun Bae , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn , Wafa Tawackoli
摘要： Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH+MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.
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公开(公告)号：US20180305668A1
公开(公告)日：2018-10-25
申请号：US15958142
申请日：2018-04-20
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn , Christopher David Hinojosa , Norman Wen , Geraldine Hamilton
IPC分类号： C12N5/077 , C12N5/0775 , C12N5/00
CPC分类号： C12N5/0075 , A61K49/0019 , A61K49/005 , B01L3/5027 , C07K14/78 , C12N5/0062 , C12N5/0654 , C12N5/0663 , G01N33/5038
摘要： Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
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4.发明申请BIOMARKERS FOR THE DIAGNOSIS AND PROGNOSIS OF BACK PAIN AND RELATED CONDITIONS 审中-公开用于诊断和预防背部疼痛和相关条件的生物标志物公开(公告)号：US20160081578A1
公开(公告)日：2016-03-24
申请号：US14785235
申请日：2014-04-18
发明人： Dan Gazit , Debiao Li , Hyun Bae , Gadi Pelled , Zulma Gazit , Qi Liu , Wafa Tawackoli
摘要： The present invention teaches novel methods of diagnosing and prognosing conditions associated with tissue degeneration and/or pain, including intervertebral disc degeneration, discogenic pain, osteoarthritis, rheumatoid arthritis, and articular cartilage injury. Using the inventive noninvasive imaging methods, the diagnosis and prognosis of back pain and related conditions can be quickly and accurately determined by detecting one or more biomarkers disclosed herein.
摘要翻译： 本发明教导了诊断和预测与组织退化和/或疼痛有关的病症的新方法，包括椎间盘退变，椎间盘突出症，骨关节炎，类风湿性关节炎和关节软骨损伤。 使用本发明的非侵入性成像方法，通过检测本文公开的一种或多种生物标志物可以快速和准确地确定背痛和相关病症的诊断和预后。
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公开(公告)号：US12042791B2
公开(公告)日：2024-07-23
申请号：US15958976
申请日：2018-04-20
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn
IPC分类号： C12N5/00 , A61K49/00 , A61K51/02 , A61L27/38 , B01L3/00 , C12N5/071 , C12N5/074 , C12N5/077 , C12N5/0775 , G01N33/50 , G01T1/164 , G01T1/29 , C07K14/78 , C12M1/34
CPC分类号： B01L3/5027 , A61K49/0019 , A61K49/005 , A61K51/02 , A61L27/3895 , B01L3/5085 , C12N5/0062 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N5/0662 , C12N5/0663 , C12N5/0668 , C12N5/0696 , C12N5/0697 , G01N33/5038 , G01T1/1644 , G01T1/2985 , A61M2205/3334 , C07K14/78 , C12M41/40
摘要： Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
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公开(公告)号：US20200093961A1
公开(公告)日：2020-03-26
申请号：US15739555
申请日：2016-06-22
发明人： Zulma Gazit , Dmitriy SHEYN , Gadi PELLED , Dan GAZIT
摘要： Described herein are compositions and methods related to derivation of human notochordal cells differentiated from induced pluripotent stem cells (iPSCs). The inventors have developed a two-step process for generating these iPSC-derived notochordal cells (iNCs), which can provide a renewable source of therapeutic material for use in degenerative disc disease (DDD). As iNCs are capable of reversing DDD and supporting regeneration of invertebral disc (IVD) tissue based on the understanding that NC cells maintain homeostasis and repair of other IVD cell types such as nuclear pulposus (NP).
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公开(公告)号：US20170119823A1
公开(公告)日：2017-05-04
申请号：US15315704
申请日：2015-06-04
发明人： Dan Gazit , Edward M. Schwarz , Hyun Bae , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn , Wafa Tawackoli
CPC分类号： A61K35/28 , A61K9/0019 , A61K38/1875 , A61K38/29 , A61K2300/00
摘要： Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH+MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.
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8.发明申请公开(公告)号：US20230079832A1
公开(公告)日：2023-03-16
申请号：US17986396
申请日：2022-11-14
发明人： Dan Gazit , Debiao Li , Gadi Pelled , Zulma Gazit , Zhengwei Zhou
IPC分类号： A61B5/00 , A61B5/055 , A61B5/145 , G01R33/483 , G01R33/56
摘要： In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.
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公开(公告)号：US20180237741A1
公开(公告)日：2018-08-23
申请号：US15958976
申请日：2018-04-20
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn
CPC分类号： B01L3/5027 , A61K49/0019 , A61K49/005 , A61K51/02 , B01L3/5085 , C07K14/78 , C12N5/0062 , C12N5/0075 , C12N5/0654 , C12N5/0662 , C12N5/0663 , C12N5/0696 , C12N5/0697 , G01N33/5038 , G01T1/1644 , G01T1/2985
摘要： Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
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公开(公告)号：US11554195B2
公开(公告)日：2023-01-17
申请号：US15739555
申请日：2016-06-22
发明人： Zulma Gazit , Dmitriy Sheyn , Gadi Pelled , Dan Gazit
摘要： Described herein are compositions and methods related to derivation of human notochordal cells differentiated from induced pluripotent stem cells (iPSCs). The inventors have developed a two-step process for generating these iPSC-derived notochordal cells (iNCs), which can provide a renewable source of therapeutic material for use in degenerative disc disease (DDD). As iNCs are capable of reversing DDD and supporting regeneration of intervertebral disc (IVD) tissue based on the understanding that NC cells maintain homeostasis and repair of other IVD cell types such as nuclear pulposus (NP).
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