公开(公告)号：US20080302664A1

公开(公告)日：2008-12-11

申请号：US12155274

申请日：2008-06-02

申请人： Cheng-Hsien Liu ,  Long Hsu ,  Kuang-Han Chu ,  William Wang ,  Chung-Cheng Chou

发明人： Cheng-Hsien Liu ,  Long Hsu ,  Kuang-Han Chu ,  William Wang ,  Chung-Cheng Chou

IPC分类号： C02F1/469

CPC分类号： G01N27/44713 ,  C02F1/469 ,  C02F2001/46152 ,  C02F2201/4613 ,  G01N2030/285

摘要： An apparatus for driving a fluid includes a substrate, at least one electrode group and a controlling unit. The substrate has at least one plane. The electrode group is disposed on the substrate and includes a first electrode, a second electrode and a third electrode. A projecting position of the second electrode on the plane is disposed between that of the first electrode and that of the third electrode. The controlling unit electrically connected to electrode group is for driving the first to third electrodes. When the controlling unit drives the first to third electrodes to make the first and third electrodes have opposite polarities and to make the second and third electrodes have the same polarity, an electric field produced by the electrode group enables the fluid on the substrate to flow from the first electrode to the third electrode.

摘要翻译： 用于驱动流体的装置包括基板，至少一个电极组和控制单元。 衬底具有至少一个平面。 电极组设置在基板上，并且包括第一电极，第二电极和第三电极。 平面上的第二电极的突出位置设置在第一电极和第三电极的突出位置之间。 电连接到电极组的控制单元用于驱动第一至第三电极。 当控制单元驱动第一至第三电极以使第一和第三电极具有相反的极性并且使得第二和第三电极具有相同的极性时，由电极组产生的电场使得基板上的流体能够从 第一电极到第三电极。

公开(公告)号：US07838819B2

公开(公告)日：2010-11-23

申请号：US12019316

申请日：2008-01-24

申请人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  Wai William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

发明人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  Wai William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

IPC分类号： H01S1/00 ,  H01S3/00 ,  H05H3/02

CPC分类号： G02B21/32 ,  G02B5/1842 ,  G02B21/0088

摘要： An apparatus of generating optical tweezers with momentum is provided for providing optical tweezers with a first momentum on a test piece. The apparatus comprises a laser source, a diffractive optical element (DOE) and a lens. The laser source is for outputting a laser beam. The DOE has a first phase-delay picture, and the laser beam forms a diffraction pattern after passing the first phase-delay picture. The lens is for receiving and focusing the diffraction pattern on the test piece to form the first optical tweezers with the first momentum. The lens has an optical axis intersecting the DOE at an optical intersection point, a geometric center of the phase-delay picture has a displacement vector relative to the optical intersection point and a direction of the first momentum is related to a direction of the displacement vector.

摘要翻译： 提供产生具有动量的光学镊子的装置，用于在测试片上提供具有第一动量的光学镊子。 该装置包括激光源，衍射光学元件（DOE）和透镜。 激光源用于输出激光束。 DOE具有第一相位延迟图像，并且激光束在通过第一相位延迟图像之后形成衍射图案。 透镜用于接收和聚焦在测试片上的衍射图案以形成具有第一动量的第一光学镊子。 透镜在光学交点处具有与DOE相交的光轴，相位延迟图像的几何中心具有相对于光学交叉点的位移矢量，并且第一动量的方向与位移矢量的方向相关 。

公开(公告)号：US20090052038A1

公开(公告)日：2009-02-26

申请号：US12222250

申请日：2008-08-06

申请人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

发明人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

IPC分类号： G02B27/42

CPC分类号： G02B21/32

摘要： An apparatus and a method for changing optical tweezers are provided. The apparatus includes a diffractive optical element (DOE), a mask unit and an objective lens. The DOE includes a plurality of phase delay patterns. The mask unit includes a plurality of mask patterns that correspond to the phase delay patterns, respectively, wherein at least a portion of the mask patterns are complementary. A laser beam passing through each phase diffractive pattern correspondingly passes through each mask pattern to generate a compound diffractive pattern. The objective lens receives the compound diffractive pattern and focuses it on an examining object to form an optical tweezers.

摘要翻译： 提供了一种用于改变光学镊子的设备和方法。 该装置包括衍射光学元件（DOE），掩模单元和物镜。 DOE包括多个相位延迟模式。 掩模单元包括分别对应于相位延迟图案的多个掩模图案，其中至少一部分掩模图案是互补的。 通过每个相位衍射图案的激光束相应地通过每个掩模图案以产生复合衍射图案。 物镜接收复合衍射图案并将其聚焦在检查对象上以形成光学镊子。

公开(公告)号：US20120043209A1

公开(公告)日：2012-02-23

申请号：US13212596

申请日：2011-08-18

申请人： Cheng-Hsien Liu ,  William Wang ,  Long Hsu ,  Yuh-Shyong Yang ,  Hwan-You Chang ,  Shih-Mo Yang ,  Chung-Cheng Chou

发明人： Cheng-Hsien Liu ,  William Wang ,  Long Hsu ,  Yuh-Shyong Yang ,  Hwan-You Chang ,  Shih-Mo Yang ,  Chung-Cheng Chou

IPC分类号： G01N27/447 ,  B01D21/00 ,  G01N27/453

CPC分类号： B01L3/50273 ,  B01D21/0009 ,  B01L3/502761 ,  B01L2200/14 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0418 ,  B01L2400/082 ,  G01N35/1095

摘要： A microfluidic control apparatus and operating method thereof. The microfluidic control apparatus includes a photoconductive material layer and a flow passage. When a light with a specific optical pattern is emitted toward the photoconductive material layer, at least three virtual electrodes are formed on the photoconductive material layer according to the specific optical pattern. The at least three virtual electrodes include a first virtual electrode, a second virtual electrode and a third virtual electrode disposed beside the first virtual electrode. There is a specific proportion among a distance between first virtual electrode and third virtual electrode, a width of first virtual electrode, a distance between first virtual electrode and second virtual electrode, and a width of second virtual electrode. When the specific optical pattern changes, the at least three virtual electrodes also change to generate an electro-osmotic force to control the moving state of a microfluid in a flow passage.

摘要翻译： 一种微流控制装置及其操作方法。 微流控制装置包括光导材料层和流路。 当向光导材料层发射具有特定光学图案的光时，根据特定光学图案在光导材料层上形成至少三个虚拟电极。 所述至少三个虚拟电极包括设置在第一虚拟电极旁边的第一虚拟电极，第二虚拟电极和第三虚拟电极。 在第一虚拟电极和第三虚拟电极之间的距离，第一虚拟电极的宽度，第一虚拟电极和第二虚拟电极之间的距离以及第二虚拟电极的宽度之间存在特定比例。 当特定光学图案改变时，至少三个虚拟电极也改变以产生电渗压力以控制流路中微流体的移动状态。

公开(公告)号：US20090097119A1

公开(公告)日：2009-04-16

申请号：US12143943

申请日：2008-06-23

申请人： Chen Peng ,  William Wang ,  Chung-Cheng Chou ,  Fung-Hsu Wu ,  Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng

发明人： Chen Peng ,  William Wang ,  Chung-Cheng Chou ,  Fung-Hsu Wu ,  Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng

IPC分类号： G02B27/42

CPC分类号： G02B21/32 ,  G02B27/42 ,  G02B27/4233

摘要： A diffraction micro flow structure and optical tweezers using the same are provided. The diffraction micro flow structure comprises a substrate and a diffraction part. The substrate comprises at least a flow path. The diffraction part is disposed on the substrate. The diffraction part comprises a diffraction optical element. After light passes through the diffraction optical element, the light is focused in the flow path and forms an optical field.

摘要翻译： 提供衍射微流结构和使用其的光学镊子。 衍射微流结构包括基底和衍射部分。 衬底包括至少一个流动路径。 衍射部分设置在基板上。 衍射部分包括衍射光学元件。 光通过衍射光学元件后，光在流路中聚焦并形成光场。

公开(公告)号：US20080186801A1

公开(公告)日：2008-08-07

申请号：US12014813

申请日：2008-01-16

申请人： Cheng-Hsien Liu ,  Long Hsu ,  Chih-Ming Cheng ,  Sheng-Hung Chiu ,  Wai William Wang ,  Chung-Cheng Chou

发明人： Cheng-Hsien Liu ,  Long Hsu ,  Chih-Ming Cheng ,  Sheng-Hung Chiu ,  Wai William Wang ,  Chung-Cheng Chou

IPC分类号： B01F13/00 ,  B01F3/08 ,  B01F15/02 ,  F04B17/00

CPC分类号： B01F13/0059 ,  B01F5/10 ,  B01F11/0071 ,  F04B17/00 ,  F04B19/006 ,  F04B19/24

摘要： A bubble micro-pump includes a first component, a second component and a bubble-generating unit. The first component includes a flow path having a first area and a second area. The second component above the first component has a first roughness surface and a second roughness surface. The first roughness surface opposite the first area has a first roughness factor, and the second roughness surface opposite the second area has a second roughness factor smaller than the first roughness factor. The bubble-generating unit on the first component generates bubble in the first area and the second area when a fluid fills the vacancy between the first component and the second component. Due to the difference in roughness factor, the backfilling velocity of the fluid in the first area is faster than that in the second area when the bubble starts to vanish, such that the fluid is driven to flow.

摘要翻译： 气泡微型泵包括第一部件，第二部件和气泡发生单元。 第一部件包括具有第一区域和第二区域的流动路径。 第一部件上方的第二部件具有第一粗糙度表面和第二粗糙度表面。 与第一区域相对的第一粗糙表面具有第一粗糙度因子，并且与第二区域相对的第二粗糙度表面具有小于第一粗糙度因子的第二粗糙度因子。 当第一部件和第二部件之间的空隙充满时，第一部件上的气泡发生单元在第一区域和第二区域中产生气泡。 由于粗糙度因子的差异，当气泡开始消失时，第一区域中的流体的回填速度比第二区域的回填速度快，使得流体被驱动流动。

公开(公告)号：US08258461B2

公开(公告)日：2012-09-04

申请号：US12219871

申请日：2008-07-30

申请人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  William Wang ,  Chung-Cheng Chou ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

发明人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  William Wang ,  Chung-Cheng Chou ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

IPC分类号： B01D21/01

CPC分类号： G02B21/32 ,  Y10T436/25375

摘要： An apparatus of generating an optical tweezers with momentum and method thereof and an optical tweezers photo-image for guiding particles are provided. The apparatus generates at least one optical tweezers on an examined object that carries at least one particle. The apparatus includes a laser source, a diffractive optical element and a convergent lens. The laser beam from the laser source passes through the diffractive optical element to produce a diffractive pattern. The laser beam is then received by the convergent lens and then to be focused on a plane of the examined object. The optic axis of the convergent lens is substantially not perpendicular to the plane of the examined object, so that the laser beam is projected onto the plane of the examined object in a skewed manner for providing a lateral momentum to move the particle.

摘要翻译： 提供了一种用于产生具有动量及其方法的光学镊子的装置和用于引导颗粒的光学镊子照片。 该装置在携带至少一个颗粒的被检查物体上产生至少一个光学镊子。 该装置包括激光源，衍射光学元件和会聚透镜。 来自激光源的激光束通过衍射光学元件以产生衍射图案。 然后激光束被会聚透镜接收，然后被聚焦在被检查物体的平面上。 会聚透镜的光轴基本上不垂直于被检查物体的平面，使得激光束以倾斜的方式投影到被检查物体的平面上，以提供横向动量来移动颗粒。

公开(公告)号：US07804058B2

公开(公告)日：2010-09-28

申请号：US12222249

申请日：2008-08-06

申请人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Ai-Tang Chang ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

发明人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Ai-Tang Chang ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

IPC分类号： H01S1/00 ,  H01S3/00 ,  H05H3/02

CPC分类号： G02B21/32

摘要： An optical tweezers controlling device including a light source, an objective lens and a focus adjusting unit is provided. The focus adjusting unit disposed between the light source and the objective lens includes a mirror set and a zoom lens set. The mirror set has at least a mirror. The mirror is rotatable such that after a light of the light source is projected to the mirror, the reflective direction of the light reflected from the mirror is changeable. The zoom lens set has at least a zoom lens disposed in accordance with the mirror. By rotating the mirror or changing the focal length of the zoom lens, the focusing location of the light changes on the focal plane of the objective lens or in the front or the rear of the focal plane.

摘要翻译： 提供一种包括光源，物镜和焦点调节单元的光学镊子控制装置。 设置在光源和物镜之间的聚焦调节单元包括镜组和变焦透镜组。 镜子至少有一个镜子。 反射镜可旋转，使得在光源的光被投射到反射镜之后，从反射镜反射的光的反射方向是可变的。 变焦透镜组具有至少根据镜子设置的变焦透镜。 通过旋转镜子或改变变焦镜头的焦距，光的聚焦位置在物镜的焦平面或焦平面的前面或后面改变。

公开(公告)号：US07786432B2

公开(公告)日：2010-08-31

申请号：US12222250

申请日：2008-08-06

申请人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

发明人： Long Hsu ,  Cheng-Hsien Liu ,  Sheng-Yang Tseng ,  Chung-Cheng Chou ,  William Wang ,  Fung-Hsu Wu ,  Chen Peng ,  Ta-Yuan Lee

IPC分类号： H01S1/00 ,  H01S3/00 ,  H05H3/02

CPC分类号： G02B21/32

摘要： An apparatus and a method for changing optical tweezers are provided. The apparatus includes a diffractive optical element (DOE), a mask unit and an objective lens. The DOE includes a plurality of phase delay patterns. The mask unit includes a plurality of mask patterns that correspond to the phase delay patterns, respectively, wherein at least a portion of the mask patterns are complementary. A laser beam passing through each phase diffractive pattern correspondingly passes through each mask pattern to generate a compound diffractive pattern. The objective lens receives the compound diffractive pattern and focuses it on an examining object to form an optical tweezers.

摘要翻译： 提供了一种用于改变光学镊子的设备和方法。 该装置包括衍射光学元件（DOE），掩模单元和物镜。 DOE包括多个相位延迟模式。 掩模单元包括分别对应于相位延迟图案的多个掩模图案，其中至少一部分掩模图案是互补的。 通过每个相位衍射图案的激光束相应地通过每个掩模图案以产生复合衍射图案。 物镜接收复合衍射图案并将其聚焦在检查对象上以形成光学镊子。

公开(公告)号：US20090272180A1

公开(公告)日：2009-11-05

申请号：US12272872

申请日：2008-11-18

申请人： Yuh-Shyong Yang ,  Ming-Yu Lin ,  Kun-Hsi Tsai ,  William Wang ,  Long Hsu ,  Cheng-Hsien Liu ,  Chung-Cheng Chou

发明人： Yuh-Shyong Yang ,  Ming-Yu Lin ,  Kun-Hsi Tsai ,  William Wang ,  Long Hsu ,  Cheng-Hsien Liu ,  Chung-Cheng Chou

IPC分类号： G01N33/49

CPC分类号： G01N21/31 ,  B01L3/502761 ,  B01L3/502792 ,  B01L9/527 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0424 ,  B01L2400/0427 ,  B01L2400/0454 ,  B03C5/005 ,  B03C5/026 ,  G01N21/05 ,  G01N33/491 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/062

摘要： A continuous testing device for testing the concentration of a target object in a fluid is provided. The continuous testing device includes a first chip, a signal source and a second chip. The first chip includes a separating unit and a reacting unit. The separating unit separates the target object from a non-target object in the fluid. The reacting unit enables the fluid having separated out the non-target object to react with a reagent. The signal source provides a signal passing through the fluid having reacted with the reagent. The second chip disposed at one side of the first chip includes a signal transducing element and a processing unit. The signal transducing element receives the signal passing through the fluid and outputs an electronic signal corresponding to the input signal. The processing unit acquires the concentration of the target object according to the electronic signal.

摘要翻译： 提供了用于测试流体中目标物体的浓度的连续测试装置。 连续测试装置包括第一芯片，信号源和第二芯片。 第一芯片包括分离单元和反应单元。 分离单元将目标物体与流体中的非目标物体分离。 反应单元使得分离出非目标物体的流体能够与试剂反应。 信号源提供通过与试剂反应的流体的信号。 布置在第一芯片的一侧的第二芯片包括信号转换元件和处理单元。 信号转换元件接收通过流体的信号并输出​​与输入信号相对应的电子信号。 处理单元根据电子信号获取目标物体的浓度。