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    PHYSICALLY MODIFIED EXTRACELLULAR MATRIX MATERIALS AND USES THEREOF
    2.
    发明申请
    PHYSICALLY MODIFIED EXTRACELLULAR MATRIX MATERIALS AND USES THEREOF 有权
    物理改性的细胞基质材料及其用途

    公开(公告)号：US20090326577A1

    公开(公告)日：2009-12-31

    申请号：US12489199

    申请日：2009-06-22

    申请人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

    发明人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

    IPC分类号： A61B17/12 ,  A61F2/04

    CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00641 ,  A61B2017/00654

    摘要： Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

    摘要翻译： 描述了扩张的胶原材料及其制备和使用的方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

    Cast bioremodelable graft
    4.
    发明申请
    Cast bioremodelable graft 有权
    铸造生物可重复移植

    公开(公告)号：US20050187604A1

    公开(公告)日：2005-08-25

    申请号：US11054043

    申请日：2005-02-09

    申请人： Scott Eells ,  Michael Hiles ,  Thomas Osborne

    发明人： Scott Eells ,  Michael Hiles ,  Thomas Osborne

    IPC分类号： A61L27/36 ,  A61L27/50 ,  A61L27/58 ,  A61L31/00 ,  A61F2/06

    CPC分类号： A61L27/507 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/58

    摘要： A cast bioremodelable graft (22) comprising a cast tubular construct (33) of a bioremodelable substance (34). The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released from an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23-25) in the graft, which is then loaded on an endoluminal delivery system.

    摘要翻译： 一种包含生物可重塑物质（34）的铸造管状构件（33）的浇注生物可重塑移植物（22）。 将生物可重塑物质浇铸或施加到形式上，然后真空压制以干燥或硬化物质。 可膨胀构件（18）设置在铸造管状结构的内部，下面或周围，以在从内腔输送系统释放时膨胀移植物。 第二层（39）可以施加在第一层（38）上，并且可扩展支架在其间包含支架，而不需要任何单独的附接。 将移植物脱水并优选真空压制以使生物可重塑物质硬化。 去除形式以在移植物中形成一个或多个腔（23-25），然后将其装载在腔内递送系统上。

    VALVE REPAIR SYSTEMS AND METHODS
    7.
    发明申请
    VALVE REPAIR SYSTEMS AND METHODS 审中-公开
    阀门维修系统和方法

    公开(公告)号：US20080097585A1

    公开(公告)日：2008-04-24

    申请号：US11772438

    申请日：2007-07-02

    申请人： Richard Sisken ,  Michael Hiles ,  Neal Fearnot ,  Alan Leewood

    发明人： Richard Sisken ,  Michael Hiles ,  Neal Fearnot ,  Alan Leewood

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2412 ,  A61F2/2475

    摘要： Medical device valve repair systems that include a stabilization member are provided. The stabilization member includes an engaging channel to contact the engaging surface of a valve holding valve leaflets in a position such that a tissue repair device may form a coaptation between the valve leaflets.

    摘要翻译： 提供包括稳定构件的医疗装置阀门维修系统。 稳定构件包括接合通道，以将阀保持瓣膜小叶的接合表面接触在一个位置，使得组织修复装置可以在瓣膜单元之间形成接合。

    Tissue graft prosthesis devices containing juvenile or small diameter submucosa
    8.
    发明申请
    Tissue graft prosthesis devices containing juvenile or small diameter submucosa 审中-公开
    包含少年或小直径粘膜下层的组织移植假体装置

    公开(公告)号：US20060136047A1

    公开(公告)日：2006-06-22

    申请号：US10523892

    申请日：2003-09-04

    申请人： F. Obermiller ,  Michael Hiles ,  Jason Hodde

    发明人： F. Obermiller ,  Michael Hiles ,  Jason Hodde

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61F2/0077 ,  A61F2/07 ,  A61F2002/075

    摘要： Described are preferred tissue graft materials that incorporate juvenile submucosa tissue from a warm-blooded vertebrate. Preferred materials incorporate juvenile small intestinal submucosa tissue from a mammal such as a porcine mammal, and the constructs are preferably in tubular form and utilized the isolated submucosa tissue in its native, intact tubular form. More preferred devices are multi-laminate and include the juvenile submucosa tissue in addition to at least one, and preferably several other layers providing increased strength or other advantageous properties to the construct.

    摘要翻译： 描述的是优选的组织移植材料，其包含来自温血脊椎动物的幼年粘膜下层组织。 优选的材料包括来自哺乳动物如猪哺乳动物的幼年小肠粘膜下层组织，并且构建体优选为管状形式，并以其天然的完整管状形式使用分离的粘膜下层组织。 更优选的装置是多层压的，并且除了至少一个，优选几个其它层之外还包括少年粘膜下层组织，为构建体提供增强的强度或其它有利的性质。