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    OLIGONUCLEOTIDE SPECIFIC UPTAKE OF NANOCONJUGATES
    7.
    发明申请
    OLIGONUCLEOTIDE SPECIFIC UPTAKE OF NANOCONJUGATES 审中-公开
    纳米结构的寡糖特异性获取

    公开(公告)号：US20130178610A1

    公开(公告)日：2013-07-11

    申请号：US13518443

    申请日：2010-12-23

    申请人： Chad A. Mirkin ,  David A. Giljohann

    发明人： Chad A. Mirkin ,  David A. Giljohann

    IPC分类号： C07H21/00 ,  C07H1/00

    CPC分类号： C12N15/113 ,  A61K47/6923 ,  B82Y5/00 ,  C07H1/00 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/351

    摘要： The present invention concerns nanoparticles functionalized with an oligonucleotide and a domain for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a nanoparticle that is taken up by a cell at an efficiency different than a nanoparticle functionalized with the same oligonucleotide but does not contain a domain.

    摘要翻译： 本发明涉及用寡核苷酸和用于各种用途的结构域功能化的纳米颗粒，包括但不限于基因调控。 更具体地，本公开提供了纳米颗粒，其以不同于用相同寡核苷酸官能化但不含结构域的纳米颗粒的效率与细胞一起吸收。

    CONTROLLED AGENT RELEASE AND SEQUESTRATION
    9.
    发明申请
    CONTROLLED AGENT RELEASE AND SEQUESTRATION 审中-公开
    控制代理释放和序列

    公开(公告)号：US20100294952A1

    公开(公告)日：2010-11-25

    申请号：US12687595

    申请日：2010-01-14

    申请人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

    发明人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

    IPC分类号： A61N5/06

    CPC分类号： A61N5/062 ,  A61N2005/0659

    摘要： Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control.

    摘要翻译： 公开了具有纳米棱镜和试剂的纳米结构，例如诊断和/或治疗剂。 在近红外转换照射中具有表面等离子体共振的纳米棱镜，例如从激光选择性地加热以允许与纳米棱镜表面相关的试剂的解离，例如寡核苷酸双链体的脱杂交。 这些纳米结构在照射几小时内显示形态，化学和功能稳定性。 进一步公开的是在定向表面等离子体共振介导的纳米棱镜加热之后从纳米结构中选择性释放试剂的方法。 释放的试剂，如寡核苷酸，不受这个过程的伤害，并且可以在时空控制下重复释放和螯合。