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31 条记录 (耗时 0.039 秒)

    Selective removal of immune complexes
    2.
    发明授权
    Selective removal of immune complexes 失效
    选择性去除免疫复合物

    公开(公告)号：US5084398A

    公开(公告)日：1992-01-28

    申请号：US601029

    申请日：1990-10-23

    申请人： James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    发明人： James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    IPC分类号： A61M1/36 ,  C07K14/31 ,  C07K17/06

    CPC分类号： A61M1/3679 ,  C07K14/31 ,  C07K17/06

    摘要： Disclosed is a method and a family of materials useful for removing immune complexes from blood preferentially to soluble antibodies. The material comprises analogs of proteins which bind to the Fc region of immunoglobulin. The analogs are produced by truncating or otherwise altering the amino acid sequence of the binding protein to reduce their affinity for Fc. An array of such analogs disposed about the surface of an insoluble matrix has the ability to form multiple points of attachment to the multiple Fc's in a complex so as to bind complex strongly, whereas only weak associations are developed between the Fc region of soluble IgG and inidivdual analogs. The preferred analogs are truncated proteins homologous to a portion of the domains of Protein A or Protein G which bind with Fc. Complex may be removed from whole blood or serum using the material and conventional plasmapheresis techniques.

    摘要翻译： 公开了一种可用于将血液中的免疫复合物优先地去除可溶性抗体的方法和一系列材料。 该材料包含与免疫球蛋白Fc区结合的蛋白质的类似物。 类似物通过截短或以其它方式改变结合蛋白的氨基酸序列来降低它们对Fc的亲和力而产生。 在不溶性基质的表面附近设置的这种类似物的阵列具有在复合物中形成与多个Fc的多个连接点的能力，以便强烈地结合复合物，而仅在可溶性IgG的Fc区和 inidivdual类似物。 优选的类似物是与蛋白A或蛋白G的结合部分与Fc结合的截短的蛋白质。 可以使用材料和常规的血浆置换技术从全血或血清中除去复合物。

    DNA encoding a protein which enables selective removal of immune complexes
    3.
    发明授权
    DNA encoding a protein which enables selective removal of immune complexes 失效
    编码能够选择性去除免疫复合物的蛋白质的DNA

    公开(公告)号：US5243040A

    公开(公告)日：1993-09-07

    申请号：US787669

    申请日：1991-11-04

    申请人： James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    发明人： James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    IPC分类号： A61M1/36 ,  C07K14/31 ,  C07K17/06 ,  C12N15/31

    CPC分类号： A61M1/3679 ,  C07K14/31 ,  C07K17/06

    摘要： Disclosed is a method and a family of materials useful for removing immune complexes from blood preferentially to soluble antibodies. The material comprises analogs of proteins which bind to the Fc region of immunoglobulin. The analogs are produced by truncating or otherwise altering the amino acid sequence of the binding protein to reduce their affinity for Fc. An array of such analogs disposed about the surface of an insoluble matrix has the ability to form multiple points of attachment to the multiple Fc's in a complex so as to bind complex strongly, whereas only weak associations are developed between the Fc region of soluble IgG and individual analogs. The preferred analogs are truncated proteins homologous to a portion of the domains of Protein A or Protein G which bind with Fc. Complex may be removed from whole blood or serum using the material and conventional plasmapheresis techniques.

    摘要翻译： 公开了一种用于从血液中将免疫复合物优先地去除可溶性抗体的方法和一系列材料。 该材料包含与免疫球蛋白Fc区结合的蛋白质的类似物。 类似物通过截短或以其它方式改变结合蛋白的氨基酸序列来降低它们对Fc的亲和力而产生。 在不溶性基质的表面附近设置的这种类似物的阵列具有在复合物中形成与多个Fc的多个连接点的能力，以便强烈地结合复合物，而仅在可溶性IgG的Fc区和 个别类似物。 优选的类似物是与蛋白A或蛋白G的结合部分与Fc结合的截短的蛋白质。 可以使用材料和常规的血浆置换技术从全血或血清中除去复合物。

    Compensation driven network based exchange system and method
    7.
    发明申请
    Compensation driven network based exchange system and method 审中-公开
    补偿驱动网络交换系统和方法

    公开(公告)号：US20050091075A1

    公开(公告)日：2005-04-28

    申请号：US10922379

    申请日：2004-12-27

    申请人： Charles Cohen ,  Neil Forrester

    发明人： Charles Cohen ,  Neil Forrester

    IPC分类号： G06Q30/02 ,  G06F17/60

    CPC分类号： G06Q30/02 ,  G06Q30/0235 ,  G06Q30/0236 ,  G06Q30/0269

    摘要： A method and system using a communication network, such as the Internet, to compensate at least one user in exchange for work undertaken by the at least one user. The communication network is used to perform work, the work being defined by a content provider in a manner which does not target specific user profiles. Compensation units are offered to the user in exchange for the performed work. The user uses a user terminal to accept the offered compensation units. The accepted compensation units are transferred from a content provider account to a user account, the content provider account corresponding to the content provider offering the compensation units and the user account corresponding to user who completed the work. The user can spend earned compensation units on goods and services offered by a redeeming content provider. The compensation units are provided in a closed system. The issuing content provider does not control how, when or where earned compensation units may be spent

    摘要翻译： 一种使用诸如因特网之类的通信网络的方法和系统来补偿至少一个用户以换取由至少一个用户进行的工作。 通信网络用于执行工作，该工作由内容提供商以不针对特定用户简档的方式定义。 向用户提供补偿单位以换取已完成的工作。 用户使用用户终端接受提供的补偿单元。 接受的补偿单元从内容提供者帐户转移到用户帐户，与提供补偿单元的内容提供商对应的内容提供商帐户和与完成工作的用户对应的用户帐户。 用户可以在赎回内容提供商提供的商品和服务上支付获得的赔偿单位。 补偿单元在封闭系统中提供。 发行内容提供商不控制如何，何时或在哪里获得赔偿单位

    REAL-TIME HEAD TRACKING SYSTEM FOR COMPUTER GAMES AND OTHER APPLICATIONS
    9.
    发明申请
    REAL-TIME HEAD TRACKING SYSTEM FOR COMPUTER GAMES AND OTHER APPLICATIONS 审中-公开
    用于计算机游戏和其他应用的实时头跟踪系统

    公开(公告)号：US20070066393A1

    公开(公告)日：2007-03-22

    申请号：US11550138

    申请日：2006-10-17

    申请人： George Paul ,  Glenn Beach ,  Charles Cohen ,  Charles Jacobus

    发明人： George Paul ,  Glenn Beach ,  Charles Cohen ,  Charles Jacobus

    IPC分类号： A63F9/24

    CPC分类号： A63F13/213 ,  A63F13/10 ,  A63F13/42 ,  A63F2300/1012 ,  A63F2300/1087 ,  A63F2300/1093 ,  A63F2300/69 ,  G06F3/012 ,  G06K9/00335 ,  G06K9/4652 ,  G06K9/4661 ,  G06K9/6201 ,  G06T7/20 ,  G06T7/251 ,  G06T7/73 ,  G06T7/90 ,  G06T11/20 ,  G06T2207/10016 ,  G06T2207/30196 ,  G06T2207/30201

    摘要： A real-time computer vision system tracks the head of a computer user to implement real-time control of games or other applications. The imaging hardware includes a color camera, frame grabber, and processor. The software consists of the low-level image grabbing software and a tracking algorithm. The system tracks objects based on the color, motion and/or shape of the object in the image. A color matching function is used to compute three measures of the target's probable location based on the target color, shape and motion. The method then computes the most probable location of the target using a weighting technique. Once the system is running, a graphical user interface displays the live image from the color camera on the computer screen. The operator can then use the mouse to select a target for tracking. The system will then keep track of the moving target in the scene in real-time.

    摘要翻译： 实时计算机视觉系统跟踪计算机用户的头部以实现游戏或其他应用的实时控制。 成像硬件包括彩色摄像机，帧采集器和处理器。 该软件由低级图像抓取软件和跟踪算法组成。 该系统基于图像中对象的颜色，运动和/或形状来跟踪对象。 颜色匹配功能用于基于目标颜色，形状和运动计算目标可能位置的三个度量。 该方法然后使用加权技术计算目标的最可能的位置。 一旦系统运行，图形用户界面将在计算机屏幕上显示来自彩色摄像机的实时图像。 然后，操作员可以使用鼠标选择要跟踪的目标。 然后系统将实时跟踪场景中的移动目标。