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14 条记录 (耗时 0.024 秒)

    MICROVESICLES CARRYING SMALL INTERFERING RNAS PREPARATION METHODS AND USES THEREOF
    1.
    发明申请
    MICROVESICLES CARRYING SMALL INTERFERING RNAS PREPARATION METHODS AND USES THEREOF 有权
    携带小干扰RNAS的微胶囊制备方法及其用途

    公开(公告)号：US20140302119A2

    公开(公告)日：2014-10-09

    申请号：US13700067

    申请日：2010-05-26

    申请人： Chenyu Zhang ,  Ke Zeng ,  Danqing Liu ,  Yujing Zhang ,  Hongwei Gu

    发明人： Chenyu Zhang ,  Ke Zeng ,  Danqing Liu ,  Yujing Zhang ,  Hongwei Gu

    IPC分类号： C12N15/113 ,  C12Q1/68 ,  A61K9/127

    CPC分类号： C12N15/113 ,  A61K9/127 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12Q1/68

    摘要： Microvesicles containing interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing interfering RNAs are also provided. Microvesicles containing interfering RNAs, pharmaceutical compositions and kits comprising such microvesicles can be used to study the effects of interfering RNAs on receptor cells. As microvesicles containing interfering RNAs can stably, high efficiently and specifically deliver interfering RNAs, microvesicles containing interfering RNAs can be used to treat related diseases.

    摘要翻译： 提供含有干扰RNA的微泡，其制备方法和用途。 还提供了包含含有干扰RNA的微泡的药物组合物和试剂盒。 含有干扰RNA的微泡，包含这种微泡的药物组合物和试剂盒可用于研究干扰RNA对受体细胞的影响。 由于含有干扰RNA的微泡可以稳定，高效且特异性地递送干扰RNA，所以含有干扰RNA的微泡可用于治疗相关疾病。

    MICROVESICLES CARRYING SMALL INTERFERING RNAS, PREPARATION METHODS AND USES THEREOF
    3.
    发明申请
    MICROVESICLES CARRYING SMALL INTERFERING RNAS, PREPARATION METHODS AND USES THEREOF 有权
    携带小干扰RNAs的微胶囊，其制备方法及其用途

    公开(公告)号：US20130209544A1

    公开(公告)日：2013-08-15

    申请号：US13700067

    申请日：2010-05-26

    申请人： Chenyu Zhang ,  Ke Zeng ,  Danqing Liu ,  Yujing Zhang ,  Hongwei Gu

    发明人： Chenyu Zhang ,  Ke Zeng ,  Danqing Liu ,  Yujing Zhang ,  Hongwei Gu

    IPC分类号： C12N15/113 ,  C12Q1/68 ,  A61K9/127

    CPC分类号： C12N15/113 ,  A61K9/127 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12Q1/68

    摘要： Microvesicles containing interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing interfering RNAs are also provided. Microvesicles containing interfering RNAs, pharmaceutical compositions and kits comprising such microvesicles can be used to study the effects of interfering RNAs on receptor cells. As microvesicles containing interfering RNAs can stably, high efficiently and specifically deliver interfering RNAs, microvesicles containing interfering RNAs can be used to treat related diseases.

    摘要翻译： 提供含有干扰RNA的微泡，其制备方法和用途。 还提供了包含含有干扰RNA的微泡的药物组合物和试剂盒。 含有干扰RNA的微泡，包含这种微泡的药物组合物和试剂盒可用于研究干扰RNA对受体细胞的影响。 由于含有干扰RNA的微泡可以稳定，高效且特异性地递送干扰RNA，所以含有干扰RNA的微泡可用于治疗相关疾病。

    Serum or plasma microRNA as biomarkers for non-small cell lung cancer
    7.
    发明授权
    Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
    血清或血浆microRNA作为非小细胞肺癌的生物标志物

    公开(公告)号：US09388470B2

    公开(公告)日：2016-07-12

    申请号：US12996967

    申请日：2009-12-14

    申请人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    发明人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

    摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.

    摘要翻译： 本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。 非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。 本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。 本发明还提供了一种用于检测所述肺癌标志物的方法。 本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。 该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

    SERUM/PLASMA MICRONAS AND USES THEREOF
    9.
    发明申请
    SERUM/PLASMA MICRONAS AND USES THEREOF 审中-公开

    公开(公告)号：US20100173288A1

    公开(公告)日：2010-07-08

    申请号：US12302196

    申请日：2007-12-06

    申请人： Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    发明人： Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2525/207

    摘要： This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute/chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute/chronic infectious diseases caused by various pathogenic microorganisms; other acute/chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

    Method for Modulating MicroRNA Content in Living Beings and the Use Thereof
    10.
    发明申请
    Method for Modulating MicroRNA Content in Living Beings and the Use Thereof 有权
    调节生物中微RNA含量的方法及其用途

    公开(公告)号：US20130078225A1

    公开(公告)日：2013-03-28

    申请号：US13641074

    申请日：2010-04-13

    申请人： Ke Zeng ,  Chenyu Zhang ,  Junfeng Zhang ,  Haijin Li

    发明人： Ke Zeng ,  Chenyu Zhang ,  Junfeng Zhang ,  Haijin Li

    IPC分类号： A61K35/14 ,  A61K35/28 ,  A61K35/36

    CPC分类号： A61K35/14 ,  A61K35/28 ,  A61K35/36 ,  C12N15/111 ,  C12N15/88 ,  C12N2310/141 ,  C12N2320/32

    摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.

    摘要翻译： 本发明涉及一种用于调节生物中miRNA含量的方法及其用途，其中miRNA通过微粒/ MV /外来体主动和选择性递送至循环系统和靶细胞/组织以执行各种功能。 本发明提供介导细胞间通讯的分子的新型组合：通过细胞MV分泌细胞的miRNA。 同时，本发明还提供了一种制备截留某些miRNA的细胞MV的方法，并且根据miRNA携带细胞MV对细胞和组织中基因表达的调节和修饰，提供了调节生物中miRNA含量的新方法 生物，对所有细胞类型有效和可应用。