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公开(公告)号：US09788821B2
公开(公告)日：2017-10-17
申请号：US12489199
申请日：2009-06-22
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654
摘要： Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
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公开(公告)号：US20090326577A1
公开(公告)日：2009-12-31
申请号：US12489199
申请日：2009-06-22
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654
摘要： Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译： 描述了扩张的胶原材料及其制备和使用的方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。
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公开(公告)号：US09271817B2
公开(公告)日：2016-03-01
申请号：US12114456
申请日：2008-05-02
申请人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
发明人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
CPC分类号： A61F2/0059 , A61B17/06004 , A61B2017/06052 , A61F2/02 , A61L27/24 , A61M5/32 , A61M25/0662 , A61M2025/018 , Y10S623/915
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
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公开(公告)号：US20110046576A1
公开(公告)日：2011-02-24
申请号：US12939636
申请日：2010-11-04
IPC分类号： A61M5/00
CPC分类号： A61F2/0059
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。
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公开(公告)号：US08470356B2
公开(公告)日：2013-06-25
申请号：US12939636
申请日：2010-11-04
IPC分类号： A61M5/158 , C12N5/00 , A61F2/00 , A61M31/00 , A61M5/178 , A61B17/34 , A61B17/04 , A61B17/06 , C12M1/00
CPC分类号： A61F2/0059
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。
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公开(公告)号：US07850985B2
公开(公告)日：2010-12-14
申请号：US11481422
申请日：2006-07-05
IPC分类号： A61M5/158 , A61F2/00 , C12N5/00 , A61M5/178 , A61M31/00 , C12M1/00 , A61B17/34 , A61B17/04 , A61B17/06
CPC分类号： A61F2/0059
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。
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公开(公告)号：US20080248079A1
公开(公告)日：2008-10-09
申请号：US12114456
申请日：2008-05-02
申请人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
发明人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
CPC分类号： A61F2/0059 , A61B17/06004 , A61B2017/06052 , A61F2/02 , A61L27/24 , A61M5/32 , A61M25/0662 , A61M2025/018 , Y10S623/915
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。
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8.发明授权Composite extracellular matrix materials and medical products formed therefrom 有权复合细胞外基质材料和由此形成的医疗产品公开(公告)号：US08741354B2
公开(公告)日：2014-06-03
申请号：US12488996
申请日：2009-06-22
申请人： Chad E. Johnson , David M. J. Ernst , Amy Overby
发明人： Chad E. Johnson , David M. J. Ernst , Amy Overby
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。
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公开(公告)号：US20110150998A1
公开(公告)日：2011-06-23
申请号：US12644607
申请日：2009-12-22
申请人： Laura-Lee Farrell , Chad E. Johnson
发明人： Laura-Lee Farrell , Chad E. Johnson
CPC分类号： A61K9/0087 , A61K38/39 , A61L27/3633 , A61L31/005 , B29C39/08 , B29C67/20
摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.
摘要翻译： 用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。 可流动的ECM组合物在模具中经受足够的离心力足以根据它们的物理特性的差异分布ECM颗粒。 将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。 干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。
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公开(公告)号：US20090138078A1
公开(公告)日：2009-05-28
申请号：US12273284
申请日：2008-11-18
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译： 提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。 医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料 液体接触可重塑材料。 医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。
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