公开(公告)号：US20070076217A1

公开(公告)日：2007-04-05

申请号：US11243665

申请日：2005-10-05

申请人： Chris Baker ,  Matthew Everett ,  Yan Zhou ,  Keith O'Hara

发明人： Chris Baker ,  Matthew Everett ,  Yan Zhou ,  Keith O'Hara

IPC分类号： G01B11/02

CPC分类号： A61B3/102 ,  A61B3/1005 ,  A61B5/0066

摘要： An accurate measure of eye length can be obtained using concurrent OCT measurements. A position OCT device can be used to continually monitor the position of the front surface of the cornea, while a distance OCT device can determine the apparent distance between the front surface of the cornea and the front surface of the retina. Since the eye is likely to move during the period of time between measurements of the cornea and retina, the monitored position of the cornea can be used to correct the apparent length measurement by the amount of eye movement over that period of time, in order to obtain an accurate measure of eye length. In some embodiments a single OCT device can serve the dual role of monitoring eye position while making eye length measurements

摘要翻译： 使用并行OCT测量可以获得眼睛长度的精确测量。 位置OCT装置可以用于连续监视角膜前表面的位置，而距离OCT装置可以确定角膜前表面和视网膜的前表面之间的表观距离。 由于眼睛可能在角膜和视网膜的测量之间的时间段期间移动，所以可以使用角膜的监视位置来校正视力长度测量量在该时间段内的眼睛移动量，以便 获得眼睛长度的准确度量。 在一些实施例中，单个OCT设备可以起到监视眼睛位置的双重作用，同时进行眼睛长度测量

公开(公告)号：US20070030483A1

公开(公告)日：2007-02-08

申请号：US11196043

申请日：2005-08-03

申请人： Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

发明人： Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

IPC分类号： G01J3/28

CPC分类号： G01N21/4795 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/0286 ,  G01J3/18 ,  G01J3/22 ,  G02B5/1814 ,  G02B27/4244

摘要： A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.

摘要翻译： 公开了一种紧凑的圆锥衍射Littrow光谱仪。 对锥形衍射光谱分量光束的失真进行补偿，结果衍射的光束束仍可被聚焦成基本上直线以照射到检测器阵列上。 还公开了包含Littrow光谱仪或具有一个或多个共享聚焦元件的光谱仪的光谱相干光学相干断层扫描（SD-OCT）系统和包含基本上偏振无关的光谱仪的SD-OCT系统。

公开(公告)号：US20060164653A1

公开(公告)日：2006-07-27

申请号：US11331567

申请日：2006-01-13

申请人： Matthew Everett ,  Keith O'Hara

发明人： Matthew Everett ,  Keith O'Hara

IPC分类号： G01B9/02

CPC分类号： A61B3/102 ,  A61B3/0025 ,  A61B3/113 ,  A61B3/1233 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02048 ,  G01B9/02077 ,  G01B9/02087 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787

摘要： An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. Significant sample motion may occur during acquisition of the second set. A-scans from the first set are matched with A-scans from the second set, based on similarity between the longitudinal optical scattering profiles they contain. Such matched pairs of A-scans are likely to correspond to the same region in the sample. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair, in conjunction with any shift in the longitudinal scattering profiles between the pair of A-scans, reveals the displacement of the sample between acquisition of the first and second A-scans in the pair. Estimates of the sample displacement are used to correct the transverse and longitudinal coordinates of the A-scans in the second set, to form a motion-corrected OCT data set.

公开(公告)号：US20060228011A1

公开(公告)日：2006-10-12

申请号：US11389351

申请日：2006-03-24

申请人： Matthew Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott Meyer ,  Keith O'Hara ,  Rick Williams

发明人： Matthew Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott Meyer ,  Keith O'Hara ,  Rick Williams

IPC分类号： G09G5/00 ,  G06K9/00

CPC分类号： A61B3/102 ,  A61B3/113

摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

公开(公告)号：US20070002327A1

公开(公告)日：2007-01-04

申请号：US11174158

申请日：2005-07-01

申请人： Yan Zhou ,  Matthew Everett

发明人： Yan Zhou ,  Matthew Everett

IPC分类号： G01J3/45 ,  G01B11/02 ,  G01B9/02

CPC分类号： G01J3/10 ,  A61B3/1005 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/45 ,  G01J3/0259 ,  G01J3/4532 ,  G01J2003/1239 ,  G01N21/4795

摘要： The present invention is an alternative Fourier domain optical coherence system (FD-OCT) and its associated method. The system comprises a swept multi-wavelength laser, an optical interferometer and a multi-channel receiver. By employing a multi-wavelength laser, the sweeping range for each lasing wavelength is substantially reduced as compared to a pure swept single wavelength laser that needs to cover the same overall spectral range. The overall spectral interferogram is divided over the individual channels of the multi-channel receiver and can be re-constructed through processing of the data from each channel detector. In addition to a substantial increase in the speed of each axial scan, the cost of invented FD-OCT system can also be substantially less than that of a pure swept source OCT or a pure spectral domain OCT system.

摘要翻译： 本发明是替代的傅里叶域光学相干系统（FD-OCT）及其相关方法。 该系统包括扫频多波长激光器，光学干涉仪和多通道接收器。 通过采用多波长激光器，与需要覆盖相同总光谱范围的纯扫频单波长激光器相比，每个激光波长的扫描范围显着降低。 整个光谱干涉图在多通道接收机的各个通道上分配，并且可以通过处理来自每个通道检测器的数据来重新构建。 除了每个轴向扫描的速度的显着增加之外，发明的FD-OCT系统的成本也可以显着小于纯扫频源OCT或纯谱域OCT系统的成本。

公开(公告)号：US20060072424A1

公开(公告)日：2006-04-06

申请号：US10933795

申请日：2004-09-03

申请人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

发明人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

IPC分类号： G11B7/135

CPC分类号： A61B3/102 ,  A61B3/1005 ,  G01B9/02012 ,  G01B9/02044 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/35

摘要： A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.

摘要翻译： 公开了一种低成本图案旋转盘，用于实现光束的相对快速的离散光学相移。 本发明在频域光学相干断层摄影系统中特别有用。 盘包含不同高度和/或折射率分布的阶梯图案，使得当其旋转时，通过或被盘反射的光束将经历不同的离散光学相位延迟。 磁盘可以作为移相器来操作，或者可以与强度调制斩波盘同步操作，也可以与光源进行直接强度调制。 磁盘还可以包含强度调制模式，使得可以同时实现相移和强度调制。 还公开了用于制造盘的各种可能的方法。

公开(公告)号：US20050213103A1

公开(公告)日：2005-09-29

申请号：US10811748

申请日：2004-03-29

申请人： Matthew Everett ,  Yan Zhou

发明人： Matthew Everett ,  Yan Zhou

IPC分类号： A61B5/00 ,  G01B9/02 ,  G01M11/00 ,  G01N21/47

CPC分类号： G01M11/3181 ,  A61B5/0066 ,  A61B5/0084 ,  G01B9/0201 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/40 ,  G01B2290/70 ,  G01N21/4795

摘要： The present invention discloses simple and yet highly efficient configurations of optical coherence domain reflectometry systems. The combined use of a polarizing beam splitter with one or two polarization manipulator(s) that rotate the returned light wave polarization to an orthogonal direction, enables one to achieve high optical power delivery efficiency as well as fixed or predetermined output polarization state of the interfering light waves reaching a detector or detector array, which is especially beneficial for spectral domain optical coherence tomography. In addition, the system can be made insensitive to polarization fading resulting from the birefringence change in the sample and reference arms. Dispersion matching can also be easily achieved between the sample and the reference arm for high resolution longitudinal scanning.

摘要翻译： 本发明公开了光学相干畴反射系统的简单且高效的配置。 将偏振分束器与一个或两个偏振操纵器组合使用，其将返回的光波偏振旋转到正交方向，使得能够实现高的光功率传递效率以及干涉的固定或预定的输出偏振状态 光波到达检测器或检测器阵列，这对于光谱域光学相干断层扫描是特别有益的。 此外，该系统可以对由样品和参考臂中的双折射变化导致的偏振衰落不敏感。 也可以在样品和参考臂之间轻松实现色散匹配，实现高分辨率纵向扫描。

公开(公告)号：US20060109477A1

公开(公告)日：2006-05-25

申请号：US11264871

申请日：2005-11-02

申请人： Yan Zhou ,  Matthew Everett ,  Martin Hacker

发明人： Yan Zhou ,  Matthew Everett ,  Martin Hacker

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B2290/40

摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In a first set of embodiments, a 3×3 coupler is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. In an alternate set of embodiments, a pair of cascaded 2×2 couplers provides a similar function. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.

摘要翻译： 公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。 在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。 在第一组实施例中，使用3x3耦合器沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。 在另一组实施例中，一对级联的2x2耦合器提供类似的功能。 干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

公开(公告)号：US20070103693A1

公开(公告)日：2007-05-10

申请号：US11223549

申请日：2005-09-09

申请人： Matthew Everett ,  Scott Meyer ,  Paul Stetson ,  Yan Zhou

发明人： Matthew Everett ,  Scott Meyer ,  Paul Stetson ,  Yan Zhou

IPC分类号： G01B9/02 ,  G06K9/00 ,  A61B5/05 ,  A61B5/103

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

公开(公告)号：US20060158655A1

公开(公告)日：2006-07-20

申请号：US11298105

申请日：2005-12-09

申请人： Matthew Everett ,  Yan Zhou

发明人： Matthew Everett ,  Yan Zhou

IPC分类号： G01B9/02

CPC分类号： A61B5/0066 ,  A61B3/102 ,  A61B3/1025 ,  A61B5/0059

摘要： This invention provides a better apparatus and method for the generation of Optical Coherence Tomography (OCT) and Confocal Scanning Laser Ophthalmoscope (CSLO) images, using a dual-waveguiding module. A dual-waveguiding structure consists of a single-mode and a multi-mode waveguide each with optimum size and numerical aperture for highly efficient collection of the OCT and CSLO optical signals. Separation of the two signals is achieved by channeling most of the multi-mode guided optical power to a CSLO detector. The non-tapped single-mode guided optical wave is further sent to a pure single-mode fiber of a standard OCT system for OCT image generation. The present invention achieves highly efficient optical power usage and hence high signal to noise ratio, together with inherent pixel-to-pixel registration of the OCT and CSLO images, and a cost reduction of the OCT/CSLO combo system.

摘要翻译： 本发明提供了使用双波导模块生成光学相干断层扫描（OCT）和共焦扫描激光眼镜（CSLO）图像的更好的装置和方法。 双波导结构由单模和多模波导组成，每个具有最佳尺寸和数值孔径，用于高效收集OCT和CSLO光信号。 通过将大多数多模式引导光功率传送到CSLO检测器来实现两个信号的分离。 非点击式单模导波光被进一步发送到用于OCT图像生成的标准OCT系统的纯单模光纤。 本发明实现了高效的光功率使用，因此实现了高信噪比，以及OCT和CSLO图像的固有像素到像素配准，以及OCT / CSLO组合系统的成本降低。